{"id":"https://openalex.org/W2184170652","doi":null,"title":"NEUROPROTECTIVE EFFECT OF POTENT ANTIOXIDANT LYCOPENE IN STRESS INDUCED RAT PC-12 CELLS","display_name":"NEUROPROTECTIVE EFFECT OF POTENT ANTIOXIDANT LYCOPENE IN STRESS INDUCED RAT PC-12 CELLS","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2184170652","mag":"2184170652"},"language":"en","primary_location":{"id":"mag:2184170652","doi":null,"is_oa":false,"landing_page_url":"http://www.ijpbs.net/cms/php/upload/4261_pdf.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764788474","display_name":"International Journal of Pharma and Bio Sciences","issn_l":"0975-6299","issn":["0975-6299"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697007","host_organization_name":"Ubitech Solutions","host_organization_lineage":["https://openalex.org/P4322697007"],"host_organization_lineage_names":["Ubitech Solutions"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharma and Bio Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003009204","display_name":"Nupur Srivastava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nupur Srivastava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062805967","display_name":"Deepti Dua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepti Dua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8246,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82822702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.906000018119812},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.878000020980835},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.949999988079071},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.6439999938011169},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7489701509475708},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.748832106590271},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7461199760437012},{"id":"https://openalex.org/C2780022147","wikidata":"https://www.wikidata.org/wiki/Q208130","display_name":"Lycopene","level":3,"score":0.6963766813278198},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6328839063644409},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5944972038269043},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5724620819091797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5622804760932922},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5433580875396729},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5401597619056702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5132513046264648},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.48714038729667664},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4778575301170349},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.36735406517982483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.235623300075531},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15965664386749268},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15351903438568115}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184170652","doi":null,"is_oa":false,"landing_page_url":"http://www.ijpbs.net/cms/php/upload/4261_pdf.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764788474","display_name":"International Journal of Pharma and Bio Sciences","issn_l":"0975-6299","issn":["0975-6299"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697007","host_organization_name":"Ubitech Solutions","host_organization_lineage":["https://openalex.org/P4322697007"],"host_organization_lineage_names":["Ubitech Solutions"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharma and Bio Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1581414347","https://openalex.org/W1599342152","https://openalex.org/W1982089669","https://openalex.org/W1982659608","https://openalex.org/W1983310681","https://openalex.org/W1984042925","https://openalex.org/W1984283228","https://openalex.org/W1992857521","https://openalex.org/W1998326052","https://openalex.org/W2011558575","https://openalex.org/W2012435858","https://openalex.org/W2026895985","https://openalex.org/W2030482078","https://openalex.org/W2041109030","https://openalex.org/W2046489097","https://openalex.org/W2065853716","https://openalex.org/W2066936658","https://openalex.org/W2087671512","https://openalex.org/W2088327041","https://openalex.org/W2095513659","https://openalex.org/W2101591849","https://openalex.org/W2112679668","https://openalex.org/W2126062115","https://openalex.org/W2126428406","https://openalex.org/W2126576550","https://openalex.org/W2140538410","https://openalex.org/W2154441568","https://openalex.org/W2156945415","https://openalex.org/W2165292984","https://openalex.org/W2174438281","https://openalex.org/W2989138034"],"related_works":["https://openalex.org/W1529553565","https://openalex.org/W2476410148","https://openalex.org/W2067671016","https://openalex.org/W64570600","https://openalex.org/W2125074262","https://openalex.org/W2326999355","https://openalex.org/W1977741386","https://openalex.org/W4391523471","https://openalex.org/W273079295","https://openalex.org/W2803082134"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1],"like":[2],"Parkinson's":[3],"disease":[4],"(PD),Amyotrophic":[5],"Lateral":[6],"Sclerosis":[7],"(ALS)":[8],"and":[9,20,33,63,75,103,110,122,125,158,166,187,216,242,256],"Schizophrenia":[10],"are":[11],"a":[12,42,66,171,176],"group":[13],"of":[14,27,44,61,86,90,136,161,180,230,239,271,287,299],"illness":[15],"with":[16,119,163,200,213,223,235,277,289],"diverse":[17],"clinical":[18],"importance":[19],"etiologies.":[21],"Oxidative":[22],"stress":[23],"in":[24,79,115,146,178,195,210],"which":[25,301],"production":[26],"highly":[28],"reactive":[29,34],"oxygen":[30],"species":[31,36],"(ROS)":[32],"nitrogen":[35],"(RNS)":[37],"overwhelms":[38],"antioxidant":[39,52,84,91,134,181,203,273,297],"defences,":[40],"is":[41,170],"feature":[43],"many":[45],"neurological":[46],"diseases.":[47],"Lycopene,":[48],"the":[49,59,83,88,132,237,243,254,267,296,303],"most":[50],"potent":[51],"among":[53],"various":[54],"common":[55],"carotenoids,":[56],"protects":[57],"against":[58,308],"threat":[60],"neurodegeneration":[62],"works":[64],"as":[65,94,107,218,251,264],"neuroprotective":[67],"agent":[68],"by":[69],"preventing":[70],"mitochondrial":[71],"dysfunctions,":[72],"microglia":[73],"activation":[74],"focal":[76],"cerebral":[77],"ischemia":[78],"rats.":[80],"To":[81],"study":[82],"properties":[85],"lycopene,":[87,236,300],"levels":[89,179,192,204,238,259],"enzymes":[92,241,274],"such":[93,106],"catalase":[95],"(CAT),":[96],"superoxide":[97],"dismutase":[98],"(SOD)":[99],"&":[100],"glutathione-S-transferase":[101],"(GST)":[102],"non-enzymatic":[104],"parameters":[105],"glutathione":[108],"(GSH)":[109],"lipid":[111,257],"peroxidation":[112,191,258],"were":[113,193,205,246,260,279],"analyzed":[114],"PC-12":[116,196],"cells":[117,162,197,211,221,231,288],"treated":[118,212,222],"6-hydroxydopamine":[120],"(6-OHDA)":[121],"lycopene.":[123,137,290],"DPPH":[124],"FRAP":[126],"assay":[127,145],"was":[128,140,151],"done":[129],"to":[130,207,220,233,248,253,262,266,281,295],"check":[131],"total":[133],"capacity":[135],"Cell":[138,149],"viability":[139],"also":[141,152],"determined":[142],"using":[143,154],"MTT":[144],"these":[147,240,272],"samples.":[148],"Morphology":[150],"studied":[153],"TUNEL":[155],"ASSAY":[156],"prior":[157],"after":[159,198],"treatment":[160,199,229,276,286],"6-":[164,214],"OHDA":[165,215],"Lycopene.":[167],"Since":[168],"6-OHDA":[169,224,234,278],"neurotoxic":[172,309],"agent,":[173],"it":[174],"caused":[175],"decrease":[177],"enzymes,":[182],"SOD,":[183],"CAT,":[184],"GST,":[185],"GSH":[186],"cell":[188,244],"viability.":[189],"Lipid":[190],"increased":[194,209,247],"6-OHDA.":[201],"Total":[202],"found":[206],"be":[208,293],"lycopene":[217],"compared":[219,252,265],"alone.":[225],"But":[226],"on":[227],"further":[228],"exposed":[232],"counts":[245],"nearly":[249],"80%":[250],"control":[255],"decreased":[261],"75%":[263],"control.":[268],"Altered":[269],"activities":[270],"upon":[275,285],"restored":[280],"almost":[282],"normal":[283],"level":[284],"This":[291],"may":[292],"due":[294],"property":[298],"regulated":[302],"neuronal":[304],"cells'":[305],"defense":[306],"system":[307],"shock.":[310]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}