{"id":"https://openalex.org/W2183345409","doi":null,"title":"Identification of miRNA-mRNA crosstalk in pancreatic cancer by integrating transcriptome analysis.","display_name":"Identification of miRNA-mRNA crosstalk in pancreatic cancer by integrating transcriptome analysis.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2183345409","mag":"2183345409","pmid":"https://pubmed.ncbi.nlm.nih.gov/25807437"},"language":"en","primary_location":{"id":"pmid:25807437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002782106","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-3317-4480","observed_orcids":["https://orcid.org/0000-0003-3317-4480"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Yang","raw_affiliation_strings":["Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China. yang_jian688@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China. yang_jian688@163.com","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102712010","display_name":"Yuequan Zeng","orcid":"https://orcid.org/0009-0005-2297-1515","observed_orcids":["https://orcid.org/0009-0005-2297-1515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1391,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.735711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"5","first_page":"825","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.6359999775886536},{"id":"https://openalex.org/keywords/differentially-expressed-mirnas","display_name":"differentially expressed miRNAs","score":0.8830000162124634},{"id":"https://openalex.org/keywords/differentially-expressed-mrnas","display_name":"differentially expressed mRNAs","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mir-130b","display_name":"miR-130b","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mir-106b","display_name":"miR-106b","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-181c","display_name":"miR-181c","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-153","display_name":"miR-153","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mir-125a-5p","display_name":"miR-125a-5p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8509654402732849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7048459053039551},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.624952495098114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.618779718875885},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6168621182441711},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6041350364685059},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5644176006317139},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5293315649032593},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5272274017333984},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4857900142669678},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.44266238808631897},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43032407760620117},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.42000243067741394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4024900496006012},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33593907952308655},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2409892976284027}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25807437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2183345409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W57303695","https://openalex.org/W1578780319","https://openalex.org/W1809096633","https://openalex.org/W1946577841","https://openalex.org/W1976284083","https://openalex.org/W1982191152","https://openalex.org/W1985880427","https://openalex.org/W2003395833","https://openalex.org/W2005074066","https://openalex.org/W2010704033","https://openalex.org/W2011925011","https://openalex.org/W2013196466","https://openalex.org/W2020541351","https://openalex.org/W2024041548","https://openalex.org/W2036711926","https://openalex.org/W2045021672","https://openalex.org/W2064316340","https://openalex.org/W2066254965","https://openalex.org/W2073422102","https://openalex.org/W2079062596","https://openalex.org/W2080392221","https://openalex.org/W2080760334","https://openalex.org/W2094636384","https://openalex.org/W2101117089","https://openalex.org/W2102329798","https://openalex.org/W2106403499","https://openalex.org/W2112087504","https://openalex.org/W2125268623","https://openalex.org/W2130720854","https://openalex.org/W2130979840","https://openalex.org/W2135810600","https://openalex.org/W2138155367","https://openalex.org/W2139794819","https://openalex.org/W2142663409","https://openalex.org/W2154086676","https://openalex.org/W2159675211","https://openalex.org/W2163062452","https://openalex.org/W2170077767","https://openalex.org/W2187437179","https://openalex.org/W3134530972"],"related_works":["https://openalex.org/W2895902699","https://openalex.org/W1967417833","https://openalex.org/W2062228625","https://openalex.org/W1423697405","https://openalex.org/W7098929160","https://openalex.org/W3148513700","https://openalex.org/W2957812652","https://openalex.org/W2782943701","https://openalex.org/W4282965196","https://openalex.org/W2011419733"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Pancreatic":[1],"cancer":[2,277],"is":[3],"one":[4],"of":[5,24,34,97,110,128,139,154,182,200,219,272,275,280],"the":[6,11,32,107,150,197,215,245,256,259,270],"most":[7],"lethal":[8],"diseases,":[9],"and":[10,26,36,38,50,71,81,101,136,141,152,184,217,242,253,278],"pathogenesis":[12],"remains":[13],"largely":[14],"unknown.":[15],"To":[16],"this":[17],"end,":[18],"we":[19,87,159,224],"performed":[20,212],"an":[21],"integrated":[22,69,111,201],"analysis":[23,145],"miRNA":[25,35,51,55,61,70,80,155,183,191,220],"mRNA":[27,37,49,72,82,112,185,202],"expression":[28,52,73,113,122,180,203],"data":[29,53],"to":[30,58,76,92,106,115,148,213],"explore":[31],"deregulation":[33],"regulatory":[39,164,229],"processes":[40],"underlying":[41],"pancreatic":[42,65,84,188,276],"cancer.":[43,66,85],"MATERIALS":[44],"AND":[45],"METHODS:":[46],"We":[47,67],"combined":[48],"with":[54,126,258],"target":[56,95,104,156,192,221],"predictions":[57],"infer":[59],"new":[60,267],"regulation":[62],"activities":[63],"in":[64,83,187,196],"first":[68],"profiling":[74,114,204],"separately":[75,186],"identify":[77],"differently":[78,98],"expressed":[79,99,118,169,173],"Then":[86],"adopted":[88],"miRWalk":[89],"databases":[90],"prediction":[91],"obtain":[93],"potential":[94],"genes":[96,105,193],"miRNA,":[100],"compared":[102],"these":[103],"gene":[108,120,163,198,228,234],"list":[109,199],"select":[116],"differentially":[117,168,172],"miRNA-target":[119,162,227,233],"whose":[121],"was":[123,211],"reversely":[124],"correlated":[125],"that":[127],"corresponding":[129],"miRNAs.":[130],"Gene":[131],"Ontology":[132],"(GO)":[133],"classification":[134],"analyses":[135],"Kyoto":[137],"Encyclopedia":[138],"Genes":[140],"Genomes":[142],"(KEGG)":[143],"pathway":[144],"were":[146,175,194,255],"employed":[147],"understand":[149,214],"functions":[151,216],"pathways":[153,218],"genes.":[157,222],"Finally":[158],"construct":[160],"a":[161,226],"network.":[165],"RESULTS:":[166],"42":[167],"miRNAs,":[170],"1376":[171],"mRNAs":[174,257],"identified":[176],"by":[177],"combining":[178],"three":[179,249],"profiles":[181],"cancer,":[189],"146":[190],"found":[195],"based":[205],"on":[206],"bioinformatics":[207],"prediction.":[208],"Functional":[209],"annotation":[210],"Finally,":[223],"constructed":[225],"network":[230],"including":[231],"206":[232],"pairs.":[235],"Five":[236],"miRNAs":[237,250],"(hsa-miR-130b,":[238],"hsa-miR-106b,":[239],"hsa-miR-181c,":[240],"hsa-miR-153":[241],"hsa-miR-125a-5p)":[243],"demonstrated":[244],"highest":[246,260],"connectivities,":[247],"whereas":[248],"(MYC,":[251],"E2F1":[252],"IL6)":[254],"connectivities.":[261],"CONCLUSIONS:":[262],"Our":[263],"findings":[264],"may":[265],"provide":[266],"insights":[268],"into":[269],"knowledge":[271],"molecular":[273],"mechanisms":[274],"development":[279],"novel":[281],"targeting":[282],"therapies.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
