{"id":"https://openalex.org/W2183299244","doi":null,"title":"Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer.","display_name":"Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer.","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2183299244","mag":"2183299244","pmid":"https://pubmed.ncbi.nlm.nih.gov/24344016"},"language":"en","primary_location":{"id":"pmid:24344016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24344016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tianrong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091044","display_name":"First People's Hospital of Yunnan Province","ror":"https://ror.org/00c099g34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091044"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianrong Li","raw_affiliation_strings":["Cadre Wards, the First People's Hospital of Yunnan Province, Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cadre Wards, the First People's Hospital of Yunnan Province, Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4210091044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077910504","display_name":"Jie Li Lu","orcid":"https://orcid.org/0000-0003-1097-4450","observed_orcids":["https://orcid.org/0000-0003-1097-4450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100902319","display_name":"Yunhua Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunhua Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6449,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70246734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"4","first_page":"908","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lentivirus-mediated-rna-interference","display_name":"lentivirus-mediated RNA interference","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":1.0},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":1.0},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7320214509963989},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6981071829795837},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6324018836021423},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.6193228960037231},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.6190761923789978},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6040839552879333},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5889269709587097},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.5816349387168884},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5654470920562744},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5019142627716064},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4839628040790558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48227646946907043},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3804464340209961},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3550604581832886},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3263047933578491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28935545682907104},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.168678879737854},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13554462790489197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09654128551483154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24344016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24344016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},{"id":"mag:2183299244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24344016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1506887248","https://openalex.org/W1518353833","https://openalex.org/W1525556816","https://openalex.org/W1647640400","https://openalex.org/W1966393652","https://openalex.org/W1967205648","https://openalex.org/W1967257081","https://openalex.org/W1977785973","https://openalex.org/W1978775455","https://openalex.org/W1985231066","https://openalex.org/W2005667069","https://openalex.org/W2029523161","https://openalex.org/W2051175326","https://openalex.org/W2063556410","https://openalex.org/W2069305322","https://openalex.org/W2076744535","https://openalex.org/W2078275617","https://openalex.org/W2078935333","https://openalex.org/W2089218510","https://openalex.org/W2093115805","https://openalex.org/W2104701964","https://openalex.org/W2105372476","https://openalex.org/W2108527141","https://openalex.org/W2119689902","https://openalex.org/W2123926330","https://openalex.org/W2126602752","https://openalex.org/W2129746660","https://openalex.org/W2135535670","https://openalex.org/W2136789423","https://openalex.org/W2144548546","https://openalex.org/W2147753291","https://openalex.org/W2148122132","https://openalex.org/W2150966393","https://openalex.org/W2161340164","https://openalex.org/W2169623192","https://openalex.org/W2395241797","https://openalex.org/W2416779664"],"related_works":["https://openalex.org/W2392109395","https://openalex.org/W1967205648","https://openalex.org/W2525534466","https://openalex.org/W2947623688","https://openalex.org/W1991511427","https://openalex.org/W2005490924","https://openalex.org/W945118433","https://openalex.org/W2006792529","https://openalex.org/W2071191186","https://openalex.org/W2042633102"],"abstract_inverted_index":{"PURPOSE:":[0],"Cyclooxygenase-2":[1],"(COX-2),":[2],"one":[3],"isoform":[4],"of":[5,19,27,32,39,44,70,82,158,171,178,186,217],"cyclooxygenase":[6],"proinflammatory":[7],"enzymes,":[8],"plays":[9],"an":[10],"important":[11],"role":[12],"in":[13,29,41,84],"tumor":[14],"development":[15],"and":[16,90,98,104,111,124,142,149,154,166,192,196,204],"progression.":[17],"Researches":[18],"human":[20,71],"cancers":[21,33],"have":[22],"revealed":[23],"high":[24],"expression":[25,81,127,151,185],"levels":[26],"COX-2":[28,40,66,83,147,159,179,203],"a":[30,58,210],"variety":[31],"including":[34,120],"lung":[35,47],"cancer.":[36],"The":[37,88,101],"mechanism":[38],"the":[42,68,80,164,184,215],"pathogenesis":[43],"non-small":[45],"cell":[46,86,102,105,168,173,187],"cancer":[48],"(NSCLC)":[49],"cells":[50],"is":[51],"not":[52],"well":[53],"understood.":[54],"METHODS:":[55],"We":[56],"constructed":[57],"lentivirus":[59,138],"vector":[60,139],"mediated":[61,180],"RNA":[62],"interference":[63],"(RNAi)":[64],"targeting":[65],"for":[67,214],"treatment":[69,216],"NSCLC":[72,85,172],"cells.":[73],"RNAi":[74],"technology":[75],"was":[76,92,128,132,140,152],"used":[77],"to":[78],"knockdown":[79,157],"lines.":[87,174],"efficiency":[89],"specificity":[91],"validated":[93],"by":[94,109,130,160,181],"quantitative":[95],"real-time":[96],"PCR":[97],"western":[99],"blotting.":[100],"growth":[103,165],"cycle":[106,169],"were":[107],"determined":[108],"MTT":[110],"flow":[112],"cytometry":[113],"assay,":[114],"respectively.":[115],"Cell":[116],"cycle-regulated":[117,188],"gene":[118],"expression,":[119],"cyclin":[121,194],"D1,":[122],"p21":[123,191],"survivin,":[125],"whose":[126],"modulated":[129,183],"COX-2,":[131],"also":[133],"examined.":[134],"RESULTS:":[135],"LV-COX-2-silencing":[136],"(si)RNA":[137],"effective":[141],"its":[143,205],"inhibitory":[144],"effects":[145],"on":[146],"mRNA":[148],"protein":[150],"efficient":[153],"specific.":[155],"Gene":[156],"LV-COX-2-siRNA":[161,182],"significantly":[162],"inhibited":[163],"induced":[167],"arrest":[170],"In":[175],"addition,":[176],"silence":[177],"gene,":[189],"upregulating":[190],"downregulating":[193],"D1":[195],"survivin.":[197],"CONCLUSIONS:":[198],"Our":[199],"findings":[200],"imply":[201],"that":[202],"signaling":[206],"pathway":[207],"may":[208],"provide":[209],"novel":[211],"therapeutic":[212],"target":[213],"NSCLC.":[218]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
