{"id":"https://openalex.org/W2184237298","doi":null,"title":"The role and mechanisms of angiotensin II in regulating the natriuretic peptide gene expression in response to cardiac overload","display_name":"The role and mechanisms of angiotensin II in regulating the natriuretic peptide gene expression in response to cardiac overload","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2184237298","mag":"2184237298"},"language":"en","primary_location":{"id":"mag:2184237298","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514266994.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028686966","display_name":"Maria Suo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Suo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028686966"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9330000281333923},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiac-overload","display_name":"cardiac overload","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.878000020980835},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7409999966621399},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8709999918937683},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.953000009059906},{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hemodynamic-stress","display_name":"hemodynamic stress","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5720000267028809},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.75}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8618646860122681},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.818878710269928},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7694519758224487},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.7370550036430359},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7301648855209351},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.5282095074653625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4808793365955353},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.4678194224834442},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.4632815718650818},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.3856023848056793},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3737804889678955},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.36702829599380493},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.0688454806804657}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184237298","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514266994.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":478,"referenced_works":["https://openalex.org/W13357976","https://openalex.org/W19721907","https://openalex.org/W85641358","https://openalex.org/W105279024","https://openalex.org/W126627744","https://openalex.org/W896281434","https://openalex.org/W1428544408","https://openalex.org/W1479831323","https://openalex.org/W1482605042","https://openalex.org/W1489316903","https://openalex.org/W1497553226","https://openalex.org/W1500832403","https://openalex.org/W1501522779","https://openalex.org/W1501545448","https://openalex.org/W1516457342","https://openalex.org/W1521804991","https://openalex.org/W1526362532","https://openalex.org/W1527988096","https://openalex.org/W1534224609","https://openalex.org/W1537399302","https://openalex.org/W1546454746","https://openalex.org/W1574889281","https://openalex.org/W1577509897","https://openalex.org/W1591510379","https://openalex.org/W1606727311","https://openalex.org/W1825266751","https://openalex.org/W1830702703","https://openalex.org/W1847353603","https://openalex.org/W1854632454","https://openalex.org/W1889002087","https://openalex.org/W1889292854","https://openalex.org/W1895169562","https://openalex.org/W1911477298","https://openalex.org/W1923159359","https://openalex.org/W1929009802","https://openalex.org/W1948948667","https://openalex.org/W1955059833","https://openalex.org/W1960160851","https://openalex.org/W1964456768","https://openalex.org/W1964473362","https://openalex.org/W1964615064","https://openalex.org/W1965646486","https://openalex.org/W1967361637","https://openalex.org/W1967412797","https://openalex.org/W1968547385","https://openalex.org/W1968672667","https://openalex.org/W1968874083","https://openalex.org/W1969347062","https://openalex.org/W1969566303","https://openalex.org/W1970102552","https://openalex.org/W1970427118","https://openalex.org/W1970595914","https://openalex.org/W1970833116","https://openalex.org/W1971006006","https://openalex.org/W1971599917","https://openalex.org/W1972558433","https://openalex.org/W1972613882","https://openalex.org/W1973017007","https://openalex.org/W1973176928","https://openalex.org/W1973896710","https://openalex.org/W1975614308","https://openalex.org/W1976463756","https://openalex.org/W1976890253","https://openalex.org/W1977114789","https://openalex.org/W1977152294","https://openalex.org/W1977314462","https://openalex.org/W1977316721","https://openalex.org/W1978162225","https://openalex.org/W1978345826","https://openalex.org/W1978411785","https://openalex.org/W1979329353","https://openalex.org/W1979659033","https://openalex.org/W1979700851","https://openalex.org/W1980762198","https://openalex.org/W1981438457","https://openalex.org/W1981492597","https://openalex.org/W1981554819","https://openalex.org/W1982468817","https://openalex.org/W1983867164","https://openalex.org/W1983967781","https://openalex.org/W1984521094","https://openalex.org/W1984903682","https://openalex.org/W1985671788","https://openalex.org/W1987152287","https://openalex.org/W1987421901","https://openalex.org/W1987453246","https://openalex.org/W1987557547","https://openalex.org/W1987577833","https://openalex.org/W1988574165","https://openalex.org/W1988803492","https://openalex.org/W1989355270","https://openalex.org/W1989365258","https://openalex.org/W1989447605","https://openalex.org/W1989514987","https://openalex.org/W1989880720","https://openalex.org/W1990257506","https://openalex.org/W1990792990","https://openalex.org/W1991869633","https://openalex.org/W1992919675","https://openalex.org/W1993566144","https://openalex.org/W1993687371","https://openalex.org/W1994259586","https://openalex.org/W1994582473","https://openalex.org/W1994794191","https://openalex.org/W1994866601","https://openalex.org/W1995050625","https://openalex.org/W1995538993","https://openalex.org/W1995588722","https://openalex.org/W1995640088","https://openalex.org/W1995688030","https://openalex.org/W1997272952","https://openalex.org/W1997318258","https://openalex.org/W1997932090","https://openalex.org/W1998071719","https://openalex.org/W1998496847","https://openalex.org/W1999696701","https://openalex.org/W2000243822","https://openalex.org/W2000287422","https://openalex.org/W2002308803","https://openalex.org/W2002899223","https://openalex.org/W2003745437","https://openalex.org/W2005010203","https://openalex.org/W2006024237","https://openalex.org/W2006104169","https://openalex.org/W2007737411","https://openalex.org/W2007797756","https://openalex.org/W2008508322","https://openalex.org/W2008528825","https://openalex.org/W2008615638","https://openalex.org/W2009452775","https://openalex.org/W2010160555","https://openalex.org/W2010332455","https://openalex.org/W2011632934","https://openalex.org/W2013381567","https://openalex.org/W2013721854","https://openalex.org/W2014683929","https://openalex.org/W2014731651","https://openalex.org/W2014767061","https://openalex.org/W2014784604","https://openalex.org/W2015149522","https://openalex.org/W2015377383","https://openalex.org/W2015615030","https://openalex.org/W2016416373","https://openalex.org/W2016613744","https://openalex.org/W2016986936","https://openalex.org/W2017129200","https://openalex.org/W2017554373","https://openalex.org/W2017800047","https://openalex.org/W2017889911","https://openalex.org/W2018228900","https://openalex.org/W2018615073","https://openalex.org/W2019594311","https://openalex.org/W2019617228","https://openalex.org/W2020741324","https://openalex.org/W2020760006","https://openalex.org/W2021516648","https://openalex.org/W2022062980","https://openalex.org/W2022744988","https://openalex.org/W2023360252","https://openalex.org/W2023379265","https://openalex.org/W2023551508","https://openalex.org/W2023666553","https://openalex.org/W2024202334","https://openalex.org/W2024505897","https://openalex.org/W2024903106","https://openalex.org/W2026289366","https://openalex.org/W2026472826","https://openalex.org/W2026898124","https://openalex.org/W2026981140","https://openalex.org/W2027234583","https://openalex.org/W2027418375","https://openalex.org/W2028627630","https://openalex.org/W2028761750","https://openalex.org/W2029706883","https://openalex.org/W2030165232","https://openalex.org/W2032694580","https://openalex.org/W2034569019","https://openalex.org/W2034602137","https://openalex.org/W2035476626","https://openalex.org/W2035620169","https://openalex.org/W2035708765","https://openalex.org/W2036224418","https://openalex.org/W2037154107","https://openalex.org/W2037211353","https://openalex.org/W2038282796","https://openalex.org/W2038600714","https://openalex.org/W2039936215","https://openalex.org/W2039949993","https://openalex.org/W2040020104","https://openalex.org/W2040069934","https://openalex.org/W2040470710","https://openalex.org/W2041582877","https://openalex.org/W2042646075","https://openalex.org/W2044261018","https://openalex.org/W2045076976","https://openalex.org/W2045984578","https://openalex.org/W2046971992","https://openalex.org/W2047610525","https://openalex.org/W2047866697","https://openalex.org/W2048988471","https://openalex.org/W2049042331","https://openalex.org/W2049370164","https://openalex.org/W2049664335","https://openalex.org/W2049783720","https://openalex.org/W2050182552","https://openalex.org/W2050497715","https://openalex.org/W2050897511","https://openalex.org/W2052097767","https://openalex.org/W2052984875","https://openalex.org/W2053347615","https://openalex.org/W2053383702","https://openalex.org/W2053533485","https://openalex.org/W2054649519","https://openalex.org/W2056382290","https://openalex.org/W2057648527","https://openalex.org/W2057897770","https://openalex.org/W2058218983","https://openalex.org/W2058431890","https://openalex.org/W2058601304","https://openalex.org/W2058755393","https://openalex.org/W2059039694","https://openalex.org/W2060333964","https://openalex.org/W2060638044","https://openalex.org/W2060831743","https://openalex.org/W2061235756","https://openalex.org/W2061405398","https://openalex.org/W2061429334","https://openalex.org/W2061518671","https://openalex.org/W2062255318","https://openalex.org/W2062397694","https://openalex.org/W2063046975","https://openalex.org/W2063816440","https://openalex.org/W2063831467","https://openalex.org/W2064058916","https://openalex.org/W2064586774","https://openalex.org/W2065203285","https://openalex.org/W2067275294","https://openalex.org/W2068096638","https://openalex.org/W2068766125","https://openalex.org/W2068905608","https://openalex.org/W2069817913","https://openalex.org/W2070849090","https://openalex.org/W2071183593","https://openalex.org/W2071393446","https://openalex.org/W2071443658","https://openalex.org/W2071475512","https://openalex.org/W2071497437","https://openalex.org/W2072892297","https://openalex.org/W2073597339","https://openalex.org/W2074894281","https://openalex.org/W2075809778","https://openalex.org/W2075907691","https://openalex.org/W2077469001","https://openalex.org/W2078467232","https://openalex.org/W2078984355","https://openalex.org/W2079041103","https://openalex.org/W2079047912","https://openalex.org/W2079593152","https://openalex.org/W2082110280","https://openalex.org/W2082473607","https://openalex.org/W2082542825","https://openalex.org/W2082702456","https://openalex.org/W2082872322","https://openalex.org/W2084201100","https://openalex.org/W2084510672","https://openalex.org/W2085097917","https://openalex.org/W2085160647","https://openalex.org/W2085250186","https://openalex.org/W2085852715","https://openalex.org/W2086041680","https://openalex.org/W2086275795","https://openalex.org/W2086745302","https://openalex.org/W2087168320","https://openalex.org/W2088055307","https://openalex.org/W2088377006","https://openalex.org/W2088728327","https://openalex.org/W2088729275","https://openalex.org/W2088923697","https://openalex.org/W2089025918","https://openalex.org/W2090303578","https://openalex.org/W2090720549","https://openalex.org/W2091193879","https://openalex.org/W2091601520","https://openalex.org/W2091821314","https://openalex.org/W2092419989","https://openalex.org/W2092942910","https://openalex.org/W2092946225","https://openalex.org/W2093009414","https://openalex.org/W2093548319","https://openalex.org/W2094214128","https://openalex.org/W2094802457","https://openalex.org/W2094855804","https://openalex.org/W2094927522","https://openalex.org/W2094945284","https://openalex.org/W2095854263","https://openalex.org/W2096114963","https://openalex.org/W2096341267","https://openalex.org/W2096352923","https://openalex.org/W2096737170","https://openalex.org/W2097355152","https://openalex.org/W2097431335","https://openalex.org/W2097489256","https://openalex.org/W2098453740","https://openalex.org/W2098828303","https://openalex.org/W2099093659","https://openalex.org/W2099882526","https://openalex.org/W2100629191","https://openalex.org/W2101356983","https://openalex.org/W2101447839","https://openalex.org/W2101919304","https://openalex.org/W2103411175","https://openalex.org/W2103466919","https://openalex.org/W2104380573","https://openalex.org/W2104475665","https://openalex.org/W2104486246","https://openalex.org/W2104823706","https://openalex.org/W2105961226","https://openalex.org/W2106105420","https://openalex.org/W2106572088","https://openalex.org/W2106929179","https://openalex.org/W2107688352","https://openalex.org/W2108619498","https://openalex.org/W2109952080","https://openalex.org/W2110279874","https://openalex.org/W2111428392","https://openalex.org/W2111704063","https://openalex.org/W2111718849","https://openalex.org/W2112081943","https://openalex.org/W2112563824","https://openalex.org/W2112726350","https://openalex.org/W2113934901","https://openalex.org/W2114257173","https://openalex.org/W2114646530","https://openalex.org/W2115153703","https://openalex.org/W2115365839","https://openalex.org/W2115713362","https://openalex.org/W2116608195","https://openalex.org/W2116825773","https://openalex.org/W2116960426","https://openalex.org/W2116962665","https://openalex.org/W2118152368","https://openalex.org/W2118212225","https://openalex.org/W2118634133","https://openalex.org/W2118722072","https://openalex.org/W2118897660","https://openalex.org/W2119455028","https://openalex.org/W2119608885","https://openalex.org/W2120553703","https://openalex.org/W2120802920","https://openalex.org/W2121349030","https://openalex.org/W2121735022","https://openalex.org/W2121815042","https://openalex.org/W2122686025","https://openalex.org/W2124284996","https://openalex.org/W2124543443","https://openalex.org/W2124579523","https://openalex.org/W2125586000","https://openalex.org/W2125678486","https://openalex.org/W2125804349","https://openalex.org/W2126567388","https://openalex.org/W2126618234","https://openalex.org/W2126834790","https://openalex.org/W2127060442","https://openalex.org/W2127538694","https://openalex.org/W2130575832","https://openalex.org/W2130678592","https://openalex.org/W2131177152","https://openalex.org/W2131577319","https://openalex.org/W2131685445","https://openalex.org/W2131901675","https://openalex.org/W2132106701","https://openalex.org/W2132812047","https://openalex.org/W2133011751","https://openalex.org/W2135739418","https://openalex.org/W2135801344","https://openalex.org/W2136815686","https://openalex.org/W2137593891","https://openalex.org/W2138170088","https://openalex.org/W2138794351","https://openalex.org/W2140015750","https://openalex.org/W2142393775","https://openalex.org/W2142408086","https://openalex.org/W2142737651","https://openalex.org/W2143339726","https://openalex.org/W2143443735","https://openalex.org/W2143827483","https://openalex.org/W2144107150","https://openalex.org/W2144583900","https://openalex.org/W2144630422","https://openalex.org/W2144703558","https://openalex.org/W2145551489","https://openalex.org/W2145879452","https://openalex.org/W2146195218","https://openalex.org/W2146727351","https://openalex.org/W2147883257","https://openalex.org/W2148408888","https://openalex.org/W2149013679","https://openalex.org/W2149874042","https://openalex.org/W2150200572","https://openalex.org/W2150600779","https://openalex.org/W2150733143","https://openalex.org/W2151396228","https://openalex.org/W2152097865","https://openalex.org/W2152762661","https://openalex.org/W2152996717","https://openalex.org/W2153953287","https://openalex.org/W2154684959","https://openalex.org/W2155043219","https://openalex.org/W2155583879","https://openalex.org/W2155866739","https://openalex.org/W2155975134","https://openalex.org/W2156433522","https://openalex.org/W2156481396","https://openalex.org/W2157756663","https://openalex.org/W2158344911","https://openalex.org/W2158990159","https://openalex.org/W2159003188","https://openalex.org/W2159045140","https://openalex.org/W2160013321","https://openalex.org/W2160539191","https://openalex.org/W2161597738","https://openalex.org/W2162386982","https://openalex.org/W2162489885","https://openalex.org/W2162804111","https://openalex.org/W2162938659","https://openalex.org/W2164313332","https://openalex.org/W2165801080","https://openalex.org/W2166192810","https://openalex.org/W2166410110","https://openalex.org/W2166752218","https://openalex.org/W2168109885","https://openalex.org/W2168444218","https://openalex.org/W2169182236","https://openalex.org/W2169429079","https://openalex.org/W2169698041","https://openalex.org/W2170276453","https://openalex.org/W2170485682","https://openalex.org/W2170625925","https://openalex.org/W2170738063","https://openalex.org/W2171832412","https://openalex.org/W2171984608","https://openalex.org/W2172016508","https://openalex.org/W2179904823","https://openalex.org/W2180153357","https://openalex.org/W2180417869","https://openalex.org/W2181683272","https://openalex.org/W2182021623","https://openalex.org/W2182234738","https://openalex.org/W2183826319","https://openalex.org/W2186114039","https://openalex.org/W2196592839","https://openalex.org/W2212848802","https://openalex.org/W2213685763","https://openalex.org/W2216871336","https://openalex.org/W2217079005","https://openalex.org/W2218177559","https://openalex.org/W2255671787","https://openalex.org/W2256934230","https://openalex.org/W2263809318","https://openalex.org/W2264211064","https://openalex.org/W2268474284","https://openalex.org/W2276964472","https://openalex.org/W2292855852","https://openalex.org/W2293743612","https://openalex.org/W2300468066","https://openalex.org/W2323358865","https://openalex.org/W2410966654","https://openalex.org/W2411259995","https://openalex.org/W2411552542","https://openalex.org/W2414107447","https://openalex.org/W2418576457","https://openalex.org/W2418968113","https://openalex.org/W2426642388","https://openalex.org/W2465193790","https://openalex.org/W2467998847","https://openalex.org/W2795146441","https://openalex.org/W3147668342","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2008559461","https://openalex.org/W7095916383","https://openalex.org/W2135613041","https://openalex.org/W2087543544","https://openalex.org/W2415543012","https://openalex.org/W2058301961","https://openalex.org/W2123716642","https://openalex.org/W189416889","https://openalex.org/W2154684959","https://openalex.org/W2096976751"],"abstract_inverted_index":{"Heart":[0],"responds":[1],"to":[2,44,241,250,270],"pathological":[3],"hemodynamic":[4,336],"stress":[5,85,337],"by":[6,31,88,169,215,224,329,359],"increasing":[7,32],"cardiac":[8,36,67,79,145,209,316],"myocyte":[9],"size,":[10],"reprogramming":[11],"gene":[12,64,80,141,199,313,321,349],"expression":[13,65,81,314,322,350],"and":[14,35,59,107,112,138,153,159,197,211,217,246,284,319,338,362],"enhancing":[15],"contractile":[16],"protein":[17],"synthesis.":[18],"Neurohumoral":[19],"factors":[20,167,332],"mediate":[21],"hypertrophic":[22],"adaptation":[23],"either":[24,188],"directly":[25],"via":[26],"specific":[27],"receptors":[28],"or":[29,91,190],"indirectly":[30],"blood":[33,212],"pressure":[34,213],"load.":[37],"The":[38],"aim":[39],"of":[40,48,72,74,174,179,195,253,277,280,295],"this":[41],"study":[42,164],"was":[43,86,239],"evaluate":[45],"the":[46,54,70,166,172,177,192,233,281,292,296,324,330,339],"role":[47,308],"angiotensin":[49],"II":[50,76,90,128,203,255,304],"(Ang":[51],"II)":[52],"in":[53,77,102,150,220,309,323,343,351,355],"atrial":[55],"natriuretic":[56,61,311],"peptide":[57,62,312],"(ANP)":[58],"B-type":[60],"(BNP)":[63],"during":[66,315,333],"overload.":[68,317],"Furthermore,":[69],"mechanisms":[71,361],"action":[73],"Ang":[75,89,127,143,175,184,202,254,293,303,334,352],"regulating":[78,310],"were":[82,181],"studied.":[83,182],"Hemodynamic":[84],"produced":[87,147,218],"nitric":[92],"oxide":[93],"(NO)":[94],"synthase":[95],"inhibitor":[96],"NG-nitro-Larginine":[97],"methyl":[98],"ester":[99],"(L-NAME)":[100],"administration":[101,117],"conscious":[103],"rats.":[104],"Despite":[105],"hypertension":[106,137,354],"increased":[108,208,264],"left":[109,124],"ventricular":[110,125,139,151,347],"ANP":[111,140,152,196,318],"BNP":[113,154,198,236,261,282,297,320,348],"mRNA":[114,155,262],"levels,":[115],"L-NAME":[116],"for":[118,205],"8":[119],"weeks":[120,207,252],"did":[121],"not":[122],"induce":[123],"hypertrophy.":[126],"type":[129],"1":[130],"receptor":[131,341],"(AT1)":[132],"antagonism":[133,342],"decreased":[134,269],"significantly":[135],"L-NAME-induced":[136],"expression.":[142],"II-induced":[144,353],"overload":[146],"significant":[148],"increase":[149,242],"levels":[156,263,272],"at":[157,243,258,265],"12":[158,259],"72":[160,274],"h,":[161],"respectively.":[162,201],"To":[163],"whether":[165],"synthesized":[168],"adrenals":[170],"modulate":[171],"response":[173],"II,":[176],"effects":[178],"adrenalectomy":[180,187],"In":[183],"II-treated":[185],"rats,":[186],"abolished":[189],"blunted":[191],"early":[193],"activation":[194],"expression,":[200],"infusion":[204],"2":[206,244,251,266],"mass":[210],"measured":[214],"telemetry,":[216],"changes":[219],"diastolic":[221],"function":[222],"detected":[223],"echocardiography.":[225],"By":[226],"using":[227],"direct":[228],"plasmid":[229],"DNA":[230,285],"injections":[231],"into":[232],"rat":[234,325],"myocardium,":[235],"promoter":[237,283],"activity":[238],"observed":[240],"h":[245,267],"remain":[247],"up-regulated":[248],"up":[249],"infusion,":[256],"except":[257],"h.":[260,275],"but":[268],"basal":[271],"after":[273],"Mutation":[276],"GATA":[278,363],"elements":[279],"binding":[286],"assays":[287],"revealed":[288],"that":[289,302],"GATA4":[290],"mediates":[291],"II-responsiveness":[294],"gene.":[298],"These":[299],"results":[300],"indicate":[301],"plays":[305],"an":[306],"important":[307],"heart":[326],"is":[327,357],"modulated":[328],"adrenal":[331],"II-stimulated":[335],"AT1":[340],"NO-deficient":[344],"hypertension.":[345],"Moreover,":[346],"vivo":[356],"controlled":[358],"posttranscriptional":[360],"elements.":[364]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}