{"id":"https://openalex.org/W2183195084","doi":null,"title":"Relationship of p53 expression with clinicopathological variables and disease outcome: a prospective study on 315 consecutive breast carcinoma patients.","display_name":"Relationship of p53 expression with clinicopathological variables and disease outcome: a prospective study on 315 consecutive breast carcinoma patients.","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2183195084","mag":"2183195084","pmid":"https://pubmed.ncbi.nlm.nih.gov/12166594"},"language":"en","primary_location":{"id":"pmid:12166594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103285168","display_name":"Syed A. Aziz","orcid":"https://orcid.org/0000-0001-6959-8272","observed_orcids":["https://orcid.org/0000-0001-6959-8272"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"S A Aziz","raw_affiliation_strings":["Department of Pathology, The Aga Khan University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Aga Khan University, Pakistan","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022156956","display_name":"Shahid Pervez","orcid":"https://orcid.org/0000-0003-3556-1687","observed_orcids":["https://orcid.org/0000-0003-3556-1687","https://orcid.org/0000-0001-6770-3390"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"S Pervez","raw_affiliation_strings":["Aga Khan University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University;","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067908915","display_name":"Sultan Zeb Khan","orcid":"https://orcid.org/0000-0001-5137-1272","observed_orcids":["https://orcid.org/0000-0001-5137-1272"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"S Khan","raw_affiliation_strings":["Aga Khan University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University;","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109292948","display_name":"Naila Kayani","orcid":"https://orcid.org/0000-0002-5306-4257","observed_orcids":["https://orcid.org/0000-0002-5306-4257"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"N Kayani","raw_affiliation_strings":["Aga Khan University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University;","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080783038","display_name":"Mohammad Hossein Rahbar","orcid":"https://orcid.org/0000-0001-6705-9603","observed_orcids":["https://orcid.org/0000-0001-6705-9603"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"M H Rahbar","raw_affiliation_strings":["Aga Khan University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aga Khan University;","institution_ids":["https://openalex.org/I118185606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118185606"],"apc_list":null,"apc_paid":null,"fwci":0.1206,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47767617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"2","first_page":"65","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-overexpression","display_name":"p53 overexpression","score":0.890999972820282},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/axillary-lymph-node-metastasis","display_name":"axillary lymph node metastasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8679999709129333},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9829999804496765},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/high-risk-patient-subgroups","display_name":"high-risk patient subgroups","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8116796016693115},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7449178695678711},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.6456000804901123},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6262509822845459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6079773306846619},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5234905481338501},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5048184990882874},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4989619255065918},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4808807671070099},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4738460183143616},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46870869398117065},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.46272531151771545},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.46146160364151},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.44674596190452576},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35135042667388916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.331799179315567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12166594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:ecommons.aku.edu:pakistan_fhs_mc_pathol_microbiol-2099","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/1100","pdf_url":null,"source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology and Laboratory Medicine","raw_type":"article"},{"id":"mag:2183195084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12166594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1511967417","https://openalex.org/W1599113155","https://openalex.org/W1834833779","https://openalex.org/W1972238770","https://openalex.org/W2005273151","https://openalex.org/W2006749087","https://openalex.org/W2010240655","https://openalex.org/W2062851539","https://openalex.org/W2081220090","https://openalex.org/W2139991681","https://openalex.org/W2161609884","https://openalex.org/W2162975775","https://openalex.org/W2265031510","https://openalex.org/W2409334212","https://openalex.org/W2417622858","https://openalex.org/W2433032207"],"related_works":["https://openalex.org/W6999125387","https://openalex.org/W2005819738","https://openalex.org/W2433032207","https://openalex.org/W2512635665","https://openalex.org/W2034521896","https://openalex.org/W1990094502","https://openalex.org/W2044745912","https://openalex.org/W2419349840","https://openalex.org/W6995885983","https://openalex.org/W2082433570"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,22],"is":[2,215],"an":[3],"increasingly":[4],"important":[5],"cause":[6],"of":[7,20,30,34,48,69,80,84,113,129,135,156,216,222,235],"illness":[8],"and":[9,60,100,141,148,173,198],"death":[10],"among":[11],"women.":[12],"In":[13,44,63,189],"recent":[14],"years":[15,172,197],"several":[16],"novel":[17],"prognostic":[18],"determinants":[19],"breast":[21,42,53,85,223],"have":[23,207],"been":[24],"identified":[25],"which":[26],"includes":[27],"p53.":[28],"Alterations":[29],"p53":[31,49,70,114,130,136,162,181,212],"are":[32,227],"one":[33],"the":[35,67,165,192,199,209],"most":[36],"common":[37],"abnormalities":[38],"detected":[39],"in":[40,50,117,161,218,238],"primary":[41,51],"cancer.":[43],"this":[45,64,190],"study":[46,66],"alteration":[47],"carcinoma":[52,83,224],"was":[54,72,104,115,170,178,195,201],"correlated":[55],"with":[56,127],"other":[57],"pathological":[58],"variables":[59],"disease":[61,110,174],"outcome.":[62,111],"prospective":[65],"expression":[68],"oncoprotein":[71],"analyzed":[73],"immunohistochemically":[74],"on":[75],"315":[76],"patient's":[77],"tumour":[78,183],"specimens":[79],"infiltrating":[81],"ductal":[82],"from":[86],"1992":[87],"to":[88,106,144,243],"1997.":[89],"These":[90],"patients":[91,137,184,225],"also":[92,233],"had":[93,124],"axillary":[94],"lymph":[95,121],"nodes":[96],"sampling.":[97],"Both":[98],"univariate":[99],"multivariate":[101],"statistical":[102],"analysis":[103],"performed":[105],"analyze":[107],"results":[108],"including":[109],"Overexpression":[112],"observed":[116],"55.23%":[118],"tumours.":[119],"Axillary":[120],"node":[122],"metastasis":[123],"significant":[125,133],"correlation":[126],"positivity":[128],"(p<0.05).":[131],"A":[132],"number":[134],"developed":[138],"local":[139],"recurrence":[140],"distant":[142],"metastases":[143],"brain,":[145],"liver,":[146],"lung":[147],"bone":[149],"(p<":[150],"0.05).":[151],"At":[152],"a":[153,186,220],"median":[154,166,193],"follow-up":[155],"48":[157],"months":[158],"(4":[159],"years)":[160],"positive":[163],"patients,":[164],"overall":[167],"survival":[168,176],"(OS)":[169],"3.0":[171],"free":[175],"(DFS)":[177],"2.5":[179],"years.":[180,203],"negative":[182],"showed":[185],"better":[187],"survival.":[188],"group":[191],"OS":[194],"3.8":[196],"DFS":[200],"3.3":[202],"The":[204],"above":[205],"findings":[206],"reinforced":[208],"view":[210],"that":[211],"immunohistochemical":[213],"detection":[214],"help":[217],"detecting":[219],"subgroup":[221],"who":[226],"at":[228],"high":[229],"risk.":[230],"This":[231],"may":[232],"be":[234],"particular":[236],"relevance":[237],"decisions":[239],"regarding":[240],"adjuvant":[241],"chemotherapy":[242],"these":[244],"patients.":[245]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}