{"id":"https://openalex.org/W2183592136","doi":null,"title":"Development of an automated identification system for nanocrystal encoded microspheres in flow cytometry.","display_name":"Development of an automated identification system for nanocrystal encoded microspheres in flow cytometry.","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2183592136","mag":"2183592136"},"language":"en","primary_location":{"id":"pmh:oai:dspace.lib.cranfield.ac.uk:1826/4526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1826/4526","pdf_url":"http://hdl.handle.net/1826/4526","source":{"id":"https://openalex.org/S4306401778","display_name":"CERES (Cranfield University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82284825","host_organization_name":"Cranfield University","host_organization_lineage":["https://openalex.org/I82284825"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1826/4526","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019124018","display_name":"Clair Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Clair Gallagher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019124018"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.19619999825954437,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9049999713897705},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":1.0},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.7789999842643738},{"id":"https://openalex.org/keywords/haplotype-construction","display_name":"haplotype construction","score":0.6100000143051147},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7328155636787415},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.659593403339386},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6003229022026062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5920621156692505},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.5160388946533203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49684932827949524},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4661508798599243},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.4563830494880676},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4170018434524536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32594114542007446},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24754270911216736},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.21562853455543518}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.lib.cranfield.ac.uk:1826/4526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1826/4526","pdf_url":"http://hdl.handle.net/1826/4526","source":{"id":"https://openalex.org/S4306401778","display_name":"CERES (Cranfield University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82284825","host_organization_name":"Cranfield University","host_organization_lineage":["https://openalex.org/I82284825"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},{"id":"pmh:hdl:10068/967849","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/967849","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:2183592136","doi":null,"is_oa":false,"landing_page_url":"https://dspace.lib.cranfield.ac.uk/bitstream/1826/4526/1/Clair_Gallagher_thesis_2009.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.lib.cranfield.ac.uk:1826/4526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1826/4526","pdf_url":"http://hdl.handle.net/1826/4526","source":{"id":"https://openalex.org/S4306401778","display_name":"CERES (Cranfield University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82284825","host_organization_name":"Cranfield University","host_organization_lineage":["https://openalex.org/I82284825"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320343","display_name":"Cranfield University","ror":"https://ror.org/05cncd958"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2183592136.pdf","grobid_xml":"https://content.openalex.org/works/W2183592136.grobid-xml"},"referenced_works_count":234,"referenced_works":["https://openalex.org/W74176757","https://openalex.org/W107671624","https://openalex.org/W116672207","https://openalex.org/W204625421","https://openalex.org/W578750287","https://openalex.org/W596330082","https://openalex.org/W601414050","https://openalex.org/W1488424161","https://openalex.org/W1499460075","https://openalex.org/W1561712812","https://openalex.org/W1565238839","https://openalex.org/W1577577364","https://openalex.org/W1583476286","https://openalex.org/W1585635925","https://openalex.org/W1665569364","https://openalex.org/W1827118626","https://openalex.org/W1931843124","https://openalex.org/W1963913631","https://openalex.org/W1964901903","https://openalex.org/W1965265115","https://openalex.org/W1966799726","https://openalex.org/W1966870057","https://openalex.org/W1967680738","https://openalex.org/W1968106738","https://openalex.org/W1968524845","https://openalex.org/W1970104527","https://openalex.org/W1970592466","https://openalex.org/W1971564640","https://openalex.org/W1971579526","https://openalex.org/W1974818185","https://openalex.org/W1976625167","https://openalex.org/W1977677127","https://openalex.org/W1977929904","https://openalex.org/W1978000554","https://openalex.org/W1978062520","https://openalex.org/W1978123206","https://openalex.org/W1980066896","https://openalex.org/W1980397722","https://openalex.org/W1980437308","https://openalex.org/W1980771135","https://openalex.org/W1982335109","https://openalex.org/W1982452287","https://openalex.org/W1985932625","https://openalex.org/W1986484239","https://openalex.org/W1988220558","https://openalex.org/W1988613836","https://openalex.org/W1990393128","https://openalex.org/W1991770775","https://openalex.org/W1992976781","https://openalex.org/W1993850231","https://openalex.org/W1994256100","https://openalex.org/W1995089313","https://openalex.org/W1995646241","https://openalex.org/W1995932433","https://openalex.org/W1996145998","https://openalex.org/W1996148311","https://openalex.org/W1999138082","https://openalex.org/W2000118469","https://openalex.org/W2000141884","https://openalex.org/W2000626804","https://openalex.org/W2003728867","https://openalex.org/W2004828919","https://openalex.org/W2007902064","https://openalex.org/W2008420760","https://openalex.org/W2008901624","https://openalex.org/W2009095852","https://openalex.org/W2009288870","https://openalex.org/W2010363122","https://openalex.org/W2010899064","https://openalex.org/W2011823981","https://openalex.org/W2011828065","https://openalex.org/W2013376909","https://openalex.org/W2015124841","https://openalex.org/W2015408724","https://openalex.org/W2017350973","https://openalex.org/W2018144904","https://openalex.org/W2018255407","https://openalex.org/W2021225519","https://openalex.org/W2022821656","https://openalex.org/W2024992738","https://openalex.org/W2026652423","https://openalex.org/W2031134755","https://openalex.org/W2032413102","https://openalex.org/W2032625254","https://openalex.org/W2032663425","https://openalex.org/W2033361502","https://openalex.org/W2035596628","https://openalex.org/W2038805193","https://openalex.org/W2039146500","https://openalex.org/W2039523879","https://openalex.org/W2040324692","https://openalex.org/W2043446148","https://openalex.org/W2044999997","https://openalex.org/W2045841831","https://openalex.org/W2046419236","https://openalex.org/W2047500476","https://openalex.org/W2047896758","https://openalex.org/W2048150555","https://openalex.org/W2048309218","https://openalex.org/W2048755332","https://openalex.org/W2050082711","https://openalex.org/W2050486233","https://openalex.org/W2051040739","https://openalex.org/W2051142960","https://openalex.org/W2051362946","https://openalex.org/W2051850537","https://openalex.org/W2052383391","https://openalex.org/W2052738825","https://openalex.org/W2054540091","https://openalex.org/W2054563163","https://openalex.org/W2055528600","https://openalex.org/W2059281148","https://openalex.org/W2060763480","https://openalex.org/W2060825517","https://openalex.org/W2063318299","https://openalex.org/W2064218103","https://openalex.org/W2064334597","https://openalex.org/W2066508837","https://openalex.org/W2068151965","https://openalex.org/W2069460691","https://openalex.org/W2070361536","https://openalex.org/W2070661651","https://openalex.org/W2072514327","https://openalex.org/W2076122324","https://openalex.org/W2078224445","https://openalex.org/W2078530466","https://openalex.org/W2079327859","https://openalex.org/W2082142998","https://openalex.org/W2082454728","https://openalex.org/W2082458560","https://openalex.org/W2082591763","https://openalex.org/W2082736281","https://openalex.org/W2082863489","https://openalex.org/W2084507708","https://openalex.org/W2086421549","https://openalex.org/W2086926886","https://openalex.org/W2088244443","https://openalex.org/W2089646842","https://openalex.org/W2090543425","https://openalex.org/W2090788051","https://openalex.org/W2093245824","https://openalex.org/W2094437628","https://openalex.org/W2095224796","https://openalex.org/W2096298665","https://openalex.org/W2096412974","https://openalex.org/W2097349182","https://openalex.org/W2098771161","https://openalex.org/W2100556177","https://openalex.org/W2101749263","https://openalex.org/W2103028520","https://openalex.org/W2103905510","https://openalex.org/W2104434844","https://openalex.org/W2108244474","https://openalex.org/W2108514550","https://openalex.org/W2109257070","https://openalex.org/W2109347434","https://openalex.org/W2109372707","https://openalex.org/W2110121134","https://openalex.org/W2111513196","https://openalex.org/W2111624436","https://openalex.org/W2112874424","https://openalex.org/W2114272184","https://openalex.org/W2115927569","https://openalex.org/W2116047160","https://openalex.org/W2116647508","https://openalex.org/W2116871245","https://openalex.org/W2116908124","https://openalex.org/W2117240964","https://openalex.org/W2118675686","https://openalex.org/W2119166302","https://openalex.org/W2120085910","https://openalex.org/W2120865268","https://openalex.org/W2121495845","https://openalex.org/W2122139577","https://openalex.org/W2123340910","https://openalex.org/W2125887220","https://openalex.org/W2128692282","https://openalex.org/W2129559300","https://openalex.org/W2129815183","https://openalex.org/W2131145551","https://openalex.org/W2133364208","https://openalex.org/W2133382058","https://openalex.org/W2134968568","https://openalex.org/W2137089963","https://openalex.org/W2137167287","https://openalex.org/W2138120340","https://openalex.org/W2140997600","https://openalex.org/W2142400988","https://openalex.org/W2142448093","https://openalex.org/W2142791452","https://openalex.org/W2143238378","https://openalex.org/W2143645153","https://openalex.org/W2145825014","https://openalex.org/W2147790969","https://openalex.org/W2147996514","https://openalex.org/W2149138815","https://openalex.org/W2149250249","https://openalex.org/W2152626773","https://openalex.org/W2153356008","https://openalex.org/W2153637263","https://openalex.org/W2153871811","https://openalex.org/W2155635136","https://openalex.org/W2158591460","https://openalex.org/W2158602565","https://openalex.org/W2158925425","https://openalex.org/W2159181493","https://openalex.org/W2160011392","https://openalex.org/W2160194872","https://openalex.org/W2160938004","https://openalex.org/W2162530578","https://openalex.org/W2162584616","https://openalex.org/W2162615739","https://openalex.org/W2163062162","https://openalex.org/W2163216014","https://openalex.org/W2164095252","https://openalex.org/W2164704569","https://openalex.org/W2165269474","https://openalex.org/W2165287072","https://openalex.org/W2165937662","https://openalex.org/W2166025401","https://openalex.org/W2168629206","https://openalex.org/W2168744717","https://openalex.org/W2278361927","https://openalex.org/W2328547481","https://openalex.org/W2332426798","https://openalex.org/W2397951409","https://openalex.org/W2407236892","https://openalex.org/W2414297905","https://openalex.org/W2418952719","https://openalex.org/W3145924874","https://openalex.org/W3155045811","https://openalex.org/W3196576386","https://openalex.org/W3204728089","https://openalex.org/W4297632218"],"related_works":["https://openalex.org/W1995089313","https://openalex.org/W2050897329","https://openalex.org/W1756257127","https://openalex.org/W2120512069","https://openalex.org/W1972590709","https://openalex.org/W2133766236","https://openalex.org/W2004717473","https://openalex.org/W2072429891","https://openalex.org/W2409733948","https://openalex.org/W1987013357"],"abstract_inverted_index":{"Aim:":[0],"This":[1,359],"work":[2,42,360],"sets":[3,25,243,294],"out":[4],"to":[5,26,44,61,69,94,158,199,244,267,330,368,372],"use":[6],"haplotype-based":[7],"tagSNP":[8,89,186],"selection":[9,90,115,187],"and":[10,22,38,60,88,103,114,120,128,133,149,173,183,212,228,247,256,298,303,317],"a":[11,46,165,274],"systematic":[12],"in":[13,106],"silico":[14,107,280],"analysis":[15,108,281],"for":[16,55,73,81,111,124,138,180,223,233,249,286,319,341,364,385],"design":[17],"of":[18,48,57,65,116,153,194,207,252,261,289,306,325,343,356],"multiplex-compatible":[19],"PCR":[20,53,127,135,146,230,242,293,328],"primer":[21,119,139,234],"SAT":[23,129],"probe":[24,121,167,276],"capture":[27,95],"maximum":[28,96,309],"variation":[29,97,311],"with":[30,201],"minimum":[31],"tests":[32],"across":[33,98,188,218,312],"candidate":[34,99,189,313],"genes":[35,100,220,314],"IGF1,":[36,101,315],"IGFBP1":[37,102,316],"IGFBP3.":[39,104],"Additionally,":[40],"the":[41,63,192,339,354,362,373],"aims":[43],"develop":[45],"number":[47,193],"robust,":[49],"high-efficiency,":[50],"high-specificity":[51,118],"multiplex":[52,126,145,224,241,292,327,345],"constructs":[54,329],"amplification":[56,251,305],"these":[58,66,326],"targets":[59,196],"demonstrate":[62],"applicability":[64,152,260,324],"target":[67,156,219,264],"types":[68],"suspension":[70,159,268,331,346],"array":[71],"genotyping":[72,161,270,333,348,379],"non-insulin-dependant":[74],"diabetes":[75],"mellitus":[76],"association":[77,366],"facilitation.":[78],"Methods:":[79],"Haplotypes":[80],"predominantly":[82],"European":[83,320],"Caucasian":[84,321],"populations":[85],"were":[86,221],"constructed":[87,246],"performed":[91,110,137,211,232],"using":[92,164,169,273,350],"Haploview":[93,177],"Extensive":[105,205],"was":[109,136,162,178,210,231,271],"design,":[112],"evaluation":[113,206],"robust":[117,291],"pairs,":[122],"suitable":[123],"downstream":[125],"analysis.":[130,225],"Singleplex":[131,226],"endpoint":[132],"real-time":[134,229],"pair":[140,168,235],"profile":[141,236],"determination":[142,237],"which":[143,238,300,381],"informed":[144],"set":[147],"construction":[148,182],"optimisation.":[150],"The":[151,259,323],"this":[154,262,357],"complex":[155,263],"type":[157,265],"array-based":[160,269,332,347],"investigated":[163],"model":[166,275],"both":[170],"quantum":[171],"dot-encoded":[172],"fluorophore-encoded":[174],"microspheres.":[175],"Results:":[176],"used":[179],"haplotype":[181],"linkage":[184],"disequilibriumbased":[185],"genes,":[190],"reducing":[191],"SNP":[195],"from":[197],"292":[198],"32":[200],"minimal":[202],"information":[203],"loss.":[204],"potential":[208,363],"tagSNPs":[209],"29":[213,216],"SNPs,":[214],"representing":[215],"bins":[217],"designed":[222,352],"end-point":[227],"allowed":[239],"four":[240,290],"be":[245],"optimised":[248],"simultaneous":[250],"14,":[253],"six,":[254],"five":[255],"two":[257],"targets.":[258],"(14-plex)":[266],"demonstrated":[272],"pair.":[277],"Conclusion:":[278],"In":[279],"techniques":[282],"have":[283],"been":[284,335],"applied":[285],"successful":[287],"development":[288,342],"(14-plex,":[295],"6-plex,":[296],"5-plex":[297],"2-plex)":[299],"display":[301],"high-efficiency":[302],"target-specific":[304],"tagSNPs,":[307],"capturing":[308],"assaycompatible":[310],"IGFBP3":[318],"populations.":[322],"has":[334],"demonstrated,":[336],"thus":[337],"paving":[338],"way":[340],"large":[344],"assays":[349],"probes":[351],"during":[353],"course":[355],"work.":[358],"offers":[361],"comprehensive":[365],"analyses":[367],"become":[369],"more":[370],"accessible":[371],"wider-scientific":[374],"community":[375],"by":[376],"facilitating":[377],"reduced":[378],"burdens":[380],"allow":[382],"increased":[383],"accessibility":[384],"powerful":[386],"association.":[387]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
