{"id":"https://openalex.org/W2184176235","doi":"https://doi.org/10.1242/dev.105.1.167","title":"Novel patterns of homeotic protein accumulation in the head of theDrosophilaembryo","display_name":"Novel patterns of homeotic protein accumulation in the head of theDrosophilaembryo","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2184176235","doi":"https://doi.org/10.1242/dev.105.1.167","mag":"2184176235","pmid":"https://pubmed.ncbi.nlm.nih.gov/2572411"},"language":"en","primary_location":{"id":"doi:10.1242/dev.105.1.167","doi":"https://doi.org/10.1242/dev.105.1.167","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.105.1.167","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112738652","display_name":"James W. Mahaffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. W. Mahaffey","raw_affiliation_strings":["Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009857097","display_name":"Robert J. Diederich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Diederich","raw_affiliation_strings":["Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037744823","display_name":"Thomas C. Kaufman","orcid":"https://orcid.org/0000-0003-1406-7671","observed_orcids":["https://orcid.org/0000-0003-1406-7671"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. C. Kaufman","raw_affiliation_strings":["Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Program in Genetics, Cellular, and Developmental Biology, Department of Biology , , Bloomington, IN 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9888,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.93044035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"105","issue":"1","first_page":"167","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeotic-genes","display_name":"homeotic genes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/drosophila-embryo","display_name":"Drosophila embryo","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sex-combs-reduced","display_name":"Sex combs reduced","score":0.9620000123977661},{"id":"https://openalex.org/keywords/deformed","display_name":"Deformed","score":0.9959999918937683},{"id":"https://openalex.org/keywords/labial","display_name":"labials","score":0.9639999866485596},{"id":"https://openalex.org/keywords/proboscipedia","display_name":"proboscipedia","score":1.0},{"id":"https://openalex.org/keywords/engrailed","display_name":"engrailed","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ventral-nerve-cord","display_name":"ventral nerve cord","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C46751350","wikidata":"https://www.wikidata.org/wiki/Q1939530","display_name":"Homeotic gene","level":4,"score":0.9690104126930237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9295506477355957},{"id":"https://openalex.org/C64632358","wikidata":"https://www.wikidata.org/wiki/Q95351881","display_name":"engrailed","level":5,"score":0.9203397035598755},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.7505944967269897},{"id":"https://openalex.org/C158944026","wikidata":"https://www.wikidata.org/wiki/Q1029020","display_name":"Ventral nerve cord","level":3,"score":0.6838185787200928},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5682098865509033},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5464540719985962},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.4325190782546997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.432275652885437},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.37728992104530334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3502223491668701},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3487226963043213},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2559855580329895},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22965648770332336},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.22646188735961914}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005801","descriptor_name":"Genes, Homeobox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006257","descriptor_name":"Head","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.105.1.167","doi":"https://doi.org/10.1242/dev.105.1.167","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.105.1.167","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:2572411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2572411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2701408613","display_name":null,"funder_award_id":"R01GM2499","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5068242931","display_name":"MOLECULAR ANALYSIS OF A GENE CONTROLLING SEGMENT NUMBER","funder_award_id":"F32GM010036","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G878527628","display_name":null,"funder_award_id":"T32 GM07447","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W66242839","https://openalex.org/W80303580","https://openalex.org/W89847511","https://openalex.org/W98782759","https://openalex.org/W115903705","https://openalex.org/W193683354","https://openalex.org/W1535427487","https://openalex.org/W1798260048","https://openalex.org/W1815472980","https://openalex.org/W1877731130","https://openalex.org/W1963601589","https://openalex.org/W1967734945","https://openalex.org/W1967734956","https://openalex.org/W1975905413","https://openalex.org/W1984713273","https://openalex.org/W1991386302","https://openalex.org/W1995112067","https://openalex.org/W1997664026","https://openalex.org/W1999702908","https://openalex.org/W2000572318","https://openalex.org/W2006788765","https://openalex.org/W2008657400","https://openalex.org/W2010542092","https://openalex.org/W2014753175","https://openalex.org/W2019340213","https://openalex.org/W2019705126","https://openalex.org/W2034019749","https://openalex.org/W2041519679","https://openalex.org/W2053352747","https://openalex.org/W2057762129","https://openalex.org/W2062890130","https://openalex.org/W2063475293","https://openalex.org/W2064251573","https://openalex.org/W2072570820","https://openalex.org/W2073555114","https://openalex.org/W2079651862","https://openalex.org/W2092432413","https://openalex.org/W2096867567","https://openalex.org/W2096881883","https://openalex.org/W2123527968","https://openalex.org/W2124429309","https://openalex.org/W2218155435","https://openalex.org/W2402535089","https://openalex.org/W4300448772"],"related_works":["https://openalex.org/W2019340213","https://openalex.org/W2123527968","https://openalex.org/W2053352747","https://openalex.org/W2096867567","https://openalex.org/W2058675983","https://openalex.org/W7099611943","https://openalex.org/W1642970809","https://openalex.org/W4376143116","https://openalex.org/W2123675639","https://openalex.org/W2012092107"],"abstract_inverted_index":{"Antibodies":[0],"that":[1,44],"specifically":[2],"recognize":[3],"proteins":[4,55,97,127,155],"encoded":[5],"by":[6],"the":[7,21,53,68,75,83,92,103,107,111,118,121,129,138,163,181,184,189,195,199,206,208,215,226],"homeotic":[8,54,79,96],"genes:":[9],"Sex":[10,124,140],"combs":[11,125,141],"reduced,":[12],"Deformed,":[13,144],"labial":[14,132],"and":[15,39,123,131,143,148,188],"proboscipedia,":[16],"were":[17,42],"used":[18,35],"to":[19,74],"follow":[20],"distribution":[22,119],"of":[23,31,52,78,106,110,120,137,151,194],"these":[24,154],"gene":[25,80],"products":[26],"during":[27,99],"embryogenesis.":[28,100],"The":[29,171],"position":[30],"engrailed-expressing":[32],"cells":[33,48],"was":[34],"as":[36],"a":[37,88,166,220],"reference":[38],"staining":[40],"conditions":[41],"established":[43],"could":[45],"distinguish,":[46],"among":[47],"expressing":[49],"engrailed,":[50],"one":[51],"or":[56],"both.":[57],"Our":[58],"observations":[59],"demonstrate":[60],"two":[61,136],"important":[62],"facts":[63],"about":[64],"establishing":[65],"identity":[66],"in":[67,72,82,91,128,158,176],"head":[69,93],"segments.":[70],"First,":[71],"contrast":[73],"overlapping":[76],"pattern":[77,90,177,210],"expression":[81],"trunk":[84],"segments,":[85,133],"we":[86],"observe":[87],"non-overlapping":[89],"for":[94],"those":[95],"required":[98],"In":[101],"contrast,":[102],"spatial":[104],"accumulation":[105],"protein":[108],"product":[109],"non-vital":[112],"proboscipedia":[113],"locus":[114],"overlaps":[115],"partially":[116],"with":[117,180],"Deformed":[122],"reduced":[126,142],"maxillary":[130],"respectively.":[134],"Second,":[135],"proteins,":[139],"have":[145],"different":[146],"dorsal":[147,190],"ventral":[149,164,185,216],"patterns":[150],"accumulation.":[152],"Dorsally,":[153],"are":[156],"expressed":[157],"segmental":[159,221],"domains":[160],"while,":[161],"within":[162,214],"region,":[165],"parasegmental":[167,209],"register":[168,222],"is":[169,211,223],"observed.":[170],"boundary":[172],"where":[173],"this":[174],"change":[175],"occurs":[178],"coincides":[179],"junction":[182],"between":[183],"neurogenic":[186],"region":[187],"epidermis.":[191,227],"After":[192],"contraction":[193],"germ":[196],"band,":[197],"when":[198],"nerve":[200,217],"cord":[201,218],"has":[202],"completely":[203],"separated":[204],"from":[205],"epidermis,":[207],"observed":[212],"only":[213],"while":[219],"maintained":[224],"throughout":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
