{"id":"https://openalex.org/W2183220134","doi":null,"title":"Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment","display_name":"Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2183220134","mag":"2183220134"},"language":"en","primary_location":{"id":"mag:2183220134","doi":null,"is_oa":false,"landing_page_url":"https://www.termedia.pl/Journal/-10/pdf-11557-1?filename=13_Antibodies.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.termedia.pl/Journal/-10/pdf-11557-1?filename=13_Antibodies.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Medhat Haroun","orcid":"https://orcid.org/0000-0002-3511-7765","observed_orcids":["https://orcid.org/0000-0002-3511-7765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Medhat Haroun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3511-7765","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111372144","display_name":"Mohamed H. El-Masry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed H. El-Masry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.391,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66520979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-thyroid-disease","display_name":"autoimmune thyroid disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anti-immunoglobulin-antibodies","display_name":"anti-immunoglobulin antibodies","score":0.8999999761581421},{"id":"https://openalex.org/keywords/serum-iga","display_name":"serum IgA","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":1.0},{"id":"https://openalex.org/keywords/anti-thyroid-antibodies","display_name":"anti-thyroid antibodies","score":0.9139999747276306},{"id":"https://openalex.org/keywords/elisa-interference","display_name":"ELISA interference","score":0.5429999828338623},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.8153146505355835},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5862362384796143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.578236997127533},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5539335012435913},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5439162254333496},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.519770085811615},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.48475882411003113},{"id":"https://openalex.org/C50181227","wikidata":"https://www.wikidata.org/wiki/Q1943709","display_name":"Anti-thyroid autoantibodies","level":4,"score":0.48241886496543884},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4566267430782318},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45454663038253784},{"id":"https://openalex.org/C180650514","wikidata":"https://www.wikidata.org/wiki/Q419502","display_name":"Thyroid peroxidase","level":3,"score":0.4306444227695465},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.4108673334121704},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4084237813949585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4059704542160034}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2183220134","doi":null,"is_oa":false,"landing_page_url":"https://www.termedia.pl/Journal/-10/pdf-11557-1?filename=13_Antibodies.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2608454754","doi":null,"is_oa":true,"landing_page_url":"https://www.termedia.pl/Journal/-10/pdf-11557-1?filename=13_Antibodies.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1004891435","display_name":"Central European Journal of Immunology","issn_l":"1426-3912","issn":["1426-3912","1644-4124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Central European Journal of Immunology","raw_type":null}],"best_oa_location":{"id":"mag:2608454754","doi":null,"is_oa":true,"landing_page_url":"https://www.termedia.pl/Journal/-10/pdf-11557-1?filename=13_Antibodies.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1004891435","display_name":"Central European Journal of Immunology","issn_l":"1426-3912","issn":["1426-3912","1644-4124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Central European Journal of Immunology","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1512835103","https://openalex.org/W1522588191","https://openalex.org/W1965107806","https://openalex.org/W1976518863","https://openalex.org/W1988295223","https://openalex.org/W1997539630","https://openalex.org/W2007435633","https://openalex.org/W2015023782","https://openalex.org/W2016193783","https://openalex.org/W2022815666","https://openalex.org/W2044157028","https://openalex.org/W2056469382","https://openalex.org/W2058266410","https://openalex.org/W2078610240","https://openalex.org/W2084855813","https://openalex.org/W2100837269","https://openalex.org/W2103258601","https://openalex.org/W2121987591","https://openalex.org/W2130716181","https://openalex.org/W2168646822","https://openalex.org/W2335288680","https://openalex.org/W2399274800","https://openalex.org/W3000168737"],"related_works":["https://openalex.org/W2012793794","https://openalex.org/W2608454754","https://openalex.org/W4388613228","https://openalex.org/W2419362756","https://openalex.org/W2365904915","https://openalex.org/W7064410977","https://openalex.org/W2291658662","https://openalex.org/W2359115451","https://openalex.org/W167629513","https://openalex.org/W2610612077"],"abstract_inverted_index":{"Autoimmune":[0],"thyroid":[1,22,30],"diseases":[2],"(ATD)":[3],"are":[4],"organ-specific":[5],"autoimmune":[6],"disorders":[7],"namely,":[8],"Hashimoto\u2019s":[9],"thyroiditis":[10],"and":[11,24,57,99,111,139,180,188,205,210,294],"Graves\u2019":[12],"disease,":[13],"characterized":[14],"by":[15,50,121,258],"the":[16,21,29,40,52,60,64,67,153,213,273,301],"production":[17],"of":[18,34,54,66,87,94,125,133,165,183,200,216,251,256],"antibodies":[19,72,110,128,157],"against":[20],"peroxidase":[23],"thyroid-stimulating":[25],"hormone":[26],"receptor":[27],"in":[28,47,85,90,101,137,167,218,237,240,289,300],"gland.":[31],"The":[32,123],"purpose":[33],"this":[35],"study":[36],"was":[37,171,225,233],"to":[38,58,81,130,227,245,268],"optimize":[39],"ELISA":[41],"tests":[42],"for":[43,142],"quantifying":[44],"serum":[45,95,134,144],"immunoglobulins":[46,77,224,263,282],"ATD":[48,91,106,138,160,196,219,243,293],"patients":[49,104,161,241],"minimizing":[51],"interference":[53],"anti-goat":[55,126,155,223,252,262],"immunoglobulin":[56,88,96,127,156,253,278],"evaluate":[59],"prevalence":[61],"effect":[62,124],"on":[63],"measurement":[65],"humoral":[68],"immune":[69],"response.":[70],"Anti-immunoglobulin":[71],"were":[73,119,266,270],"defined":[74],"using":[75],"goat":[76],"as":[78],"a":[79,298],"target":[80],"characterize":[82],"distinct":[83],"changes":[84],"patterns":[86],"levels":[89,164,182,199,288],"patients.":[92],"Concentrations":[93],"A,":[97],"G":[98],"M":[100],"thirty":[102,112],"five":[103,113],"with":[105,107,242,272,280,292],"positive":[108],"anti-thyroid":[109],"matched":[114],"normal":[115,174,246],"healthy":[116],"adult":[117,290],"individuals":[118,175,193,247],"tested":[120],"ELISA.":[122],"leads":[129],"an":[131],"overestimation":[132],"IgA":[135,166,217,238,257],"level":[136,215,239],"is":[140,283],"different":[141],"each":[143],"sample":[145],"tested.":[146],"Initial":[147],"results":[148],"obtained":[149],"before":[150],"purification":[151],"from":[152,195,222],"interfering":[154],"suggested":[158],"that":[159,173,261],"had":[162,176,197],"increased":[163,287],"their":[168],"sera.":[169],"It":[170],"found":[172],"mean":[177,198,214],"IgA,":[178],"IgG":[179],"IgM":[181],"2.75":[184],"mg/ml,":[185,190,202],"9.67":[186],"mg/ml":[187,204,207],"1.81":[189],"respectively":[191],"while":[192],"suffering":[194],"5.01":[201],"10.17":[203],"1.92":[206],"(p<0.0004,":[208],"p<0.20":[209],"p<0.34).":[211],"However,":[212],"sera":[220],"treated":[221],"determined":[226],"be":[228],"2.81":[229],"mg/ml.":[230],"Therefore,":[231],"there":[232],"no":[234],"significant":[235],"difference":[236],"compared":[244],"(p<0.63)":[248],"after":[249],"removal":[250],"antibodies.":[254],"Visualization":[255],"immunoblotting":[259],"confirms":[260],"antibodies,":[264],"which":[265],"unrelated":[267],"antigen,":[269],"co-precipitated":[271],"antigen-antibody":[274],"complex.":[275],"A":[276],"circulating":[277],"reacting":[279],"other":[281],"thus":[284],"present":[285],"at":[286],"subjects":[291],"may":[295],"well":[296],"play":[297],"part":[299],"complex":[302],"immunopathogenetic":[303],"interactions.":[304]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}