{"id":"https://openalex.org/W2184148451","doi":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","title":"Effects of AT1-receptor blockade on progression of left ventricular dysfunction in dogs with heart failure","display_name":"Effects of AT1-receptor blockade on progression of left ventricular dysfunction in dogs with heart failure","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2184148451","doi":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","mag":"2184148451","pmid":"https://pubmed.ncbi.nlm.nih.gov/10199866"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1999.276.4.h1385","doi":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008689913","display_name":"Mitsuhiro Tanimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Tanimura","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088654696","display_name":"Victor G. Sharov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor G. Sharov","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015026571","display_name":"Hisashi Shimoyama","orcid":"https://orcid.org/0000-0002-6577-6681","observed_orcids":["https://orcid.org/0000-0002-6577-6681"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisashi Shimoyama","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026976387","display_name":"Takayuki Mishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takayuki Mishima","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065161269","display_name":"T. Barry Levine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802055597","display_name":"Botsford Hospital","ror":"https://ror.org/050qpjf10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802055597"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Barry Levine","raw_affiliation_strings":["Michigan Institute for Heart Failure and Transplant Care, Botsford General Hospital, Farmington Hills, Michigan 48336"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Institute for Heart Failure and Transplant Care, Botsford General Hospital, Farmington Hills, Michigan 48336","institution_ids":["https://openalex.org/I2802055597"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sidney Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sidney Goldstein","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091291156","display_name":"Hani N. Sabbah","orcid":"https://orcid.org/0000-0002-2850-6105","observed_orcids":["https://orcid.org/0000-0002-2850-6105"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani N. Sabbah","raw_affiliation_strings":["Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit 48202; and","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1651,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.87432549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"276","issue":"4","first_page":"H1385","last_page":"H1392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.34689998626708984,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/at1-receptor-blockade","display_name":"AT1 receptor blockade","score":0.847000002861023},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8820000290870667},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.996999979019165},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/coronary-microembolization","display_name":"coronary microembolization","score":0.7490000128746033},{"id":"https://openalex.org/keywords/preload-reduction","display_name":"preload reduction","score":0.5799999833106995},{"id":"https://openalex.org/keywords/afterload-reduction","display_name":"afterload reduction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.9813359975814819},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.8710938096046448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7980141639709473},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6871492266654968},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6223203539848328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5887101888656616},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4902403950691223},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4563712179660797},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.43667975068092346},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4102778732776642}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002303","descriptor_name":"Cardiac Output, Low","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002303","descriptor_name":"Cardiac Output, Low","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002303","descriptor_name":"Cardiac Output, Low","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044139","descriptor_name":"Receptor, Angiotensin, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpheart.1999.276.4.h1385","doi":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1999.276.4.h1385","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:10199866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10199866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"},{"id":"mag:2291257989","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000174965","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2180216688","display_name":null,"funder_award_id":"HL-49090-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5983708546","display_name":"PROGRESSION OF HEART FAILURE","funder_award_id":"R01HL049090","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1971323774","https://openalex.org/W1976843785","https://openalex.org/W1986644699","https://openalex.org/W1996602392","https://openalex.org/W1997602225","https://openalex.org/W1997932090","https://openalex.org/W2002899223","https://openalex.org/W2003081992","https://openalex.org/W2005816176","https://openalex.org/W2007068948","https://openalex.org/W2008125380","https://openalex.org/W2011909010","https://openalex.org/W2012444504","https://openalex.org/W2014899753","https://openalex.org/W2020103404","https://openalex.org/W2023849708","https://openalex.org/W2035691894","https://openalex.org/W2036456645","https://openalex.org/W2039055647","https://openalex.org/W2040778913","https://openalex.org/W2042525524","https://openalex.org/W2042601656","https://openalex.org/W2046664278","https://openalex.org/W2053083471","https://openalex.org/W2058755393","https://openalex.org/W2060537525","https://openalex.org/W2061743585","https://openalex.org/W2067732190","https://openalex.org/W2068989585","https://openalex.org/W2082110280","https://openalex.org/W2092171289","https://openalex.org/W2100767767","https://openalex.org/W2106929179","https://openalex.org/W2127981205","https://openalex.org/W2128963271","https://openalex.org/W2139693191","https://openalex.org/W2145879452","https://openalex.org/W2200860575","https://openalex.org/W2212747205","https://openalex.org/W2280767401","https://openalex.org/W2324321096","https://openalex.org/W2408763169","https://openalex.org/W4230893588","https://openalex.org/W4251717104","https://openalex.org/W4301499751"],"related_works":["https://openalex.org/W2062052550","https://openalex.org/W2014414469","https://openalex.org/W2008125380","https://openalex.org/W1990693905","https://openalex.org/W1976129244","https://openalex.org/W2110945278","https://openalex.org/W39505557","https://openalex.org/W2413556174","https://openalex.org/W1984505577","https://openalex.org/W336646091"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,11,25,75,175,260,292],"the":[3,9,16,23,66,258,275,290],"present":[4],"study":[5],"was":[6,61,194,207],"to":[7,72,88,99,243],"determine":[8],"effects":[10,252],"early":[12,271],"long-term":[13,272],"monotherapy":[14],"with":[15,34,45,78,109,121,178,189,218,268,274],"angiotensin":[17],"II":[18],"AT1-receptor":[19,276],"antagonist":[20],"valsartan":[21,80,90,110,278],"on":[22,253,257],"progression":[24,291],"left":[26],"ventricular":[27],"(LV)":[28],"dysfunction":[29,294],"and":[30,116,140,144,234,236,281,295],"remodeling":[31],"in":[32,42,239,246,288],"dogs":[33,44,69,184,213,267],"moderate":[35,46,269],"heart":[36],"failure":[37],"(HF).":[38],"Studies":[39],"were":[40,55,70],"performed":[41],"30":[43],"HF":[47],"produced":[48],"by":[49],"multiple":[50],"sequential":[51],"intracoronary":[52],"microembolizations.":[53],"Embolizations":[54],"discontinued":[56],"when":[57],"LV":[58,117,126,293],"ejection":[59,127,192,221],"fraction":[60,128,193,222],"30-40%.":[62],"Two":[63],"weeks":[64],"after":[65,172],"last":[67],"embolization,":[68],"randomized":[71],"3":[73,162,166,173,187,216],"mo":[74,174,188,217],"oral":[76],"therapy":[77,273],"low-dose":[79,190],"(400":[81],"mg":[82,92],"twice":[83,93],"daily,":[84,94],"n":[85,95,105],"=":[86,96,106,138,169,232],"10),":[87,97],"high-dose":[89,219],"(800":[91],"or":[98,256],"no":[100,250],"treatment":[101],"at":[102],"all":[103],"(control,":[104],"10).":[107],"Treatment":[108],"significantly":[111],"reduced":[112],"mean":[113],"aortic":[114],"pressure":[115,119],"end-diastolic":[118,145],"compared":[120,177],"control.":[122],"In":[123,183,212],"untreated":[124],"dogs,":[125],"decreased":[129,223],"(37":[130,196],"+/-":[131,135,150,154,161,165,197,201,225,229],"1":[132,198,226],"vs.":[133,152,163,199,204,227],"29":[134],"1%,":[136],"P":[137,157,168,231],"0.001)":[139],"end-systolic":[141],"volume":[142,146],"(ESV)":[143],"(EDV)":[147],"increased":[148,238],"(81":[149],"5":[151,155],"92":[153],"ml,":[156,167],"<":[158],"0.001;":[159],"51":[160],"65":[164],"0.001,":[170],"respectively)":[171],"follow-up":[176],"those":[179,244],"levels":[180,245],"before":[181],"follow-up.":[182],"treated":[185,214],"for":[186,215,266],"valsartan,":[191,220],"preserved":[195],"38":[200],"2%,":[202,230],"pretreatment":[203],"posttreatment)":[205],"as":[206],"ESV":[208,235],"but":[209,283],"not":[210],"EDV.":[211],"(35":[224],"31":[228],"0.02)":[233],"EDV":[237],"a":[240],"manner":[241],"comparable":[242],"controls.":[247],"Valsartan":[248],"had":[249],"significant":[251],"cardiomyocyte":[254],"hypertrophy":[255],"extent":[259],"interstitial":[261],"fibrosis.":[262],"We":[263],"conclude":[264],"that,":[265],"HF,":[270],"blocker":[277],"decreases":[279],"preload":[280],"afterload":[282],"has":[284],"only":[285],"limited":[286],"benefits":[287],"attenuating":[289],"chamber":[296],"remodeling.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
