{"id":"https://openalex.org/W2183868396","doi":null,"title":"Analytic Reviews: Management of Aminoglycosides in the Intensive Care Unit","display_name":"Analytic Reviews: Management of Aminoglycosides in the Intensive Care Unit","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2183868396","mag":"2183868396"},"language":"en","primary_location":{"id":"mag:2183868396","doi":null,"is_oa":false,"landing_page_url":"http://clinicalevidence.pbworks.com/w/file/fetch/30236729/AMINOGLUCOSIDOS.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042649470","display_name":"Elizabeth Radigan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Radigan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055520848","display_name":"Neil A. Gilchrist","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil A. Gilchrist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101710351","display_name":"Melissa A. Miller","orcid":"https://orcid.org/0000-0003-3985-7485","observed_orcids":["https://orcid.org/0000-0003-3985-7485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa A. Miller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3985-7485","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2186,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57708367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.996999979019165},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7229999899864197},{"id":"https://openalex.org/keywords/fluoroquinolone-resistance","display_name":"fluoroquinolone resistance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.9769999980926514},{"id":"https://openalex.org/keywords/extended-dosing-interval","display_name":"extended dosing interval","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8840000033378601},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":1.0},{"id":"https://openalex.org/keywords/serum-drug-monitoring","display_name":"serum drug concentration monitoring","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hospital-acquired-pneumonia","display_name":"nosocomial pneumonia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/endocarditis","display_name":"endocarditis","score":0.902999997138977},{"id":"https://openalex.org/keywords/intra-abdominal-infection","display_name":"intra-abdominal infection","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.7189306020736694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6907300353050232},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6175310611724854},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.5803912878036499},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.524064302444458},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.5185176134109497},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.509678840637207},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.5049636960029602},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.44770127534866333},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.4452793598175049},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.41746050119400024},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.41369596123695374},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37868550419807434},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.29141056537628174},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24213668704032898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2408750355243683},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.12089338898658752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.103586345911026},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183868396","doi":null,"is_oa":false,"landing_page_url":"http://clinicalevidence.pbworks.com/w/file/fetch/30236729/AMINOGLUCOSIDOS.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":132,"referenced_works":["https://openalex.org/W9461323","https://openalex.org/W65113315","https://openalex.org/W112455198","https://openalex.org/W122975140","https://openalex.org/W1605369936","https://openalex.org/W1606751720","https://openalex.org/W1711288256","https://openalex.org/W1950543547","https://openalex.org/W1955530400","https://openalex.org/W1963748741","https://openalex.org/W1965592831","https://openalex.org/W1973439187","https://openalex.org/W1974637030","https://openalex.org/W1975309839","https://openalex.org/W1975326190","https://openalex.org/W1976043895","https://openalex.org/W1977414628","https://openalex.org/W1978472239","https://openalex.org/W1980982717","https://openalex.org/W1982350853","https://openalex.org/W1982698885","https://openalex.org/W1983255179","https://openalex.org/W1983397305","https://openalex.org/W1984838924","https://openalex.org/W1990483077","https://openalex.org/W1991119253","https://openalex.org/W1992505948","https://openalex.org/W1993397663","https://openalex.org/W2002249283","https://openalex.org/W2003696703","https://openalex.org/W2004026051","https://openalex.org/W2006605675","https://openalex.org/W2006895725","https://openalex.org/W2011219480","https://openalex.org/W2011818075","https://openalex.org/W2014538363","https://openalex.org/W2015812881","https://openalex.org/W2017363918","https://openalex.org/W2019905097","https://openalex.org/W2023375971","https://openalex.org/W2024216342","https://openalex.org/W2025127984","https://openalex.org/W2027169933","https://openalex.org/W2027799176","https://openalex.org/W2030168088","https://openalex.org/W2034013438","https://openalex.org/W2035284381","https://openalex.org/W2036497773","https://openalex.org/W2039355480","https://openalex.org/W2041527531","https://openalex.org/W2042130235","https://openalex.org/W2042157055","https://openalex.org/W2044032759","https://openalex.org/W2047051639","https://openalex.org/W2048478051","https://openalex.org/W2051568769","https://openalex.org/W2052865703","https://openalex.org/W2058386504","https://openalex.org/W2060563399","https://openalex.org/W2060609953","https://openalex.org/W2061194988","https://openalex.org/W2063213967","https://openalex.org/W2064187936","https://openalex.org/W2066207944","https://openalex.org/W2067441755","https://openalex.org/W2071582918","https://openalex.org/W2072984719","https://openalex.org/W2073595001","https://openalex.org/W2073958994","https://openalex.org/W2076972411","https://openalex.org/W2078114493","https://openalex.org/W2083732042","https://openalex.org/W2085721202","https://openalex.org/W2086631880","https://openalex.org/W2087725305","https://openalex.org/W2090642347","https://openalex.org/W2090785276","https://openalex.org/W2093796184","https://openalex.org/W2095331130","https://openalex.org/W2097945561","https://openalex.org/W2100907980","https://openalex.org/W2101815744","https://openalex.org/W2104337600","https://openalex.org/W2107901800","https://openalex.org/W2108379671","https://openalex.org/W2113123716","https://openalex.org/W2113749492","https://openalex.org/W2116214229","https://openalex.org/W2117496821","https://openalex.org/W2118546214","https://openalex.org/W2118677651","https://openalex.org/W2118858814","https://openalex.org/W2123193104","https://openalex.org/W2124706510","https://openalex.org/W2126874955","https://openalex.org/W2128163379","https://openalex.org/W2128552228","https://openalex.org/W2129266432","https://openalex.org/W2129290348","https://openalex.org/W2129868442","https://openalex.org/W2130573966","https://openalex.org/W2132491970","https://openalex.org/W2133990815","https://openalex.org/W2138745304","https://openalex.org/W2141994303","https://openalex.org/W2143165903","https://openalex.org/W2143206150","https://openalex.org/W2144105812","https://openalex.org/W2144999694","https://openalex.org/W2147812473","https://openalex.org/W2148153258","https://openalex.org/W2152754889","https://openalex.org/W2155157210","https://openalex.org/W2158350453","https://openalex.org/W2158873221","https://openalex.org/W2158889234","https://openalex.org/W2159922699","https://openalex.org/W2166858780","https://openalex.org/W2167385770","https://openalex.org/W2167768564","https://openalex.org/W2168259885","https://openalex.org/W2169005164","https://openalex.org/W2170898681","https://openalex.org/W2171039477","https://openalex.org/W2268865174","https://openalex.org/W2314540694","https://openalex.org/W2317332612","https://openalex.org/W2318694356","https://openalex.org/W2338790966","https://openalex.org/W2398868417","https://openalex.org/W2418042788","https://openalex.org/W2475122591"],"related_works":["https://openalex.org/W2007270891","https://openalex.org/W2159320641","https://openalex.org/W28270894","https://openalex.org/W2052020700","https://openalex.org/W2331079303","https://openalex.org/W4211136259","https://openalex.org/W2329425207","https://openalex.org/W2409077461","https://openalex.org/W4253093803","https://openalex.org/W1984363401"],"abstract_inverted_index":{"Antibacterial":[0],"resistance":[1,23],"is":[2,13],"increasing":[3,19],"throughout":[4],"the":[5,8,18,92],"world,":[6],"while":[7],"development":[9],"of":[10,21,94,111,124],"new":[11],"agents":[12,39,61],"slowly":[14],"progressing.":[15],"In":[16],"addition,":[17],"prevalence":[20],"fluoroquinolone":[22],"may":[24,62,115],"force":[25],"many":[26],"practitioners":[27],"to":[28,53,75,81],"choose":[29],"an":[30],"aminoglycoside":[31,112],"agent":[32],"in":[33],"gram-negative":[34,44],"regimens.":[35],"Aminoglycosides":[36],"are":[37,108],"bactericidal":[38],"with":[40,86,118],"potent":[41],"activity":[42,47],"against":[43,48],"infections":[45,50],"and":[46,78,98,103,106,121],"gram-positive":[49],"when":[51],"added":[52],"a":[54,67],"cell":[55],"wall":[56],"active":[57],"antimicrobial-based":[58],"regimen.":[59],"These":[60],"be":[63,116],"dosed":[64],"multiple":[65],"times":[66],"day":[68],"or":[69],"consolidated":[70],"as":[71],"high-dose,":[72],"extended-interval":[73],"dosing":[74],"maximize":[76],"pharmacokinetic":[77],"pharmacodynamic":[79],"properties":[80],"achieve":[82],"possible":[83],"improved":[84],"efficacy":[85],"reduced":[87],"toxicity.":[88],"Clinical":[89],"application":[90],"includes":[91],"treatment":[93],"bacteremia,":[95],"endocarditis,":[96],"health-care":[97],"nosocomial":[99],"pneumonias,":[100],"intra-abdominal":[101],"infections,":[102],"others.":[104],"Nephrotoxicity":[105],"ototoxicity":[107],"potential":[109],"risks":[110],"therapy":[113],"that":[114],"minimized":[117],"serum":[119],"monitoring":[120],"short":[122],"courses":[123],"therapy.":[125]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
