{"id":"https://openalex.org/W2183437591","doi":null,"title":"AN OVER VIEW: MICROSPHERES AS A NASAL DRUG DELIVERY SYSTEM Review Article","display_name":"AN OVER VIEW: MICROSPHERES AS A NASAL DRUG DELIVERY SYSTEM Review Article","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2183437591","mag":"2183437591"},"language":"en","primary_location":{"id":"mag:2183437591","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/volume5issue1/article-003.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015470919","display_name":"Amol Chaudhari","orcid":"https://orcid.org/0000-0002-9072-5835","observed_orcids":["https://orcid.org/0000-0002-9072-5835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amol Chaudhari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9072-5835","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058990906","display_name":"Navi Mumbai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Navi Mumbai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microspheres","display_name":"microspheres","score":0.9490000009536743},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9929999709129333},{"id":"https://openalex.org/keywords/starch-microspheres","display_name":"starch microspheres","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dextran-microspheres","display_name":"dextran microspheres","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9089999794960022},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.30399999022483826},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7039999961853027},{"id":"https://openalex.org/keywords/residence-time","display_name":"residence time","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.6797254085540771},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5616151690483093},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5396353006362915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5391306281089783},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4908331334590912},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.46692368388175964},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.4447512924671173},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.4176594913005829},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4170278012752533},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.4116281569004059},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4070511758327484},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.39210155606269836},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3333855867385864},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33088237047195435},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28201621770858765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18760231137275696},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11639299988746643},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09129971265792847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07351958751678467},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183437591","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/volume5issue1/article-003.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1527973685","https://openalex.org/W1578413644","https://openalex.org/W1585017825","https://openalex.org/W1605452004","https://openalex.org/W1973818971","https://openalex.org/W1994287896","https://openalex.org/W1995537132","https://openalex.org/W2027123578","https://openalex.org/W2033348952","https://openalex.org/W2034976569","https://openalex.org/W2035736664","https://openalex.org/W2035961485","https://openalex.org/W2042896447","https://openalex.org/W2047603891","https://openalex.org/W2051502497","https://openalex.org/W2066703723","https://openalex.org/W2069917285","https://openalex.org/W2070182118","https://openalex.org/W2071875012","https://openalex.org/W2073771274","https://openalex.org/W2089895093","https://openalex.org/W2094851123","https://openalex.org/W2100300954","https://openalex.org/W2127836451","https://openalex.org/W2412185540","https://openalex.org/W2419278278","https://openalex.org/W2472580695","https://openalex.org/W2479418228","https://openalex.org/W2504672924"],"related_works":["https://openalex.org/W2069917285","https://openalex.org/W2033348952","https://openalex.org/W1578413644","https://openalex.org/W3202895812","https://openalex.org/W1973818971","https://openalex.org/W2094299539","https://openalex.org/W2056606238","https://openalex.org/W2035736664","https://openalex.org/W2042896447","https://openalex.org/W2082981817"],"abstract_inverted_index":{"All":[0],"types":[1],"of":[2,25,31,51,100,124,153],"microspheres":[3,39,85,120,132],"that":[4],"have":[5,40,68],"been":[6,41,57,69],"used":[7],"as":[8,109,111,117],"nasal":[9],"drug":[10],"delivery":[11],"systems":[12],"are":[13],"water-insoluble":[14],"but":[15],"absorb":[16],"water":[17],"into":[18],"the":[19,26,29,38,49,79,93,98,147,151,157],"sphere\u2019s":[20],"matrix,":[21],"resulting":[22,149],"in":[23,37,59,72,78,150],"swelling":[24],"spheres":[27],"and":[28,45,48,54],"formation":[30],"a":[32,143],"gel.":[33],"The":[34,75,104,122],"building":[35],"materials":[36],"starch,":[42],"dextran,":[43],"albumin":[44],"hyaluronic":[46],"acid,":[47],"bioavailability":[50],"several":[52],"peptides":[53],"proteins":[55],"has":[56],"improved":[58,127],"different":[60],"animal":[61],"models.":[62],"Also,":[63],"some":[64],"low-molecular":[65],"weight":[66],"drugs":[67],"successfully":[70],"delivered":[71],"microsphere":[73,106],"preparations.":[74],"residence":[76],"time":[77],"cavity":[80],"is":[81,91,133],"considerably":[82],"increased":[83],"for":[84,115,126,130],"compared":[86],"to":[87,96,136],"solutions.":[88],"However,":[89],"this":[90],"not":[92],"only":[94],"factor":[95],"increase":[97],"absorption":[99,113,128],"large":[101],"hydrophilic":[102],"drugs.":[103],"dextran":[105,137],"system":[107],"was":[108],"effective":[110],"an":[112],"enhancer":[114],"insulin":[116],"degradable":[118],"starch":[119,131],"(DSM).":[121],"mode":[123],"action":[125],"found":[129],"also":[134,141],"applicable":[135],"micro":[138],"spheres.":[139],"Microspheres":[140],"exert":[142],"direct":[144],"effect":[145],"on":[146],"mucosa,":[148],"opening":[152],"tight":[154],"junctions":[155],"between":[156],"epithelial":[158],"cells.":[159]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}