{"id":"https://openalex.org/W2184099401","doi":null,"title":"7 of DNA Replication","display_name":"7 of DNA Replication","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2184099401","mag":"2184099401"},"language":"en","primary_location":{"id":"mag:2184099401","doi":null,"is_oa":false,"landing_page_url":"http://dnareplication.cshl.edu/content/free/chapters/07_roberts.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101776165","display_name":"John D. Roberts","orcid":"https://orcid.org/0000-0003-2020-6201","observed_orcids":["https://orcid.org/0000-0003-2020-6201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Roberts","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2020-6201","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090158665","display_name":"Thomas A. Kunke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Kunke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14731148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-replication-fidelity","display_name":"DNA replication fidelity","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-polymerase","display_name":"DNA polymerase","score":0.6380000114440918},{"id":"https://openalex.org/keywords/exonuclease-proofreading","display_name":"exonuclease proofreading","score":0.8859999775886536},{"id":"https://openalex.org/keywords/carcinogen-dna-adducts","display_name":"carcinogen-DNA adducts","score":0.699999988079071},{"id":"https://openalex.org/keywords/spontaneous-mutation-rate","display_name":"spontaneous mutation rate","score":0.6240000128746033},{"id":"https://openalex.org/keywords/eukaryotic-dna-polymerases","display_name":"eukaryotic DNA polymerases","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C170748874","wikidata":"https://www.wikidata.org/wiki/Q21117977","display_name":"Proofreading","level":4,"score":0.7447812557220459},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.616468071937561},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5719298124313354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5557345151901245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5243749618530273},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.5040644407272339},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.451865017414093},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4499460756778717},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.4241943955421448},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42154833674430847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4038083851337433},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3497368097305298},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3488377034664154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1329067051410675}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2184099401","doi":null,"is_oa":false,"landing_page_url":"http://dnareplication.cshl.edu/content/free/chapters/07_roberts.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W7146285","https://openalex.org/W32978508","https://openalex.org/W61650054","https://openalex.org/W69782026","https://openalex.org/W78111501","https://openalex.org/W159668801","https://openalex.org/W1481052392","https://openalex.org/W1484882395","https://openalex.org/W1490908705","https://openalex.org/W1496145660","https://openalex.org/W1499552914","https://openalex.org/W1501062003","https://openalex.org/W1520197177","https://openalex.org/W1524248891","https://openalex.org/W1524319516","https://openalex.org/W1532514832","https://openalex.org/W1533555842","https://openalex.org/W1535282352","https://openalex.org/W1539404499","https://openalex.org/W1545429574","https://openalex.org/W1552840552","https://openalex.org/W1553993431","https://openalex.org/W1558506222","https://openalex.org/W1560153625","https://openalex.org/W1563965033","https://openalex.org/W1565369530","https://openalex.org/W1569389754","https://openalex.org/W1572281772","https://openalex.org/W1576472122","https://openalex.org/W1585849424","https://openalex.org/W1590831713","https://openalex.org/W1590941444","https://openalex.org/W1602454738","https://openalex.org/W1605349427","https://openalex.org/W1608869439","https://openalex.org/W1624763535","https://openalex.org/W1651950734","https://openalex.org/W1656176238","https://openalex.org/W1703028909","https://openalex.org/W1770654987","https://openalex.org/W1873610357","https://openalex.org/W1889077695","https://openalex.org/W1894612901","https://openalex.org/W1965072222","https://openalex.org/W1967460034","https://openalex.org/W1967629365","https://openalex.org/W1969826188","https://openalex.org/W1970321104","https://openalex.org/W1975828313","https://openalex.org/W1978626016","https://openalex.org/W1979511146","https://openalex.org/W1983385891","https://openalex.org/W1984290310","https://openalex.org/W1987305037","https://openalex.org/W1989341969","https://openalex.org/W1993663419","https://openalex.org/W1995250794","https://openalex.org/W2000034252","https://openalex.org/W2003359762","https://openalex.org/W2008468660","https://openalex.org/W2009230970","https://openalex.org/W2011263411","https://openalex.org/W2011719683","https://openalex.org/W2016721288","https://openalex.org/W2017044906","https://openalex.org/W2017950533","https://openalex.org/W2019650070","https://openalex.org/W2019918748","https://openalex.org/W2020152372","https://openalex.org/W2022280116","https://openalex.org/W2026427972","https://openalex.org/W2029739253","https://openalex.org/W2031842720","https://openalex.org/W2034035353","https://openalex.org/W2036181470","https://openalex.org/W2036615609","https://openalex.org/W2036645220","https://openalex.org/W2047171147","https://openalex.org/W2047388928","https://openalex.org/W2047615889","https://openalex.org/W2049601212","https://openalex.org/W2050455558","https://openalex.org/W2055097794","https://openalex.org/W2055348937","https://openalex.org/W2058825091","https://openalex.org/W2059271329","https://openalex.org/W2059946255","https://openalex.org/W2068130878","https://openalex.org/W2072993432","https://openalex.org/W2074507088","https://openalex.org/W2076178794","https://openalex.org/W2076572085","https://openalex.org/W2077132202","https://openalex.org/W2080028600","https://openalex.org/W2084147994","https://openalex.org/W2085060564","https://openalex.org/W2085719635","https://openalex.org/W2086447257","https://openalex.org/W2098697496","https://openalex.org/W2108150290","https://openalex.org/W2118621400","https://openalex.org/W2120902002","https://openalex.org/W2138398063","https://openalex.org/W2138476183","https://openalex.org/W2145782917","https://openalex.org/W2157114285","https://openalex.org/W2160771664","https://openalex.org/W2163043365","https://openalex.org/W2173813643","https://openalex.org/W2173897158","https://openalex.org/W2185952256","https://openalex.org/W2322672979","https://openalex.org/W2412649504","https://openalex.org/W2416194960","https://openalex.org/W2462318323"],"related_works":["https://openalex.org/W7095783907","https://openalex.org/W428322636","https://openalex.org/W2528962336","https://openalex.org/W7098436004","https://openalex.org/W2111765629","https://openalex.org/W56149967","https://openalex.org/W2076178794","https://openalex.org/W2164447702","https://openalex.org/W2133606537","https://openalex.org/W2285487864"],"abstract_inverted_index":{"The":[0],"six":[1],"billion":[2],"nucleotides":[3],"of":[4,51,68,72,109,113,117,164],"the":[5,22,48,69,93,96,110,114,149,153],"diploid":[6],"human":[7],"genome":[8,33],"are":[9,81],"replicated":[10],"in":[11,77,95],"only":[12],"a":[13,84],"few":[14,19],"hours":[15],"while":[16],"generating":[17],"so":[18],"errors":[20,128],"that":[21,100],"spontaneous":[23],"mutation":[24,31],"rate":[25],"may":[26],"be":[27],"less":[28],"than":[29],"1":[30],"per":[32,34],"cell":[35],"division":[36],"(Loeb":[37],"1991).":[38],"This":[39],"incredible":[40],"accuracy":[41],"results":[42],"from":[43],"three":[44],"major":[45],"erroravoidance":[46],"processes:":[47],"high":[49],"selectivity":[50],"DNA":[52,119,139,159,161],"polymerases,":[53],"exonucleolytic":[54],"proofreading,":[55],"and":[56,132,160],"postreplication":[57],"mismatch":[58,79],"repair.":[59],"In":[60],"this":[61],"chapter,":[62],"we":[63,145],"review":[64,86,107,133],"our":[65],"current":[66],"understanding":[67],"first":[70],"two":[71],"these":[73],"processes.":[74],"Readers":[75],"interested":[76],"eukaryotic":[78,118,138],"repair":[80],"referred":[82],"to":[83,126],"recent":[85],"(Modrich":[87],"1994).":[88],"We":[89,121],"begin":[90],"by":[91,129],"describing":[92],"steps":[94],"polymerization":[97],"reaction":[98],"cycle":[99],"discriminate":[101],"against":[102],"base":[103],"substitution":[104,111],"errors,":[105],"then":[106,122],"studies":[108],"fidelity":[112,150],"five":[115],"classes":[116],"polymerases.":[120],"consider":[123],"several":[124],"ways":[125],"make":[127],"templateprimer":[130],"slippage":[131],"what":[134],"is":[135],"known":[136,165],"about":[137],"polymerase":[140],"frameshift":[141],"error":[142],"rates.":[143],"Finally,":[144],"present":[146],"information":[147],"on":[148],"with":[151],"which":[152],"multiprotein":[154],"replication":[155],"machinery":[156],"replicates":[157],"undamaged":[158],"containing":[162],"adducts":[163],"carcinogens.":[166]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
