{"id":"https://openalex.org/W2183846288","doi":null,"title":"Administration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphoma.","display_name":"Administration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphoma.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2183846288","mag":"2183846288","pmid":"https://pubmed.ncbi.nlm.nih.gov/9408764"},"language":"en","primary_location":{"id":"pmid:9408764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9408764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006810034","display_name":"Ismet Aydogdu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]},{"id":"https://openalex.org/I4210142006","display_name":"Turgut \u00d6zal T\u0131p Merkezi","ror":"https://ror.org/0449k9183","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210142006"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I Aydogdu","raw_affiliation_strings":["Department of Hematology, School of Medicine, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, School of Medicine, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey","institution_ids":["https://openalex.org/I20126385","https://openalex.org/I4210142006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101792372","display_name":"Hakan Ko\u00e7","orcid":"https://orcid.org/0000-0003-1241-1686","observed_orcids":["https://orcid.org/0000-0003-1241-1686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Koc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076735212","display_name":"Osman \u0130lhan","orcid":"https://orcid.org/0000-0003-1665-372X","observed_orcids":["https://orcid.org/0000-0003-1665-372X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Ilhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038588053","display_name":"G\u00fcnhan G\u00fcrman","orcid":"https://orcid.org/0000-0002-1263-8947","observed_orcids":["https://orcid.org/0000-0002-1263-8947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gurman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006552750","display_name":"Hamdi Akan","orcid":"https://orcid.org/0000-0001-8149-1099","observed_orcids":["https://orcid.org/0000-0001-8149-1099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Akan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080776694","display_name":"Meral Beksa\u00e7","orcid":"https://orcid.org/0000-0003-1797-8657","observed_orcids":["https://orcid.org/0000-0003-1797-8657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Beksac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082668714","display_name":"Nah\u0131de Konuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Konuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110642382","display_name":"A. Uysal","orcid":"https://orcid.org/0000-0002-1763-2085","observed_orcids":["https://orcid.org/0000-0002-1763-2085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Uysal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047611762","display_name":"Elif \u00d6zerol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ozerol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"4","first_page":"207","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/intermediate-grade-lymphoma","display_name":"intermediate-grade lymphoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/high-grade-lymphoma","display_name":"high-grade lymphoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mesna","display_name":"mesna","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.7745545506477356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7570103406906128},{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.7102376818656921},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6755083799362183},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6564264297485352},{"id":"https://openalex.org/C2780376820","wikidata":"https://www.wikidata.org/wiki/Q424997","display_name":"Mesna","level":5,"score":0.6439898610115051},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6001432538032532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5617926716804504},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5526868104934692},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5446025133132935},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5191646814346313},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4452546238899231},{"id":"https://openalex.org/C2778476748","wikidata":"https://www.wikidata.org/wiki/Q1138590","display_name":"Non-Hodgkin's lymphoma","level":3,"score":0.44316524267196655},{"id":"https://openalex.org/C2994123057","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Cure rate","level":2,"score":0.4260881543159485},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36594223976135254},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32014259696006775}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015080","descriptor_name":"Mesna","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015080","descriptor_name":"Mesna","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9408764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9408764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologia","raw_type":"Journal Article"},{"id":"mag:2183846288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9408764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1579641819","https://openalex.org/W1841947123","https://openalex.org/W1933973263","https://openalex.org/W1994296072","https://openalex.org/W2000015872","https://openalex.org/W2034238565","https://openalex.org/W2073151455","https://openalex.org/W2093159499","https://openalex.org/W2198883395","https://openalex.org/W2318772898","https://openalex.org/W2405397990","https://openalex.org/W3024436806"],"related_works":["https://openalex.org/W2387942677","https://openalex.org/W3031312040","https://openalex.org/W2003611170","https://openalex.org/W2257495951","https://openalex.org/W2095394060","https://openalex.org/W1989166627","https://openalex.org/W1969597291","https://openalex.org/W303073470","https://openalex.org/W8064160","https://openalex.org/W3029691013"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"more":[3],"effective":[4,113],"and":[5,20,34,41,49,62,78,86,104,114],"less":[6],"toxic":[7],"treatment":[8],"protocols":[9],"have":[10],"been":[11],"developed":[12],"to":[13,30,111],"increase":[14],"the":[15,32,70,95],"cure":[16],"rates":[17],"in":[18,45,69,124],"intermediate":[19,48,127],"high":[21,50,129],"grade":[22,51,130],"non-Hodgkin's":[23],"lymphoma":[24],"(NHL).":[25],"This":[26],"study":[27],"was":[28,92],"undertaken":[29],"investigate":[31],"efficacy":[33],"toxicity":[35,119],"of":[36,76,82],"MINE":[37,108],"(ifosfamide,":[38],"mesna,":[39],"mitoxantrone":[40],"etoposide)":[42],"combination":[43,109],"chemotherapy":[44],"patients":[46,54,91,125],"with":[47,65,126],"NHL.":[52,131],"Twenty-one":[53],"(16":[55],"male,":[56],"5":[57],"female;":[58],"age":[59],"between":[60],"26":[61],"70":[63],"years)":[64],"NHL":[66],"were":[67,84,106],"included":[68],"study.":[71],"An":[72],"overall":[73],"response":[74,80],"rate":[75,81,88],"73%":[77],"complete":[79],"56%":[83],"achieved":[85],"survival":[87],"for":[89],"responding":[90],"80%":[93],"at":[94],"48th":[96],"month.":[97],"Side":[98],"effects":[99],"including":[100],"mild":[101],"myelosuppression,":[102],"nausea/vomiting":[103],"alopecia":[105],"observed.":[107],"seems":[110],"be":[112],"well":[115],"tolerated":[116],"without":[117],"significant":[118],"as":[120],"a":[121],"first-line":[122],"therapy":[123],"or":[128]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}