{"id":"https://openalex.org/W2183556090","doi":null,"title":"Free Radical Activity and Antioxidant Defense Mechanisms in Patients with Hypothyroidism","display_name":"Free Radical Activity and Antioxidant Defense Mechanisms in Patients with Hypothyroidism","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2183556090","mag":"2183556090"},"language":"en","primary_location":{"id":"mag:2183556090","doi":null,"is_oa":false,"landing_page_url":"https://www.fabrizioangelini.it/wp-content/uploads/2011/09/2009_01_25-Stress-Ossidativo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035204704","display_name":"Palanisamy Pasupathi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Palanisamy Pasupathi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091763210","display_name":"R. Cecily Rosemary Latha","orcid":"https://orcid.org/0009-0008-1721-3754","observed_orcids":["https://orcid.org/0009-0008-1721-3754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Latha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1955,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.59353147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8759999871253967},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.9850000143051147},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.5630000233650208},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.925000011920929},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.9139999747276306},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.996999979019165},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.8803615570068359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7968016862869263},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7761974334716797},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.7701561450958252},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.5989746451377869},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5633043050765991},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.558849036693573},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.48707273602485657},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4866638779640198},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.48199573159217834},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.45903846621513367},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4500657320022583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40142977237701416},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3949650526046753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37941858172416687},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22127574682235718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16789108514785767},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183556090","doi":null,"is_oa":false,"landing_page_url":"https://www.fabrizioangelini.it/wp-content/uploads/2011/09/2009_01_25-Stress-Ossidativo.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1569629748","https://openalex.org/W1581414347","https://openalex.org/W1599342152","https://openalex.org/W1734082729","https://openalex.org/W1965771001","https://openalex.org/W1967487924","https://openalex.org/W1979759777","https://openalex.org/W1982732451","https://openalex.org/W1982995306","https://openalex.org/W2001499226","https://openalex.org/W2006370393","https://openalex.org/W2009399687","https://openalex.org/W2025795822","https://openalex.org/W2051289988","https://openalex.org/W2060194897","https://openalex.org/W2060930755","https://openalex.org/W2072727557","https://openalex.org/W2075883978","https://openalex.org/W2088826552","https://openalex.org/W2096795975","https://openalex.org/W2107116656","https://openalex.org/W2112181382","https://openalex.org/W2114158288","https://openalex.org/W2146832801","https://openalex.org/W2164554101"],"related_works":["https://openalex.org/W2056580632","https://openalex.org/W4414398322","https://openalex.org/W2476703993","https://openalex.org/W1994774717","https://openalex.org/W4360795243","https://openalex.org/W2070314465","https://openalex.org/W4416691514","https://openalex.org/W3148985225","https://openalex.org/W1979759777","https://openalex.org/W7009444805"],"abstract_inverted_index":{"Free":[0],"radical-mediated":[1],"oxidative":[2],"stress":[3],"has":[4],"been":[5],"implicated":[6],"in":[7,15,29,114,121,142,163,167,191,195],"the":[8,70,125,128,171,203],"etiopathogenesis":[9],"of":[10,37,52,75,130,153,173],"several":[11],"autoimmune":[12],"disorders.":[13],"Hypothyroidism":[14],"humans":[16],"is":[17],"widely":[18],"believed":[19],"to":[20,41,147],"impair":[21],"health.":[22],"The":[23,48,107,150],"biochemical":[24],"fac-":[25],"tors":[26],"mediating":[27],"decline":[28],"health,":[30],"however,":[31],"are":[32],"poorly":[33],"elucidated.":[34],"Pathological":[35],"consequences":[36],"hypothyroid-":[38],"ism":[39],"point":[40],"a":[42],"high":[43],"potential":[44],"for":[45],"antioxidant":[46,105],"imbalance.":[47],"study":[49],"population":[50],"consisted":[51],"60":[53],"subjects":[54],"divided":[55],"into":[56],"two":[57],"groups:":[58],"30":[59,64],"people":[60,206],"with":[61,207],"hypothyroidism":[62,208],"and":[63,101,103,137,184],"age-matched":[65],"healthy":[66,168],"participants.":[67],"We":[68],"examined":[69],"33":[71],"4":[72,73],"levels":[74,129],"total":[76,84],"triiodothyronine":[77,81],"(T":[78,86],"),":[79,83,87,91],"free":[80,88],"(FT":[82,90],"thyroxine":[85,89],"thyroid":[92],"stimulating":[93],"hormone":[94],"(TSH),":[95],"thiobarbituric":[96,155],"acid":[97,156],"reactive":[98,157],"substances":[99,158],"(TBARS),":[100],"enzymatic":[102],"non-enzymatic":[104],"status.":[106],"mean":[108,151],"TSH":[109],"level":[110,152],"was":[111,160],"significantly":[112,140,161,189],"higher":[113,162],"hypothyroid":[115,164,192],"patients":[116,145,165,193],"than":[117,166,194],"44":[118],"3":[119,120],"control":[122,148,196],"subjects.":[123,149],"On":[124],"other":[126],"hand,":[127],"FT":[131,135],",":[132,134,136],"T":[133,138],"were":[139,188],"lower":[141,190],"hypothy-":[143],"roid":[144],"compared":[146],"plasma":[154],"(TBARS)":[159],"controls.":[169],"However,":[170],"activities":[172],"superoxide":[174],"dismutase":[175],"(SOD),":[176],"catalase":[177],"(CAT),":[178],"glutathione":[179,186],"peroxidase":[180],"(GPx),":[181],"glutathione-S-transferase":[182],"(GST),":[183],"reduced":[185,210],"(GSH)":[187],"sub-":[197],"jects.":[198],"Our":[199],"preliminary":[200],"results":[201],"confirm":[202],"hypothesis":[204],"that":[205],"have":[209],"antioxi-":[211],"dative":[212],"defense.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
