{"id":"https://openalex.org/W2183397610","doi":null,"title":"C URRENT OPINION Antifungals in severe asthma","display_name":"C URRENT OPINION Antifungals in severe asthma","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2183397610","mag":"2183397610"},"language":"en","primary_location":{"id":"mag:2183397610","doi":null,"is_oa":false,"landing_page_url":"http://knowthecause.com/downloads/Parulakar2014AntifungalDrugsSevereAsthma.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063365600","display_name":"Amit D. Parulekar","orcid":"https://orcid.org/0000-0003-4828-4041","observed_orcids":["https://orcid.org/0000-0003-4828-4041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Parulekar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4828-4041","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040242663","display_name":"Zuzana Diamant","orcid":"https://orcid.org/0000-0003-0133-0100","observed_orcids":["https://orcid.org/0000-0003-0133-0100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuzana Diamant","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0133-0100","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021493691","display_name":"Nicola Alexander Hanania","orcid":"https://orcid.org/0000-0003-3087-9530","observed_orcids":["https://orcid.org/0000-0003-3087-9530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola A. Hanania","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3087-9530","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.996999979019165},{"id":"https://openalex.org/keywords/allergic-bronchopulmonary-aspergillosis","display_name":"allergic bronchopulmonary aspergillosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fungal-allergy","display_name":"fungal allergy","score":0.6029999852180481},{"id":"https://openalex.org/keywords/asthma-pathogenesis","display_name":"asthma pathogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/corticosteroid-requirement","display_name":"corticosteroid requirement","score":0.7990000247955322},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.818489134311676},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8072646856307983},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6486911177635193},{"id":"https://openalex.org/C2778871687","wikidata":"https://www.wikidata.org/wiki/Q1430844","display_name":"Allergic bronchopulmonary aspergillosis","level":4,"score":0.646264910697937},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.5669401288032532},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.5396063923835754},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5346808433532715},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.5039018988609314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2982715964317322},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.18523886799812317},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.1259736716747284},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09770756959915161},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183397610","doi":null,"is_oa":false,"landing_page_url":"http://knowthecause.com/downloads/Parulakar2014AntifungalDrugsSevereAsthma.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1963691990","https://openalex.org/W1967758509","https://openalex.org/W1974893215","https://openalex.org/W1977641934","https://openalex.org/W1988385266","https://openalex.org/W1989345554","https://openalex.org/W1990338160","https://openalex.org/W1997707474","https://openalex.org/W2010825301","https://openalex.org/W2019498378","https://openalex.org/W2020224193","https://openalex.org/W2025943929","https://openalex.org/W2029714817","https://openalex.org/W2033391872","https://openalex.org/W2034196776","https://openalex.org/W2034519404","https://openalex.org/W2035605526","https://openalex.org/W2037893855","https://openalex.org/W2039720197","https://openalex.org/W2041325078","https://openalex.org/W2057309068","https://openalex.org/W2062794121","https://openalex.org/W2063889976","https://openalex.org/W2069178200","https://openalex.org/W2076053525","https://openalex.org/W2078983480","https://openalex.org/W2081632994","https://openalex.org/W2082064241","https://openalex.org/W2084493640","https://openalex.org/W2086167722","https://openalex.org/W2087083075","https://openalex.org/W2088225529","https://openalex.org/W2092701584","https://openalex.org/W2096172855","https://openalex.org/W2098276532","https://openalex.org/W2100341641","https://openalex.org/W2104608591","https://openalex.org/W2105665234","https://openalex.org/W2110118882","https://openalex.org/W2115179464","https://openalex.org/W2119606085","https://openalex.org/W2123257822","https://openalex.org/W2126870687","https://openalex.org/W2127968284","https://openalex.org/W2128690134","https://openalex.org/W2135649656","https://openalex.org/W2138719668","https://openalex.org/W2139627695","https://openalex.org/W2146361081","https://openalex.org/W2147711737","https://openalex.org/W2150817537","https://openalex.org/W2150859631","https://openalex.org/W2152001616","https://openalex.org/W2156755613","https://openalex.org/W2334736861","https://openalex.org/W3140471526"],"related_works":["https://openalex.org/W1987412090","https://openalex.org/W3094799344","https://openalex.org/W2909280710","https://openalex.org/W2020224193","https://openalex.org/W4313575620","https://openalex.org/W2147711737","https://openalex.org/W4205918737","https://openalex.org/W2100644108","https://openalex.org/W3092311087","https://openalex.org/W2084493640"],"abstract_inverted_index":{"Purpose":[0],"of":[1,25,36,47,66,137,145,153,168,184,206],"review":[2,40],"Despite":[3,101],"guideline-based":[4],"treatment,":[5],"many":[6],"patients":[7],"with":[8,58],"severe":[9,26,56,157,188,210],"asthma":[10,57,111,158,189,211,215],"continue":[11],"to":[12,34,80,200],"have":[13,97,163],"uncontrolled":[14],"disease.":[15],"Fungal":[16],"allergy":[17],"is":[18,192,198],"being":[19],"increasingly":[20],"recognized":[21],"in":[22,50,77,84,95,156,176,187,209],"the":[23,32,45,138,203,214],"pathogenesis":[24],"asthma.":[27,38],"Limited":[28],"data":[29,127],"exist":[30],"on":[31,44],"approach":[33],"treatment":[35],"fungal":[37,59],"This":[39],"summarizes":[41],"existing":[42],"evidence":[43],"use":[46,83,94,108,183],"antifungal":[48,154,170,207],"agents":[49,186],"allergic":[51],"bronchopulmonary":[52],"aspergillosis":[53],"(ABPA)":[54],"and":[55,62,118,122,143,178,212],"sensitization":[60],"(SAFS),":[61],"highlights":[63],"needed":[64,199],"areas":[65],"future":[67],"investigation.":[68],"Recent":[69,71],"findings":[70,104],"studies":[72,91,162],"evaluating":[73],"oral":[74,106,174],"triazole":[75,82,93,107],"therapy":[76,155],"ABPA":[78,177,191],"appear":[79],"support":[81],"a":[85,165],"carefully":[86],"considered":[87],"clinical":[88,182],"setting,":[89],"whereas":[90],"assessing":[92],"SAFS":[96],"yielded":[98],"mixed":[99],"results.":[100],"early":[102],"encouraging":[103],"that":[105],"may":[109],"improve":[110],"symptoms,":[112],"stabilize":[113],"lung":[114],"function,":[115],"decrease":[116],"inhaled":[117],"systemic":[119],"corticosteroid":[120],"requirements,":[121],"alter":[123],"serum":[124],"biomarkers,":[125],"overall":[126],"are":[128],"limited.":[129],"Appropriate":[130],"patient":[131],"selection,":[132],"as":[133,135,173],"well":[134],"choice":[136],"optimal":[139],"drug,":[140],"dose,":[141],"frequency,":[142],"duration":[144],"therapy,":[146],"remains":[147,159],"poorly":[148],"defined.":[149],"Summary":[150],"The":[151],"role":[152],"unclear.":[160],"Early":[161],"suggested":[164],"possible":[166],"benefit":[167,218],"some":[169],"agents,":[171],"such":[172,220],"triazoles":[175],"SAFS;":[179],"however,":[180],"routine":[181],"these":[185],"without":[190],"not":[193],"currently":[194],"recommended.":[195],"Further":[196],"research":[197],"better":[201],"delineate":[202],"potential":[204],"utility":[205],"medications":[208],"identify":[213],"populations":[216],"who":[217],"from":[219],"treatment.":[221]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
