{"id":"https://openalex.org/W2183686679","doi":null,"title":"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.","display_name":"Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2183686679","mag":"2183686679","pmid":"https://pubmed.ncbi.nlm.nih.gov/12939402"},"language":"en","primary_location":{"id":"pmid:12939402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12939402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yongqing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongqing Li","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037433877","display_name":"Wei\u2010Hsuan Yu","orcid":"https://orcid.org/0000-0002-1782-3738","observed_orcids":["https://orcid.org/0000-0002-1782-3738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Hsuan Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045619","display_name":"Jian Ren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344141","display_name":"Wen Chen","orcid":"https://orcid.org/0000-0001-5376-3552","observed_orcids":["https://orcid.org/0000-0001-5376-3552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057534797","display_name":"Lei Haley Huang","orcid":"https://orcid.org/0000-0002-4851-4807","observed_orcids":["https://orcid.org/0000-0002-4851-4807","https://orcid.org/0000-0003-1003-7416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017943660","display_name":"Surender M. Kharbanda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Surender Kharbanda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071763026","display_name":"Massimo F. Loda","orcid":"https://orcid.org/0000-0001-9674-8379","observed_orcids":["https://orcid.org/0000-0001-9674-8379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Loda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067054634","display_name":"Donald W. Kufe","orcid":"https://orcid.org/0000-0001-5743-8888","observed_orcids":["https://orcid.org/0000-0001-5743-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Kufe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8167,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.90788625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1","issue":"10","first_page":"765","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.777999997138977},{"id":"https://openalex.org/keywords/gamma-catenin","display_name":"gamma-catenin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.7279999852180481},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6169999837875366},{"id":"https://openalex.org/keywords/nucleolar-targeting","display_name":"nucleolar targeting","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.8627533912658691},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.7619905471801758},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.7295799851417542},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6798741817474365},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.6174252033233643},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6095840930938721},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.5540310144424438},{"id":"https://openalex.org/C2778560701","wikidata":"https://www.wikidata.org/wiki/Q14914188","display_name":"Neuregulin 1","level":3,"score":0.5332028269767761},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.49336186051368713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49015387892723083},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4511796236038208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4402488172054291},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4388572871685028},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2620895504951477},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2617022395133972},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2117711305618286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10229706764221191}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051180","descriptor_name":"Desmoplakins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051185","descriptor_name":"gamma Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12939402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12939402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.916.840","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.916.840","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcr.aacrjournals.org/content/1/10/765.full.pdf","raw_type":"text"},{"id":"mag:2183686679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12939402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877859","display_name":"Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer","funder_award_id":"R01CA097098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1480255729","https://openalex.org/W1491701783","https://openalex.org/W1541668845","https://openalex.org/W1576174931","https://openalex.org/W1606615500","https://openalex.org/W1877472591","https://openalex.org/W1920794749","https://openalex.org/W1963804483","https://openalex.org/W1967647822","https://openalex.org/W1981108516","https://openalex.org/W1986256428","https://openalex.org/W1989589242","https://openalex.org/W1993496373","https://openalex.org/W1994708622","https://openalex.org/W2007121859","https://openalex.org/W2010571201","https://openalex.org/W2016956014","https://openalex.org/W2019182965","https://openalex.org/W2023761151","https://openalex.org/W2035538867","https://openalex.org/W2040142253","https://openalex.org/W2046318163","https://openalex.org/W2048653746","https://openalex.org/W2053029064","https://openalex.org/W2055099935","https://openalex.org/W2060358477","https://openalex.org/W2071416872","https://openalex.org/W2074605890","https://openalex.org/W2076370383","https://openalex.org/W2077374035","https://openalex.org/W2086725260","https://openalex.org/W2106681630","https://openalex.org/W2108435741","https://openalex.org/W2111004422","https://openalex.org/W2111021104","https://openalex.org/W2111941775","https://openalex.org/W2120754979","https://openalex.org/W2122788299","https://openalex.org/W2123206362","https://openalex.org/W2127085660","https://openalex.org/W2141823136","https://openalex.org/W2143651667","https://openalex.org/W2171854519","https://openalex.org/W2333971726","https://openalex.org/W2467073646","https://openalex.org/W4292429126","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W7095367014","https://openalex.org/W2327378759","https://openalex.org/W2318318653","https://openalex.org/W2016956014","https://openalex.org/W2102850350","https://openalex.org/W3120946930","https://openalex.org/W2076370383","https://openalex.org/W2034451570","https://openalex.org/W4235476737","https://openalex.org/W1562232594"],"abstract_inverted_index":{"The":[0,45],"DF3/MUC1":[1],"transmembrane":[2],"oncoprotein":[3],"is":[4,51,82],"aberrantly":[5],"overexpressed":[6],"in":[7,28,78,93,119,125,136],"most":[8],"human":[9,29,120],"breast":[10,30,121],"carcinomas":[11,122],"and":[12,33,62,64,104,117,141],"interacts":[13],"with":[14,26,36,108],"the":[15,40,48,54,67,71,94],"Wnt":[16,142],"effector":[17],"gamma-catenin.":[18,105,154],"Here,":[19],"we":[20,111],"demonstrate":[21,132],"that":[22,34,56,133],"MUC1":[23,61,85,95,103,116,134],"associates":[24],"constitutively":[25],"ErbB2":[27,140],"cancer":[31],"cells":[32],"treatment":[35],"heregulin/neuregulin-1":[37],"(HRG)":[38],"increases":[39],"formation":[41],"of":[42,47,60,66,76,89,102,115,153],"MUC1-ErbB2":[43,49],"complexes.":[44],"importance":[46],"interaction":[50],"supported":[52],"by":[53,144],"demonstration":[55],"HRG":[57,81],"induces":[58],"binding":[59],"gamma-catenin":[63,77,118],"targeting":[65,152],"MUC1-gamma-catenin":[68],"complex":[69],"to":[70,80],"nucleolus.":[72],"Significantly,":[73],"nucleolar":[74,100,113,151],"localization":[75,101,114],"response":[79],"dependent":[83],"on":[84],"expression.":[86],"Moreover,":[87],"mutation":[88],"a":[90,147],"RRK":[91],"motif":[92],"cytoplasmic":[96],"domain":[97],"abrogates":[98],"HRG-induced":[99,150],"In":[106],"concert":[107],"these":[109],"results,":[110],"show":[112],"but":[123],"not":[124],"normal":[126],"mammary":[127],"ductal":[128],"epithelium.":[129],"These":[130],"findings":[131],"functions":[135],"cross":[137],"talk":[138],"between":[139],"pathways":[143],"acting":[145],"as":[146],"shuttle":[148],"for":[149]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
