{"id":"https://openalex.org/W2184149652","doi":null,"title":"Application of multiplex cytometric bead array technology for the measurement of angiogenic factors in the vitreous.","display_name":"Application of multiplex cytometric bead array technology for the measurement of angiogenic factors in the vitreous.","publication_year":2006,"publication_date":"2006-10-02","ids":{"openalex":"https://openalex.org/W2184149652","mag":"2184149652","pmid":"https://pubmed.ncbi.nlm.nih.gov/17093399"},"language":"en","primary_location":{"id":"pmid:17093399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17093399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112090418","display_name":"Richard Maier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Richard Maier","raw_affiliation_strings":["Department of Ophthalmology, Medical University of Graz, Graz, Austria. richardmaier@chello.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Graz, Graz, Austria. richardmaier@chello.at","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013901190","display_name":"Martin Weger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Weger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112224253","display_name":"Eva-Maria Haller\u2013Schober","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva-Maria Haller-Schober","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063900865","display_name":"Yosuf El\u2010Shabrawi","orcid":"https://orcid.org/0000-0003-1704-0183","observed_orcids":["https://orcid.org/0000-0003-1704-0183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yosuf El-Shabrawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111408088","display_name":"A. Theisl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Theisl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Alfred Barth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfred Barth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114034188","display_name":"Reingard Aigner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reingard Aigner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029297245","display_name":"Anton Haas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anton Haas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4473,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.92483349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"1143","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.1597999930381775,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.8479999899864197},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/angiogenin","display_name":"angiogenin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/elisa-comparison","display_name":"ELISA comparison","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ocular-inflammation","display_name":"ocular inflammation","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C2776719180","wikidata":"https://www.wikidata.org/wiki/Q14882120","display_name":"Angiogenin","level":3,"score":0.69964998960495},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6208921670913696},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5314651131629944},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5282520651817322},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.4497341215610504},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4374277889728546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4246722459793091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37541887164115906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34640851616859436},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34093761444091797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2514643669128418},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.11784130334854126}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17093399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17093399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Comparative Study"},{"id":"mag:2184149652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17093399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1903720360","https://openalex.org/W1967534342","https://openalex.org/W1968827381","https://openalex.org/W1973118519","https://openalex.org/W1976633649","https://openalex.org/W1985965517","https://openalex.org/W1988143227","https://openalex.org/W1995118441","https://openalex.org/W1997324775","https://openalex.org/W2017350973","https://openalex.org/W2056089533","https://openalex.org/W2075627766","https://openalex.org/W2079778876","https://openalex.org/W2080846111","https://openalex.org/W2091587700","https://openalex.org/W2093701069","https://openalex.org/W2103097055","https://openalex.org/W2118965640","https://openalex.org/W2127381835","https://openalex.org/W2133816760","https://openalex.org/W2158889667","https://openalex.org/W2169262449","https://openalex.org/W2324588265","https://openalex.org/W2417726830","https://openalex.org/W4240304626"],"related_works":["https://openalex.org/W2147973575","https://openalex.org/W2341140550","https://openalex.org/W2330901611","https://openalex.org/W2608736049","https://openalex.org/W1203128306","https://openalex.org/W2768093672","https://openalex.org/W2074653426","https://openalex.org/W2485043796","https://openalex.org/W6889989348","https://openalex.org/W2042777748"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2,138],"was":[3,62],"carried":[4],"out":[5],"to":[6,109,142,197,243],"compare":[7],"cytometric":[8,144],"bead":[9,145],"array":[10,146],"(CBA)":[11],"technology":[12,147,207,237],"with":[13,91],"conventional":[14],"enzyme":[15],"linked":[16],"immunosorbent":[17],"assay":[18],"(ELISA)":[19],"for":[20,148,167],"the":[21,124,140,149,155,189,205,209,250],"measurement":[22,150],"of":[23,29,47,52,79,98,121,123,151,183,204],"both":[24,58,173],"vitreous":[25,48,117,174,190],"and":[26,37,42,49,55,60,69,76,82,101,118,161,170,175,186,230,247],"serum":[27,50,77,119,176,194],"concentrations":[28,51,78],"interleukin-8":[30],"(IL-8),":[31],"vascular":[32],"endothelial":[33],"growth":[34],"factor":[35],"(VEGF),":[36],"angiogenin":[38],"(ANG)":[39],"in":[40,64,106,129,154,172,188,193,217,249],"diabetic":[41],"non-diabetic":[43,71,110],"patients.":[44],"METHODS:":[45],"Measurement":[46],"IL-8,":[53,80,99,168,184,245],"VEGF,":[54,81,100,169,185,246],"ANG":[56,83,102,171,187,248],"using":[57,219],"ELISA":[59,160,234],"CBA":[61,86,162,206,236],"performed":[63],"26":[65],"probands":[66],"(13":[67],"diabetics":[68,107,131],"13":[70],"control":[72,111,133,198],"subjects).":[73],"RESULTS:":[74],"Vitreous":[75,96],"determined":[84],"by":[85,94,159],"showed":[87,180],"a":[88,220,239],"strong":[89],"correlation":[90,115],"those":[92],"measured":[93,216],"ELISA.":[95],"levels":[97,120],"were":[103,127,164],"significantly":[104],"higher":[105],"compared":[108,196],"subjects.":[112,199],"No":[113],"significant":[114,181],"between":[116],"any":[122],"investigated":[125],"parameters":[126,213],"found":[128],"either":[130],"or":[132],"individuals.":[134],"CONCLUSIONS:":[135],"The":[136,200],"present":[137],"is":[139,208,226,238],"first":[141],"utilize":[143],"angiogenic":[152],"factors":[153],"vitreous.":[156,251],"Measurements":[157],"obtained":[158],"technologies":[163],"highly":[165],"correlated":[166],"samples.":[177],"Diabetic":[178],"individuals":[179],"elevation":[182],"but":[191],"not":[192],"samples":[195],"most":[201],"striking":[202],"advantage":[203],"fact":[210],"that":[211],"numerous":[212],"can":[214],"be":[215],"parallel":[218],"comparatively":[221],"small":[222],"sample":[223],"volume.":[224],"It":[225],"therefore":[227],"more":[228],"rapid":[229],"cost":[231],"effective":[232],"than":[233],"technology.":[235],"new,":[240],"accurate":[241],"method":[242],"measure":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}