{"id":"https://openalex.org/W2183341267","doi":null,"title":"Peroxisome proliferator activated receptor gamma immunohistochemical expression in human papillary thyroid carcinoma tissues. Possible relationship to lymph node metastasis.","display_name":"Peroxisome proliferator activated receptor gamma immunohistochemical expression in human papillary thyroid carcinoma tissues. Possible relationship to lymph node metastasis.","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2183341267","mag":"2183341267","pmid":"https://pubmed.ncbi.nlm.nih.gov/15274390"},"language":"en","primary_location":{"id":"pmid:15274390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004709224","display_name":"Bogdan Galusca","orcid":"https://orcid.org/0000-0002-0154-6924","observed_orcids":["https://orcid.org/0000-0002-0154-6924"]},"institutions":[{"id":"https://openalex.org/I4210157006","display_name":"Centre Hospitalier Universitaire de Saint-\u00c9tienne","ror":"https://ror.org/04pn6vp43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210157006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bogdan Galusca","raw_affiliation_strings":["Department of Endocrinology, Bellevue Hospital, St-Etienne University Hospital Center, Saint-Etienne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Bellevue Hospital, St-Etienne University Hospital Center, Saint-Etienne, France","institution_ids":["https://openalex.org/I4210157006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064210740","display_name":"Jean Marc Dumollard","orcid":"https://orcid.org/0000-0003-2901-4775","observed_orcids":["https://orcid.org/0000-0003-2901-4775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Marc Dumollard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042110242","display_name":"Marie Laure Chambonni\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Laure Chambonniere","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054426093","display_name":"Natacha Germain","orcid":"https://orcid.org/0000-0001-6949-7244","observed_orcids":["https://orcid.org/0000-0001-6949-7244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natacha Germain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529338","display_name":"Jean Michel Prades","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Michel Prades","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068076170","display_name":"Michel P\u00e9oc\u2019h","orcid":"https://orcid.org/0000-0001-5453-0021","observed_orcids":["https://orcid.org/0000-0001-5453-0021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel P\u00e9oc'h","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031367270","display_name":"Bruno Estour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Estour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1275,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78208209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"3b","first_page":"1993","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9409999847412109},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/follicular-thyroid-adenoma","display_name":"follicular adenoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hurthle-cell-adenoma","display_name":"Hurthle cell adenoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nuclear-receptor-expression","display_name":"nuclear receptor expression","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6786348223686218},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6736411452293396},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6318973898887634},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6089590787887573},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5692199468612671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5049834847450256},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.47605153918266296},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4742801785469055},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4609222412109375},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4496656656265259},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4125405550003052},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3141395151615143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3087509274482727}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15274390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2183341267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1670226482","https://openalex.org/W1968460133","https://openalex.org/W1975160900","https://openalex.org/W1991050772","https://openalex.org/W1993342645","https://openalex.org/W2022048961","https://openalex.org/W2043534129","https://openalex.org/W2045833013","https://openalex.org/W2046003494","https://openalex.org/W2070252680","https://openalex.org/W2073412031","https://openalex.org/W2102021118","https://openalex.org/W2118122421","https://openalex.org/W2136528210","https://openalex.org/W2160114980","https://openalex.org/W2163244708"],"related_works":["https://openalex.org/W2021591676","https://openalex.org/W2085224017","https://openalex.org/W2349315850","https://openalex.org/W2046003494","https://openalex.org/W6903061795","https://openalex.org/W2155634234","https://openalex.org/W2374060015","https://openalex.org/W2133707679","https://openalex.org/W2337715264","https://openalex.org/W2043771662"],"abstract_inverted_index":{"BACKGROUND:":[0],"Peroxisome":[1],"proliferator":[2],"activated":[3],"receptor":[4,26],"gamma":[5],"(PPARgamma)":[6],"involvement":[7],"in":[8,16,27,41,44,121,132,203],"thyroid":[9,50,72,236],"tumorigenesis":[10],"has":[11],"recently":[12,193],"been":[13,32],"studied,":[14],"especially":[15],"follicular":[17,77,81],"neoplasms.":[18],"Conflicting":[19],"results":[20],"concerning":[21],"the":[22,198],"regulation":[23],"of":[24,49,60,125,147,153,162,245],"this":[25],"human":[28,71],"papillary":[29,42,73,246],"carcinoma":[30,43,247],"have":[31],"reported.":[33],"Therefore,":[34],"we":[35,53],"quantitatively":[36],"assessed":[37],"PPARgamma":[38,117,200,220,225,258],"immunohistochemical":[39],"expression":[40,118,221],"comparison":[45],"with":[46,57,181,192],"other":[47,165],"types":[48],"tumors":[51,183,237],"and":[52,84,222,249],"evaluated":[54],"its":[55],"relationship":[56,218],"clinical":[58],"criteria":[59],"aggressiveness.":[61],"MATERIALS":[62],"AND":[63],"METHODS:":[64],"Immunohistochemistry":[65],"(IHC)":[66],"was":[67,107,119,174],"performed":[68],"on":[69],"56":[70],"carcinomas":[74,78],"(PTC),":[75],"9":[76],"(FTC),":[79],"20":[80],"adenomas":[82],"(FA)":[83],"18":[85],"H\u00fcrthle":[86,139],"cells":[87],"adenomas.":[88],"PTC":[89,126,180,204],"were":[90],"divided":[91],"into":[92],"subgroups":[93],"according":[94],"to":[95,129,208],"some":[96],"aggressiveness":[97,248],"criteria:":[98],"tumor":[99,223],"size,":[100],"capsular":[101],"invasion,":[102],"lymph":[103,155],"node":[104,156],"metastasis.":[105],"Immunostaining":[106],"semi-quantitatively":[108],"analyzed":[109],"using":[110],"image":[111],"analysis":[112],"software.":[113],"RESULTS:":[114],"Strong":[115],"nuclear":[116],"detected":[120],"a":[122,143,159,171,216,230,242,250],"large":[123,179],"number":[124],"(42%),":[127],"similar":[128],"that":[130,197],"found":[131],"FTC":[133],"(44%)":[134],"or":[135],"FA":[136],"(63%).":[137],"Only":[138],"cell":[140],"adenoma":[141],"showed":[142,158],"significantly":[144],"lower":[145],"proportion":[146],"PPARgamma-positive":[148],"immunoreactivity":[149],"(11%,":[150],"p<0.05).":[151,187],"Cases":[152],"PTC-associated":[154],"metastasis":[157],"higher":[160],"percentage":[161],"PPARgamma-positivity":[163],"than":[164],"case":[166],"categories":[167],"(63%":[168],"vs.":[169,185],"20%),":[170],"result":[172],"which":[173],"also":[175],"noticed":[176],"when":[177],"comparing":[178],"infracentimentric":[182],"(60%":[184],"39%,":[186],"CONCLUSION:":[188],"These":[189],"results,":[190],"combined":[191],"published":[194],"data,":[195],"suggest":[196],"intense":[199],"immunostaining":[201],"revealed":[202],"could":[205,240],"be":[206,241],"related":[207],"high":[209],"wtPPARgamma":[210],"gene":[211],"levels.":[212],"Moreover,":[213],"they":[214],"corroborate":[215],"strong":[217],"between":[219],"progression.":[224],"IHC":[226],"evaluation":[227],"is":[228],"not":[229],"valuable":[231],"differential":[232],"diagnostic":[233],"tool":[234],"for":[235,253],"but":[238],"it":[239],"reliable":[243],"marker":[244],"potential":[251],"predictor":[252],"an":[254],"eventual":[255],"therapy":[256],"by":[257],"agonists.":[259]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
