{"id":"https://openalex.org/W2183634673","doi":null,"title":"Kidney development: roles of Sprouty, Wnt2b and type XVIII collagen in the ureteric bud morphogenesis","display_name":"Kidney development: roles of Sprouty, Wnt2b and type XVIII collagen in the ureteric bud morphogenesis","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2183634673","mag":"2183634673"},"language":"en","primary_location":{"id":"mag:2183634673","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514269918.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089999132","display_name":"Shaobing Zhang","orcid":"https://orcid.org/0000-0001-7532-6994","observed_orcids":["https://orcid.org/0000-0001-7532-6994"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shaobing Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7532-6994","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089999132"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ureteric-bud","display_name":"ureteric bud","score":0.8429999947547913},{"id":"https://openalex.org/keywords/branching-morphogenesis","display_name":"branching morphogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sprouty","display_name":"Sprouty","score":0.8190000057220459},{"id":"https://openalex.org/keywords/spry2","display_name":"SPRY2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/wnt2b","display_name":"WNT2B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/type-xviii-collagen","display_name":"type XVIII collagen","score":0.8830000162124634},{"id":"https://openalex.org/keywords/metanephros","display_name":"metanephros","score":0.5609999895095825},{"id":"https://openalex.org/keywords/glomerulus","display_name":"glomeruli","score":0.5080000162124634},{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-organogenesis","display_name":"lung organogenesis","score":0.718999981880188},{"id":"https://openalex.org/keywords/cystic-kidney-disease","display_name":"cystic kidney disease","score":0.6010000109672546},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C130010870","wikidata":"https://www.wikidata.org/wiki/Q2500532","display_name":"Ureteric bud","level":5,"score":0.9188472032546997},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.8902419209480286},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.7634497880935669},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.7373759746551514},{"id":"https://openalex.org/C146759223","wikidata":"https://www.wikidata.org/wiki/Q17927902","display_name":"FGF10","level":4,"score":0.6559345722198486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6081178188323975},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6023862361907959},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5981038212776184},{"id":"https://openalex.org/C30503417","wikidata":"https://www.wikidata.org/wiki/Q958938","display_name":"Organogenesis","level":3,"score":0.5361316800117493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5265039801597595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5169495940208435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.507171630859375},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.4455582797527313},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.20282208919525146},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1838172972202301},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15412327647209167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14861297607421875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12246862053871155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09262529015541077}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183634673","doi":null,"is_oa":false,"landing_page_url":"http://jultika.oulu.fi/files/isbn9514269918.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W100176357","https://openalex.org/W189173739","https://openalex.org/W219550331","https://openalex.org/W1242685221","https://openalex.org/W1484163259","https://openalex.org/W1489683592","https://openalex.org/W1494249446","https://openalex.org/W1495114372","https://openalex.org/W1542932778","https://openalex.org/W1543347748","https://openalex.org/W1555070335","https://openalex.org/W1560267422","https://openalex.org/W1574990684","https://openalex.org/W1575984269","https://openalex.org/W1592656278","https://openalex.org/W1596549154","https://openalex.org/W1630290269","https://openalex.org/W1648692159","https://openalex.org/W1768274470","https://openalex.org/W1832267083","https://openalex.org/W1849230910","https://openalex.org/W1854803455","https://openalex.org/W1873268238","https://openalex.org/W1922337323","https://openalex.org/W1923107379","https://openalex.org/W1950995033","https://openalex.org/W1961962216","https://openalex.org/W1963272169","https://openalex.org/W1965785388","https://openalex.org/W1969295674","https://openalex.org/W1969910714","https://openalex.org/W1970750249","https://openalex.org/W1971238657","https://openalex.org/W1971482506","https://openalex.org/W1971689970","https://openalex.org/W1972838071","https://openalex.org/W1977376400","https://openalex.org/W1978596841","https://openalex.org/W1983228128","https://openalex.org/W1984294894","https://openalex.org/W1985360296","https://openalex.org/W1987566228","https://openalex.org/W1988190121","https://openalex.org/W1988757615","https://openalex.org/W1989244336","https://openalex.org/W1989960601","https://openalex.org/W1991598333","https://openalex.org/W1994866548","https://openalex.org/W1994926193","https://openalex.org/W1997170970","https://openalex.org/W2001074180","https://openalex.org/W2001475400","https://openalex.org/W2005294501","https://openalex.org/W2007388637","https://openalex.org/W2007413389","https://openalex.org/W2008434851","https://openalex.org/W2008735905","https://openalex.org/W2011028864","https://openalex.org/W2011237068","https://openalex.org/W2017429814","https://openalex.org/W2018542248","https://openalex.org/W2019890022","https://openalex.org/W2019890950","https://openalex.org/W2019951086","https://openalex.org/W2021956062","https://openalex.org/W2022422012","https://openalex.org/W2022527563","https://openalex.org/W2023324175","https://openalex.org/W2024215958","https://openalex.org/W2024593057","https://openalex.org/W2025532009","https://openalex.org/W2026213059","https://openalex.org/W2027322371","https://openalex.org/W2027582069","https://openalex.org/W2028093783","https://openalex.org/W2029435921","https://openalex.org/W2031112866","https://openalex.org/W2032212808","https://openalex.org/W2036944081","https://openalex.org/W2037306751","https://openalex.org/W2039309643","https://openalex.org/W2039431980","https://openalex.org/W2041116703","https://openalex.org/W2043840480","https://openalex.org/W2044069347","https://openalex.org/W2046841536","https://openalex.org/W2047304258","https://openalex.org/W2047727235","https://openalex.org/W2048675800","https://openalex.org/W2048837917","https://openalex.org/W2051788298","https://openalex.org/W2053989269","https://openalex.org/W2058527255","https://openalex.org/W2059908281","https://openalex.org/W2060029591","https://openalex.org/W2061628657","https://openalex.org/W2062054469","https://openalex.org/W2065295496","https://openalex.org/W2065338484","https://openalex.org/W2066111244","https://openalex.org/W2066479550","https://openalex.org/W2067283439","https://openalex.org/W2067488666","https://openalex.org/W2071786396","https://openalex.org/W2073234446","https://openalex.org/W2073724437","https://openalex.org/W2074307099","https://openalex.org/W2076894266","https://openalex.org/W2078536996","https://openalex.org/W2080184926","https://openalex.org/W2080372560","https://openalex.org/W2080620426","https://openalex.org/W2081285491","https://openalex.org/W2082496437","https://openalex.org/W2082773871","https://openalex.org/W2082968098","https://openalex.org/W2083504420","https://openalex.org/W2086200882","https://openalex.org/W2086574903","https://openalex.org/W2087249833","https://openalex.org/W2089104116","https://openalex.org/W2092648069","https://openalex.org/W2093351885","https://openalex.org/W2096056021","https://openalex.org/W2099543104","https://openalex.org/W2102345821","https://openalex.org/W2107044385","https://openalex.org/W2108290796","https://openalex.org/W2108489580","https://openalex.org/W2110042849","https://openalex.org/W2110480099","https://openalex.org/W2111334408","https://openalex.org/W2114011703","https://openalex.org/W2114115521","https://openalex.org/W2114245705","https://openalex.org/W2115125970","https://openalex.org/W2116996386","https://openalex.org/W2119358932","https://openalex.org/W2120045068","https://openalex.org/W2122892477","https://openalex.org/W2124415162","https://openalex.org/W2124852687","https://openalex.org/W2125921102","https://openalex.org/W2129448282","https://openalex.org/W2131798870","https://openalex.org/W2131946517","https://openalex.org/W2138178479","https://openalex.org/W2139470337","https://openalex.org/W2140099557","https://openalex.org/W2143416290","https://openalex.org/W2149388963","https://openalex.org/W2149854941","https://openalex.org/W2151076343","https://openalex.org/W2152207415","https://openalex.org/W2152509610","https://openalex.org/W2153800130","https://openalex.org/W2154294808","https://openalex.org/W2156221138","https://openalex.org/W2157666800","https://openalex.org/W2159100602","https://openalex.org/W2159777824","https://openalex.org/W2161968188","https://openalex.org/W2164101293","https://openalex.org/W2164599679","https://openalex.org/W2165061154","https://openalex.org/W2168281987","https://openalex.org/W2254959871","https://openalex.org/W2335471307","https://openalex.org/W2344364145","https://openalex.org/W2401683652","https://openalex.org/W2403825896","https://openalex.org/W2417182197","https://openalex.org/W2417777665","https://openalex.org/W3102865740","https://openalex.org/W7095734969"],"related_works":["https://openalex.org/W2065301300","https://openalex.org/W2894957469","https://openalex.org/W2029283176","https://openalex.org/W2035951460","https://openalex.org/W1963968195","https://openalex.org/W2012587181","https://openalex.org/W2081422914","https://openalex.org/W3047331493","https://openalex.org/W2139336984","https://openalex.org/W2014275971"],"abstract_inverted_index":{"The":[0],"mammalian":[1],"metanephric":[2],"kidney":[3,78,93,103,139,209,234,281,299,333,380],"develops":[4],"through":[5],"ureteric":[6,67,75,110,167,251,291,309,368,405,414,450],"bud":[7,111,252,259,369,451],"branching":[8,128,168,255,310,349,452],"morphogenesis":[9],"and":[10,13,18,33,55,69,71,80,124,131,152,158,198,254,276,295,320,334,355,370,384,396,419,438,446],"tubule":[11],"formation":[12,445],"involves":[14],"secreted":[15,222],"inductive":[16],"signals":[17],"possibly":[19],"their":[20],"antagonists":[21,30],"to":[22,42,108,119,141,154,186,194,238,284,381],"regulate":[23],"the":[24,34,47,50,66,74,77,81,90,102,109,142,170,203,218,233,239,244,287,345,359,404,424,430,447,454],"process.":[25],"Sprouty":[26],"(spry)":[27],"genes":[28,294],"encode":[29],"of":[31,46,52,121,150,169,196,217,221,246,286,289,297,308,328,352,367,408,426,449],"FGFs":[32,165],"EGF":[35],"signalling":[36,149,180,249,303],"pathways.":[37],"To":[38],"get":[39],"an":[40],"insight":[41],"potential":[43],"developmental":[44,87],"roles":[45,88,434],"spry":[48],"genes,":[49],"expression":[51,107,117,191,288,342,357,376,395,425],"spry1,":[53],"2":[54],"4":[56,72],"was":[57,97,129,133,261,337,362,385],"analyzed":[58],"in":[59,65,73,92,99,101,136,156,181,188,228,256,311,324,332,347,350,358,390,403,423,442,453],"developing":[60],"kidney.":[61,183,456],"Spry1":[62],"is":[63,206,212,230,236,304,316],"expressed":[64],"bud,":[68,76],"spry2":[70],"mesenchyme":[79,282,418],"nephrons":[82],"deriving":[83],"from":[84,379],"it":[85],"suggesting":[86,174],"for":[89,208,306,435],"sprys":[91],"development.":[94,210,300],"Spry":[95],"function":[96,227,412],"addressed":[98],"vivo":[100],"by":[104,387,397],"targeting":[105],"hspry2":[106,190],"with":[112,263,269,279,344,416,421],"a":[113,137,213,270,317,388],"Pax2":[114],"promoter.":[115],"Hspry2":[116],"led":[118,283],"development":[120,415],"small,":[122],"ectopic":[123,164,398],"cystic":[125],"kidneys.":[126],"Ureter":[127],"reduced":[130],"there":[132],"less":[134],"glomeruli":[135],"smaller":[138],"compared":[140],"wild":[143],"type":[144,329,373,383,409,439],"controls.":[145],"Spry2":[146],"may":[147,177,321],"antagonize":[148,178],"FGF2":[151],"lead":[153,193],"changes":[155,187],"FGFR1":[157],"FGFR3":[159],"expression.":[160],"In":[161,184,232,365],"organ":[162],"culture":[163],"restored":[166],"hSpry2":[171,176],"transgenic":[172],"kidneys":[173],"that":[175,202,260],"FGF":[179],"embryonic":[182,455],"addition":[185],"FGFs,":[189],"also":[192],"downregulation":[195],"GDNF":[197],"BMP4.":[199],"We":[200],"conclude":[201],"Sprouty-FGFs-FGFR":[204],"signaling":[205],"important":[207],"Wnt2b":[211,235,248,264,302,437],"recently":[214],"identified":[215],"member":[216],"Wnt":[219,272,325],"family":[220],"growth":[223,253],"factors,":[224],"but":[225],"its":[226,356],"organogenesis":[229,336],"unknown.":[231],"localized":[237],"perinephric":[240],"mesenchymal":[241],"cells":[242,266],"at":[243],"initiation":[245],"organogenesis.":[247],"supported":[250],"vitro.":[257,312],"Ureteric":[258],"co-cultured":[262],"expressive":[265],"or":[267],"incubated":[268],"known":[271],"pathway":[273],"regulator":[274],"lithium,":[275],"then":[277],"recombined":[278],"isolated":[280],"recovery":[285],"some":[290],"epithelial":[292,348,360,391],"marker":[293],"reconstitution":[296],"early":[298],"Hence,":[301],"critical":[305,433],"induction":[307],"Type":[313,339],"XVIII":[314,330,340,374,410,440],"collagen":[315,331,341,375,411,441],"matrix":[318],"molecule":[319],"be":[322],"involved":[323],"signalling.":[326],"Roles":[327],"lung":[335,371,382,399,417],"analysed.":[338],"correlated":[343],"differences":[346],"both":[351],"these":[353],"organs":[354],"tissue":[361],"mutually":[363],"exclusive.":[364],"recombinants":[366],"mesenchyme,":[372],"pattern":[377,444],"shifted":[378],"accompanied":[386],"shift":[389],"Sonic":[392],"Hedgehog":[393],"(Shh)":[394],"Surfactant":[400],"Protein":[401],"C":[402],"bud.":[406],"Blocking":[407],"prevented":[413],"associated":[420],"reduction":[422],"Wnt2.":[427],"Taken":[428],"together,":[429],"findings":[431],"suggest":[432],"Sprouty2,":[436],"controlling":[443],"mode":[448]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}