{"id":"https://openalex.org/W2183770925","doi":null,"title":"mTOR inhibition sensitizes gastric cancer to alkylating chemotherapy in vivo.","display_name":"mTOR inhibition sensitizes gastric cancer to alkylating chemotherapy in vivo.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2183770925","mag":"2183770925","pmid":"https://pubmed.ncbi.nlm.nih.gov/19189667"},"language":"en","primary_location":{"id":"pmid:19189667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050872462","display_name":"Daniel Cejka","orcid":"https://orcid.org/0000-0001-7162-1443","observed_orcids":["https://orcid.org/0000-0001-7162-1443"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Daniel Cejka","raw_affiliation_strings":["Section of Experimental Oncology/Molecular Pharmacology, Department of Clinical Pharmacology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Experimental Oncology/Molecular Pharmacology, Department of Clinical Pharmacology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057141936","display_name":"Matthias Preusser","orcid":"https://orcid.org/0000-0003-3541-2315","observed_orcids":["https://orcid.org/0000-0003-3541-2315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Preusser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004872477","display_name":"Thorsten Fuereder","orcid":"https://orcid.org/0000-0001-5356-6452","observed_orcids":["https://orcid.org/0000-0001-5356-6452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thorsten Fuereder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036486301","display_name":"Wolfgang Sieghart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Sieghart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090118471","display_name":"Johannes M. Werzowa","orcid":"https://orcid.org/0000-0003-2507-1377","observed_orcids":["https://orcid.org/0000-0003-2507-1377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes Werzowa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089908971","display_name":"Sabine Strommer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Strommer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009244604","display_name":"Volker Wacheck","orcid":"https://orcid.org/0000-0003-3962-5932","observed_orcids":["https://orcid.org/0000-0003-3962-5932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volker Wacheck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.568,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82188555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"6A","first_page":"3801","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":1.0},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alkylating-chemotherapy","display_name":"alkylating chemotherapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8519999980926514},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8379999995231628},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7940000295639038},{"id":"https://openalex.org/keywords/scid-mouse-xenograft","display_name":"SCID mouse xenograft","score":0.75},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.9576658010482788},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.7742682695388794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6302356719970703},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5416032075881958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.530996561050415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5110114812850952},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.49991726875305176},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4864339828491211},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47294971346855164},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4642537236213684},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.461783230304718},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.41115519404411316},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29980722069740295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27658310532569885},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2541080713272095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16490957140922546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13679486513137817},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19189667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2183770925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W184148271","https://openalex.org/W1485463834","https://openalex.org/W1545893705","https://openalex.org/W1605422292","https://openalex.org/W1994577610","https://openalex.org/W1996102081","https://openalex.org/W1996552994","https://openalex.org/W1996831788","https://openalex.org/W1999985162","https://openalex.org/W2018022997","https://openalex.org/W2021051229","https://openalex.org/W2026351725","https://openalex.org/W2026569756","https://openalex.org/W2032164885","https://openalex.org/W2034881067","https://openalex.org/W2037136309","https://openalex.org/W2049489582","https://openalex.org/W2062230565","https://openalex.org/W2066317700","https://openalex.org/W2075997152","https://openalex.org/W2084740377","https://openalex.org/W2104381422","https://openalex.org/W2106234889","https://openalex.org/W2109134893","https://openalex.org/W2114787204","https://openalex.org/W2115009664","https://openalex.org/W2120129511","https://openalex.org/W2130348457","https://openalex.org/W2153867442","https://openalex.org/W2153949698","https://openalex.org/W2159789252","https://openalex.org/W2164895949","https://openalex.org/W2167761137","https://openalex.org/W2169992085"],"related_works":["https://openalex.org/W1965700705","https://openalex.org/W1997117033","https://openalex.org/W6980856394","https://openalex.org/W3026926990","https://openalex.org/W2068964160","https://openalex.org/W1969312432","https://openalex.org/W2139478238","https://openalex.org/W2590319013","https://openalex.org/W7117341638","https://openalex.org/W1996102081"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastric":[1],"cancer":[2,12,53,80,230],"is":[3],"a":[4,77,139,148,180,219],"highly":[5],"chemoresistant":[6],"tumor.":[7],"Previous":[8],"studies":[9],"suggest":[10],"that":[11,38],"cells":[13],"can":[14],"be":[15],"sensitized":[16],"to":[17,125,138],"standard":[18],"chemotherapy,":[19],"and":[20,106,127,147,156,206],"especially":[21],"alkylating":[22],"agents,":[23],"by":[24],"inhibition":[25],"of":[26,29,108,158,163,215,222,240],"mammalian":[27],"target":[28],"rapamycin":[30],"(mTOR)":[31],"signaling.":[32],"The":[33,212],"work":[34],"presented":[35],"here":[36],"shows":[37,224],"the":[39,62,161,238],"mTOR":[40],"inhibitor":[41],"everolimus,":[42],"in":[43,51,68,76,142,168,184,207,231,242],"combination":[44,69,162,208,243],"with":[45,59,70,165,179,189,209,218,245],"cyclophosphamide,":[46],"exhibits":[47],"synergistic":[48,169,225],"antitumor":[49,134,176,226],"activity":[50,135,171,177,214,227],"gastric":[52,79,229],"xenografts.":[54],"MATERIALS":[55],"AND":[56],"METHODS:":[57],"Treatment":[58],"everolimus":[60,164,190,216,246],"at":[61,72,195],"minimal":[63],"effective":[64],"dose":[65,75,198,221],"was":[66,136,191],"studied":[67],"cyclophosphamide":[71,128,166,194,223,241],"maximum":[73,196],"tolerated":[74,197],"human":[78],"severe":[81],"combined":[82,217],"immunodeficient":[83],"(SCID)":[84],"mouse":[85],"xenograft":[86],"model.":[87],"Besides":[88],"tumor":[89,122,143,152],"size,":[90],"biomarker":[91],"expression":[92,155],"for":[93],"proliferation":[94,145],"(Ki-67),":[95],"hypoxia":[96],"(HIF-12alpha),":[97],"apoptosis":[98],"(activated":[99],"caspase":[100],"3),":[101],"angiogenesis":[102],"(microvascular":[103],"density,":[104],"MVD)":[105],"levels":[107,157],"circulating":[109],"endothelial":[110],"progenitors":[111],"(CEPs)":[112],"were":[113],"assessed.":[114],"RESULTS:":[115],"Everolimus":[116],"single":[117],"agent":[118],"treatment":[119,129,188],"significantly":[120],"inhibited":[121],"growth":[123],"relative":[124],"control":[126],"(T/C":[130,172],"19%,":[131],"p<0.01).":[132,174],"This":[133,175],"linked":[137],"significant":[140,182,201],"decrease":[141,183],"cell":[144],"(p<0.01)":[146],"trend":[149],"towards":[150],"lower":[151],"MVD,":[153],"HIF-1alpha":[154],"CEPs.":[159],"Notably,":[160],"resulted":[167],"anti-tumor":[170],"9%,":[173],"coincided":[178],"statistically":[181],"MVD":[185],"(p<0.01).":[186],"Whereas":[187],"well":[192],"tolerated,":[193],"(MTD)":[199],"showed":[200],"toxicity":[202,239],"both":[203],"as":[204],"monotherapy":[205],"everolimus.":[210],"CONCLUSION:":[211],"antiangiogenic":[213],"high":[220],"against":[228],"vivo.":[232],"In":[233],"potential":[234],"future":[235],"clinical":[236],"trials,":[237],"regimens":[244],"deserves":[247],"careful":[248],"evaluation.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
