{"id":"https://openalex.org/W2183854062","doi":null,"title":"Insulin resistance is triggered by oxidative stress in mildly obese men","display_name":"Insulin resistance is triggered by oxidative stress in mildly obese men","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2183854062","mag":"2183854062"},"language":"en","primary_location":{"id":"mag:2183854062","doi":null,"is_oa":false,"landing_page_url":"http://www.jofamericanscience.org/journals/am-sci/am0609/69_3537am0609_604_611.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009533105","display_name":"Mohammed Rehan","orcid":"https://orcid.org/0000-0002-0124-2816","observed_orcids":["https://orcid.org/0000-0002-0124-2816"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohammed Rehan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0124-2816","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009533105"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.25290000438690186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mild-obesity","display_name":"mild obesity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9710000157356262},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.9319999814033508},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8320000171661377},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.996999979019165},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8800593614578247},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8749853372573853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8427177667617798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7736459970474243},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7397743463516235},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.7307515144348145},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.580277681350708},{"id":"https://openalex.org/C2778535154","wikidata":"https://www.wikidata.org/wiki/Q5889863","display_name":"Homeostatic model assessment","level":4,"score":0.567760169506073},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.5312744379043579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5019466876983643},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4888302683830261},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.44118836522102356}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183854062","doi":null,"is_oa":false,"landing_page_url":"http://www.jofamericanscience.org/journals/am-sci/am0609/69_3537am0609_604_611.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W81051804","https://openalex.org/W1272300955","https://openalex.org/W1504301934","https://openalex.org/W1963866655","https://openalex.org/W1967964480","https://openalex.org/W1976422365","https://openalex.org/W1984513597","https://openalex.org/W1988666864","https://openalex.org/W1992670563","https://openalex.org/W1994531379","https://openalex.org/W1999223940","https://openalex.org/W2003659422","https://openalex.org/W2004994776","https://openalex.org/W2011419421","https://openalex.org/W2014887370","https://openalex.org/W2017058462","https://openalex.org/W2048565941","https://openalex.org/W2049501468","https://openalex.org/W2054931905","https://openalex.org/W2060157112","https://openalex.org/W2067743571","https://openalex.org/W2068592405","https://openalex.org/W2075125837","https://openalex.org/W2083990676","https://openalex.org/W2088208009","https://openalex.org/W2091272291","https://openalex.org/W2110504186","https://openalex.org/W2116782440","https://openalex.org/W2119210469","https://openalex.org/W2120881026","https://openalex.org/W2133224653","https://openalex.org/W2133795831","https://openalex.org/W2164846176","https://openalex.org/W2171814772","https://openalex.org/W2171819775","https://openalex.org/W2238050922","https://openalex.org/W2274791058","https://openalex.org/W2387632469","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2004994776","https://openalex.org/W2306126106","https://openalex.org/W4387380777","https://openalex.org/W2342254081","https://openalex.org/W2108292604","https://openalex.org/W109817387","https://openalex.org/W2128991504","https://openalex.org/W3185323940","https://openalex.org/W2006578694","https://openalex.org/W2911641091"],"abstract_inverted_index":{"Recent":[0],"reports":[1],"indicate":[2],"that":[3,10,24],"obesity":[4,52],"may":[5,28,223],"induce":[6],"systemic":[7],"oxidative":[8,26,48,198],"stress":[9,27,49,199],"plays":[11],"a":[12],"critical":[13],"role":[14],"in":[15,33,36,56,68,161,184,220,233],"the":[16,44,202,228],"pathogenesis":[17],"of":[18,47,85,102,107,120,192,230,238],"various":[19],"diseases.":[20],"Cumulative":[21],"evidence":[22],"suggests":[23],"increased":[25,197],"lead":[29],"to":[30,42,172,207,209,215,226],"insulin":[31,54,86,211,218,231],"resistance":[32,55,87,219,232],"vivo":[34],"or":[35],"vitro.":[37],"The":[38,58,117,190],"present":[39],"study":[40,194],"aimed":[41],"investigate":[43],"possible":[45],"relationship":[46,78],"with":[50,81,126,147,177,201],"mild":[51],"and":[53,62,72,76,92,104,164,181,187,213,217,222],"men.":[57,166,189,236],"serum":[59,100,118],"levels":[60,106,119],"malondialdehyde":[61,103,121],"total":[63,108,140],"antioxidant":[64,109,141],"capacity":[65,110,142],"were":[66,122,170],"measured":[67],"31":[69],"mildly":[70,234],"obese":[71,235],"26":[73],"nonobese":[74,112],"men":[75,96,113],"their":[77],"was":[79,143],"evaluated":[80],"homeostasis":[82],"model":[83],"assessment":[84],"(HOMA-IR),":[88],"body":[89,128,149,178],"mass":[90,129,150,179],"index":[91,130,151,180],"waist":[93,182],"circumference.":[94],"Obese":[95],"had":[97],"significantly":[98,123,144,174],"higher":[99],"concentrations":[101],"lower":[105],"than":[111],"(P":[114],"<":[115,136,159],"0.001).":[116],"positive":[124,175],"correlated":[125,146,176],"HOMA-IR,":[127,148],"(r":[131,152],"=":[132,153],"0.78;":[133],"0.69;":[134],"P":[135,158],"0.001":[137],"respectively),":[138],"while":[139],"negative":[145],"-":[154,156],"0.50;":[155],"0.64":[157],"0.001)":[160],"all":[162,185],"(obese":[163,186],"nonobese)":[165,188],"Also":[167],"HOMA-IR":[168],"values":[169],"found":[171],"be":[173,224],"circumferance":[183],"results":[191],"this":[193],"suggest":[195],"that,":[196],"together":[200],"decreased":[203,210],"antioxidative":[204],"defence":[205],"seems":[206],"contribute":[208],"sensitivity":[212],"related":[214],"adiposity":[216],"men,":[221],"hypothesized":[225],"favor":[227],"development":[229],"(Journal":[237],"American":[239],"Science":[240],"2010;":[241],"6(9):604-611).":[242],"(ISSN:":[243],"1545-1003).":[244]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}