{"id":"https://openalex.org/W2184139447","doi":null,"title":"Validation of a Gene-Expression Based Assay for BRCA1 Function","display_name":"Validation of a Gene-Expression Based Assay for BRCA1 Function","publication_year":2013,"publication_date":"2013-09-26","ids":{"openalex":"https://openalex.org/W2184139447","mag":"2184139447"},"language":"en","primary_location":{"id":"pmh:oai:queensu.scholaris.ca:1974/8326","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1974/8326","pdf_url":null,"source":{"id":"https://openalex.org/S4306402568","display_name":"QSpace (Queen's University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204722609","host_organization_name":"Queen's University","host_organization_lineage":["https://openalex.org/I204722609"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017190082","display_name":"Paolo Uy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paolo Uy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017190082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-expression-assay","display_name":"gene expression assay","score":0.8429999947547913},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5609999895095825},{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5543472170829773},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5208054780960083},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46123385429382324},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4328978657722473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4115782678127289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38421040773391724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3566727042198181},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3558127284049988},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29210519790649414},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09848159551620483}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:queensu.scholaris.ca:1974/8326","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1974/8326","pdf_url":null,"source":{"id":"https://openalex.org/S4306402568","display_name":"QSpace (Queen's University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204722609","host_organization_name":"Queen's University","host_organization_lineage":["https://openalex.org/I204722609"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2184139447","doi":null,"is_oa":false,"landing_page_url":"https://qspace.library.queensu.ca/bitstream/1974/8326/1/Uy_Paolo%20Miguel_201309_MSC.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":170,"referenced_works":["https://openalex.org/W115888674","https://openalex.org/W195111529","https://openalex.org/W1489337029","https://openalex.org/W1491459594","https://openalex.org/W1492305306","https://openalex.org/W1514592277","https://openalex.org/W1525705827","https://openalex.org/W1549547841","https://openalex.org/W1574011925","https://openalex.org/W1611268078","https://openalex.org/W1707889259","https://openalex.org/W1768635289","https://openalex.org/W1821305326","https://openalex.org/W1860025132","https://openalex.org/W1887764107","https://openalex.org/W1902704112","https://openalex.org/W1910923123","https://openalex.org/W1965156081","https://openalex.org/W1967261754","https://openalex.org/W1968410967","https://openalex.org/W1968428572","https://openalex.org/W1969150779","https://openalex.org/W1971188337","https://openalex.org/W1971613814","https://openalex.org/W1973803589","https://openalex.org/W1974224833","https://openalex.org/W1976960697","https://openalex.org/W1978331091","https://openalex.org/W1980450624","https://openalex.org/W1984431444","https://openalex.org/W1984592335","https://openalex.org/W1985303436","https://openalex.org/W1985481481","https://openalex.org/W1986921213","https://openalex.org/W1989059483","https://openalex.org/W1989290124","https://openalex.org/W1989778317","https://openalex.org/W1989841784","https://openalex.org/W1990257935","https://openalex.org/W1992876574","https://openalex.org/W1998605540","https://openalex.org/W1999067978","https://openalex.org/W2000636252","https://openalex.org/W2001638985","https://openalex.org/W2002120623","https://openalex.org/W2004935367","https://openalex.org/W2005814109","https://openalex.org/W2010281502","https://openalex.org/W2011094690","https://openalex.org/W2011152694","https://openalex.org/W2011275324","https://openalex.org/W2013743651","https://openalex.org/W2015357565","https://openalex.org/W2017714068","https://openalex.org/W2019089605","https://openalex.org/W2019405732","https://openalex.org/W2021227878","https://openalex.org/W2022937116","https://openalex.org/W2025075293","https://openalex.org/W2025616449","https://openalex.org/W2026007913","https://openalex.org/W2027605814","https://openalex.org/W2027922677","https://openalex.org/W2032298890","https://openalex.org/W2032780125","https://openalex.org/W2036124507","https://openalex.org/W2036750803","https://openalex.org/W2038004167","https://openalex.org/W2038576667","https://openalex.org/W2039478924","https://openalex.org/W2041205258","https://openalex.org/W2041334042","https://openalex.org/W2042252846","https://openalex.org/W2044898649","https://openalex.org/W2048875557","https://openalex.org/W2049598883","https://openalex.org/W2050781188","https://openalex.org/W2053003311","https://openalex.org/W2053177037","https://openalex.org/W2054245896","https://openalex.org/W2055952604","https://openalex.org/W2056604321","https://openalex.org/W2059569390","https://openalex.org/W2060184174","https://openalex.org/W2062229879","https://openalex.org/W2063281610","https://openalex.org/W2064616338","https://openalex.org/W2065520466","https://openalex.org/W2068638854","https://openalex.org/W2071282471","https://openalex.org/W2074844264","https://openalex.org/W2075059258","https://openalex.org/W2075187323","https://openalex.org/W2075582201","https://openalex.org/W2077709632","https://openalex.org/W2082326948","https://openalex.org/W2087025655","https://openalex.org/W2088179903","https://openalex.org/W2088497696","https://openalex.org/W2089218510","https://openalex.org/W2090740451","https://openalex.org/W2093155634","https://openalex.org/W2093385884","https://openalex.org/W2095311803","https://openalex.org/W2096269949","https://openalex.org/W2098161480","https://openalex.org/W2100237364","https://openalex.org/W2100868970","https://openalex.org/W2101617798","https://openalex.org/W2103019838","https://openalex.org/W2103673770","https://openalex.org/W2103970959","https://openalex.org/W2106095322","https://openalex.org/W2106483643","https://openalex.org/W2106662858","https://openalex.org/W2106976977","https://openalex.org/W2107130407","https://openalex.org/W2107277218","https://openalex.org/W2109465247","https://openalex.org/W2111170941","https://openalex.org/W2111607055","https://openalex.org/W2112241022","https://openalex.org/W2112251186","https://openalex.org/W2117342688","https://openalex.org/W2119482229","https://openalex.org/W2120641928","https://openalex.org/W2121619780","https://openalex.org/W2123694831","https://openalex.org/W2125819717","https://openalex.org/W2127239016","https://openalex.org/W2128199918","https://openalex.org/W2128761168","https://openalex.org/W2129169382","https://openalex.org/W2129634719","https://openalex.org/W2130952513","https://openalex.org/W2131994307","https://openalex.org/W2133643647","https://openalex.org/W2133670454","https://openalex.org/W2135964148","https://openalex.org/W2136124662","https://openalex.org/W2136464548","https://openalex.org/W2137579126","https://openalex.org/W2140930673","https://openalex.org/W2141069009","https://openalex.org/W2147887202","https://openalex.org/W2151601375","https://openalex.org/W2154156196","https://openalex.org/W2155547021","https://openalex.org/W2155612034","https://openalex.org/W2155675893","https://openalex.org/W2156077962","https://openalex.org/W2157570211","https://openalex.org/W2159137674","https://openalex.org/W2159468818","https://openalex.org/W2160250202","https://openalex.org/W2162727767","https://openalex.org/W2163754591","https://openalex.org/W2163929131","https://openalex.org/W2164890615","https://openalex.org/W2166247816","https://openalex.org/W2166519707","https://openalex.org/W2167711236","https://openalex.org/W2168225429","https://openalex.org/W2169630006","https://openalex.org/W2327319275","https://openalex.org/W2410808395","https://openalex.org/W2416580139","https://openalex.org/W2548572798","https://openalex.org/W2586468556","https://openalex.org/W4302794985"],"related_works":["https://openalex.org/W2557521580","https://openalex.org/W2548572798","https://openalex.org/W7113409086","https://openalex.org/W7037655060","https://openalex.org/W2550606565","https://openalex.org/W7074036780","https://openalex.org/W1044618772","https://openalex.org/W2288391687","https://openalex.org/W2469559518","https://openalex.org/W2254834618"],"abstract_inverted_index":{"Thesis":[0],"(Master,":[1],"Pathology":[2],"&":[3],"Molecular":[4],"Medicine)":[5],"--":[6],"Queen's":[7],"University,":[8],"2013-09-26":[9],"13:13:50.809":[10]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}