{"id":"https://openalex.org/W2183766824","doi":null,"title":"Glomerular basement membrane anionic charge site changes early in aminonucleoside nephrosis.","display_name":"Glomerular basement membrane anionic charge site changes early in aminonucleoside nephrosis.","publication_year":1986,"publication_date":"1986-11-01","ids":{"openalex":"https://openalex.org/W2183766824","mag":"2183766824","pmid":"https://pubmed.ncbi.nlm.nih.gov/3789094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888254"},"language":"en","primary_location":{"id":"pmid:3789094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3789094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888254/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058086231","display_name":"John D. Mahan","orcid":"https://orcid.org/0000-0001-5175-1339","observed_orcids":["https://orcid.org/0000-0001-5175-1339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Mahan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012774894","display_name":"Susan Sisson-Ross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sisson-Ross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034625587","display_name":"Robert L. Vernier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Vernier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5583,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.87627424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"125","issue":"2","first_page":"393","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerular-basement-membrane","display_name":"glomerular basement membrane","score":0.996999979019165},{"id":"https://openalex.org/keywords/aminonucleoside-nephrosis","display_name":"aminonucleoside nephrosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lamina-rara-externa","display_name":"lamina rara externa","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glomerular-epithelial-cells","display_name":"glomerular epithelial cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7799999713897705},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.890999972820282},{"id":"https://openalex.org/keywords/idiopathic-nephrotic-syndrome","display_name":"idiopathic nephrotic syndrome","score":0.8669999837875366},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.7479069828987122},{"id":"https://openalex.org/C3060791","wikidata":"https://www.wikidata.org/wiki/Q3216737","display_name":"Lamina densa","level":3,"score":0.7178677320480347},{"id":"https://openalex.org/C2781175652","wikidata":"https://www.wikidata.org/wiki/Q6995207","display_name":"Nephrosis","level":2,"score":0.6087433099746704},{"id":"https://openalex.org/C22731427","wikidata":"https://www.wikidata.org/wiki/Q2071346","display_name":"Perlecan","level":4,"score":0.6020159125328064},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5793976187705994},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.577125072479248},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.5735228061676025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5446881055831909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5339310169219971},{"id":"https://openalex.org/C2777747828","wikidata":"https://www.wikidata.org/wiki/Q1323002","display_name":"Minimal change disease","level":5,"score":0.4738750159740448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45971277356147766},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.45426836609840393},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4519793391227722},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.42827892303466797},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3784644901752472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35209473967552185},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.31919020414352417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2642320990562439},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.19237303733825684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13514044880867004},{"id":"https://openalex.org/C2778415529","wikidata":"https://www.wikidata.org/wiki/Q1435223","display_name":"Focal segmental glomerulosclerosis","level":4,"score":0.12660673260688782},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.06949523091316223}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3789094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3789094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1888254","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888254/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:2183766824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3789094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888254","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888254/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W22622405","https://openalex.org/W78586976","https://openalex.org/W120307256","https://openalex.org/W182294170","https://openalex.org/W1210279122","https://openalex.org/W1977795149","https://openalex.org/W1980741458","https://openalex.org/W1993353440","https://openalex.org/W2002983094","https://openalex.org/W2003818367","https://openalex.org/W2003929885","https://openalex.org/W2021937321","https://openalex.org/W2022531406","https://openalex.org/W2035907187","https://openalex.org/W2039817771","https://openalex.org/W2060101571","https://openalex.org/W2069176317","https://openalex.org/W2077400092","https://openalex.org/W2082443082","https://openalex.org/W2088251369","https://openalex.org/W2121375256","https://openalex.org/W2158347476","https://openalex.org/W2326341708","https://openalex.org/W2331591746","https://openalex.org/W2336608216","https://openalex.org/W2396245893","https://openalex.org/W2404294997","https://openalex.org/W2405615845","https://openalex.org/W2411023590","https://openalex.org/W2411348660","https://openalex.org/W2415788628","https://openalex.org/W2417779504","https://openalex.org/W2417983765","https://openalex.org/W2435321033","https://openalex.org/W2465606232","https://openalex.org/W2468458574"],"related_works":["https://openalex.org/W1986054981","https://openalex.org/W3131169581","https://openalex.org/W1993353440","https://openalex.org/W2414619477","https://openalex.org/W16898192","https://openalex.org/W1259211627","https://openalex.org/W2062270064","https://openalex.org/W2003929885","https://openalex.org/W794585228","https://openalex.org/W2038966660"],"abstract_inverted_index":{"Alterations":[0],"of":[1,13,18,47,60,82,153,183,204],"glomerular":[2,137,200,209],"basement":[3],"membrane":[4],"(GBM)":[5],"anionic":[6,189],"(charge":[7],"sites,":[8],"CSs)":[9],"in":[10,15,22,29,53,56,64,89,106,123,127,136,193],"the":[11,30,68,151],"development":[12],"proteinuria":[14],"a":[16,57,86,197],"model":[17],"idiopathic":[19],"nephrotic":[20,26],"syndrome":[21,27],"man":[23],"(puromycin":[24],"aminonucleoside":[25],"[PAN]":[28],"rat)":[31],"were":[32,51],"assessed":[33],"quantitatively":[34],"and":[35,111,145,149,160,195],"sequentially":[36],"early":[37,192],"after":[38,80],"disease":[39],"induction.":[40],"GBM":[41,90,105,122,177,205],"CSs":[42],"(known":[43],"to":[44],"consist":[45],"mainly":[46],"heparan":[48],"sulfate-rich":[49],"proteoglycans)":[50],"stained":[52],"vivo":[54],"and,":[55],"separate":[58],"group":[59],"animals":[61],"by":[62,74,108,125],"an":[63],"vitro":[65,128],"method,":[66],"with":[67,134],"cationic":[69],"marker":[70],"polyethyleneimine":[71],"(PEI)":[72],"studied":[73],"electron":[75],"microscopic":[76],"examination.":[77],"Four":[78],"hours":[79],"administration":[81],"PAN,":[83],"there":[84],"was":[85],"significant":[87,169],"decrease":[88],"lamina":[91],"rara":[92],"externa":[93],"CSs:":[94],"18":[95],"+/-":[96,100,113,117],"0.7":[97],"versus":[98,115],"22.0":[99],"2.2":[101],"per":[102,119],"1000":[103,120],"nm":[104,121],"controls":[107,124],"PEI":[109,126],"injection":[110],"17.2":[112],"2.7":[114],"21.1":[116],"1.6":[118],"staining.":[129],"This":[130],"CS":[131,206],"alteration":[132],"coincided":[133],"changes":[135],"epithelial":[138,201],"cell":[139,202],"morphologic":[140],"characteristics":[141],"(increased":[142],"cytoplasmic":[143],"organelles":[144],"rough":[146],"endoplasmic":[147],"reticulum)":[148],"preceded":[150],"detection":[152],"foot":[154],"process":[155],"broadening":[156],"(at":[157],"24":[158],"hours)":[159],"increased":[161],"urinary":[162],"albuminuria":[163],"(suggested":[164],"at":[165,170],"12-24":[166],"hours,":[167],"statistically":[168],"36-48":[171],"hours).":[172],"These":[173],"results":[174],"suggest":[175],"that":[176],"CS-heparan":[178],"sulfate":[179],"proteoglycan":[180],"alterations":[181],"consisting":[182],"either":[184],"decreased":[185],"number":[186],"and/or":[187],"less":[188],"charge":[190],"occur":[191],"PAN":[194],"support":[196],"role":[198],"for":[199,207],"maintenance":[203],"normal":[208],"function.":[210]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}