{"id":"https://openalex.org/W2184218697","doi":null,"title":"Buprenorphine/naloxone versus methadone in opioid dependence: a longitudinal survey.","display_name":"Buprenorphine/naloxone versus methadone in opioid dependence: a longitudinal survey.","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W2184218697","mag":"2184218697","pmid":"https://pubmed.ncbi.nlm.nih.gov/21845796"},"language":"en","primary_location":{"id":"pmid:21845796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048523510","display_name":"Francesco Curcio","orcid":"https://orcid.org/0000-0002-9070-4807","observed_orcids":["https://orcid.org/0000-0002-9070-4807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Curcio","raw_affiliation_strings":["U.O. Ser.T. 31 and S.C. Tutela della Salute Dipartimento Farmacodipendenze, ASL Napoli 1 Centro, Napoli, Italy. itinerari2008@alice.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.O. Ser.T. 31 and S.C. Tutela della Salute Dipartimento Farmacodipendenze, ASL Napoli 1 Centro, Napoli, Italy. itinerari2008@alice.it","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033552692","display_name":"T\u00e9a Franco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Franco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060413907","display_name":"M Topa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Topa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051448930","display_name":"Clara Baldassarre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Baldassarre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1935,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87609545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"8","first_page":"871","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buprenorphine-naloxone","display_name":"buprenorphine/naloxone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/methadone","display_name":"methadone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/opioid-substitution-therapy","display_name":"opioid substitution therapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/treatment-retention","display_name":"treatment retention","score":0.9070000052452087},{"id":"https://openalex.org/keywords/drug-diversion","display_name":"drug diversion","score":0.5070000290870667},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.6449999809265137},{"id":"https://openalex.org/keywords/urine-toxicology","display_name":"urine toxicology","score":0.8309999704360962},{"id":"https://openalex.org/keywords/social-functioning","display_name":"social functioning","score":0.8820000290870667},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cocaine-use","display_name":"cocaine use","score":0.6140000224113464},{"id":"https://openalex.org/keywords/addiction-treatment-services","display_name":"addiction services","score":0.41600000858306885},{"id":"https://openalex.org/keywords/italy","display_name":"Italy","score":0.5220000147819519},{"id":"https://openalex.org/keywords/naples","display_name":"Naples","score":0.972000002861023},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.4300000071525574},{"id":"https://openalex.org/keywords/selection-bias","display_name":"selection bias","score":0.49000000953674316},{"id":"https://openalex.org/keywords/attrition-bias","display_name":"attrition bias","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2778949969","wikidata":"https://www.wikidata.org/wiki/Q407721","display_name":"Buprenorphine","level":4,"score":0.9622101783752441},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.922892689704895},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.8303219676017761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7414892315864563},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6095035076141357},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46406444907188416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23164206743240356},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003042","descriptor_name":"Cocaine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058850","descriptor_name":"Opiate Substitution Treatment","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21845796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},{"id":"mag:2184218697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21845796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2197703284","https://openalex.org/W2059202359","https://openalex.org/W1999644674","https://openalex.org/W2178765203","https://openalex.org/W1976869578","https://openalex.org/W2621160284","https://openalex.org/W2017627129","https://openalex.org/W2173844711","https://openalex.org/W2050443628","https://openalex.org/W2461248502"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,58],"OBJECTIVES:":[2],"Buprenorphine":[3],"and":[4,84,97,122,154,180,211,229,255,265],"methadone":[5,83,151,181,200,224,270],"are":[6,20],"widely":[7],"used":[8],"for":[9,69,102],"the":[10,42,45,51,98,137,140,178,189,199,213,247],"treatment":[11,49,91,112,146,242],"of":[12,34,44,47,108,142,177,193,198,217,223,243,249],"opioid":[13,244],"dependence,":[14],"but":[15],"their":[16,116,287],"diversion":[17],"and/or":[18],"misuse":[19],"frequent.":[21],"In":[22],"principle,":[23],"buprenorphine/naloxone":[24,52,95,155,179,194,218,241],"combination":[25,53],"therapy":[26,138],"should":[27],"be":[28],"associated":[29,257],"with":[30,50,82,87,150,163,258,269],"a":[31,126,165,206,276],"lower":[32],"frequency":[33],"drug":[35],"abuse/misuse":[36],"than":[37],"methadone.":[38],"This":[39],"study":[40],"assessed":[41],"efficacy":[43],"substitution":[46],"buprenorphine":[48,90],"in":[54,73,160,170,188,212,261],"opioid-dependent":[55],"patients.":[56],"MATERIAL":[57],"METHODS:":[59],"3812":[60],"drug-addicted":[61],"outpatients":[62],"selected":[63],"from":[64],"10":[65],"Italian":[66],"Public":[67],"Services":[68],"Addiction":[70],"(Ser.T.)":[71],"centres":[72],"Naples":[74],"(Italy)":[75],"were":[76,80,100,131,185,282],"enrolled:":[77],"3105":[78],"(81.5%)":[79],"treated":[81,162,182,195,201,219,225,250],"707":[85],"(18.5%)":[86],"buprenorphine.":[88],"The":[89,106],"was":[92,147,168],"switched":[93,290],"to":[94,119,253,285,291],"(4:1),":[96],"patients":[99,143,161,280],"followed":[101],"about":[103],"1":[104,114,134],"year.":[105],"number":[107,141],"subjects":[109,202,251],"still":[110,144],"on":[111,145],"after":[113,136],"year,":[115],"status":[117,173],"according":[118],"social,":[120],"educational":[121,190,264],"toxicologic":[123],"(assessed":[124],"by":[125],"urine":[127,232],"toxicology":[128],"test)":[129],"parameters":[130],"assessed.":[132],"RESULTS:":[133],"year":[135],"switch,":[139],"similarly":[148,252],"reduced":[149],"(2883;":[152],"-7.5%)":[153],"(632;":[156],"-10.6%;":[157],"p=0.369).":[158],"However,":[159,272],"buprenorphine/naloxone,":[164],"significant":[166],"improvement":[167,260],"reported":[169],"social":[171,262],"life":[172],"(63%":[174],"versus":[175,196,221],"39%":[176],"subjects,":[183],"respectively,":[184],"married/cohabiting":[186],"p<0.001),":[187],"level":[191],"(43%":[192],"32%":[197],"obtained":[203],"at":[204],"least":[205],"high":[207],"school":[208],"certificate,":[209],"p<0.001)":[210],"toxicological":[214,266],"conditions":[215],"(53%":[216],"subject":[220],"30%":[222],"individuals":[226],"had":[227],"opioid-":[228],"cocaine-":[230],"negative":[231],"tests,":[233],"p<0.001).":[234],"DISCUSSION:":[235],"These":[236],"preliminary":[237],"data":[238],"suggest":[239],"that":[240],"dependence":[245,289],"reduces":[246],"percentage":[248],"methadone,":[254],"is":[256],"an":[259],"life,":[263],"conditions,":[267],"compared":[268],"treatment.":[271],"we":[273],"cannot":[274],"exclude":[275],"selection":[277],"bias,":[278],"i.e.":[279],"who":[281],"more":[283],"likely":[284],"stabilize":[286],"opiate":[288],"buprenorphine/naloxone.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}