{"id":"https://openalex.org/W2183077992","doi":null,"title":"4-substituted coumarins as promising acetylcholinesterase inhibitors","display_name":"4-substituted coumarins as promising acetylcholinesterase inhibitors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2183077992","mag":"2183077992"},"language":"en","primary_location":{"id":"mag:2183077992","doi":null,"is_oa":false,"landing_page_url":"https://journals.tbzmed.ac.ir/PHARM/Document/18thIranianPharmacy/fatemeh%20abolghasemi172.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024402036","display_name":"Fatemeh Abolghasemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatemeh Abolghasemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086778225","display_name":"Akram Mohammadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akram Mohammadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025742744","display_name":"Fariba Mousavipour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fariba Mousavipour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18246805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-hydroxycoumarin-derivatives","display_name":"4-hydroxycoumarin derivatives","score":0.8849999904632568},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/enzyme-selectivity","display_name":"enzyme selectivity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8149999976158142},{"id":"https://openalex.org/keywords/peripheral-anionic-site","display_name":"peripheral anionic site","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pi-pi-stacking","display_name":"\u03c0-\u03c0 stacking","score":0.6800000071525574},{"id":"https://openalex.org/keywords/coumarin-synthesis","display_name":"coumarin synthesis","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.897851288318634},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.8652819395065308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8289831876754761},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7702547311782837},{"id":"https://openalex.org/C158685282","wikidata":"https://www.wikidata.org/wiki/Q429766","display_name":"Electrophorus","level":5,"score":0.7506248950958252},{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.7109590172767639},{"id":"https://openalex.org/C2776730177","wikidata":"https://www.wikidata.org/wiki/Q421721","display_name":"Acetamide","level":2,"score":0.6726822853088379},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6501022577285767},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5206295847892761},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5081348419189453},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4894980192184448},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4491793215274811},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41474467515945435},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.4141119122505188},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32676053047180176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26124054193496704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24365264177322388},{"id":"https://openalex.org/C123419017","wikidata":"https://www.wikidata.org/wiki/Q7826734","display_name":"Torpedo","level":4,"score":0.1293978989124298},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09764871001243591},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.06376320123672485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.044781506061553955},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2183077992","doi":null,"is_oa":false,"landing_page_url":"https://journals.tbzmed.ac.ir/PHARM/Document/18thIranianPharmacy/fatemeh%20abolghasemi172.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068561903","https://openalex.org/W4404313005","https://openalex.org/W4408042265","https://openalex.org/W2118171421","https://openalex.org/W7098923701","https://openalex.org/W2152263560","https://openalex.org/W3093946970","https://openalex.org/W2946641946","https://openalex.org/W4412763928","https://openalex.org/W3134452099"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,58,84,94,111],"4-hydroxycoumarin":[3],"derivatives":[4],"were":[5],"designed":[6],"and":[7,33,50,72,92],"synthesized":[8],"as":[9],"new":[10],"acetylcholinesterase":[11,31],"(AChE)":[12],"inhibitors,":[13],"which":[14],"could":[15,98],"be":[16],"considered":[17],"for":[18,69],"Alzheimer's":[19],"disease":[20],"therapeutics.":[21],"Among":[22],"the":[23,59,82,100,103,112],"19":[24],"coumarin-derived":[25],"compounds":[26],"tested":[27],"toward":[28],"Electrophorus":[29],"electricus":[30],"(eelAChE)":[32],"horse":[34],"serum":[35],"butyrylcholinesterase":[36],"(eqBChE),":[37],"N-(1-benzylpiperidin-4-yl)acetamide":[38],"derivative":[39],"4m":[40],"displayed":[41],"highest":[42],"AChE":[43],"inhibitory":[44],"activity":[45],"(IC50":[46],"=":[47],"1.2":[48],"\u00b5M)":[49],"favorable":[51],"selectivity":[52],"(37":[53],"times).":[54],"The":[55],"docking":[56],"study":[57],"most":[60],"potent":[61,109],"compound":[62],"4m,":[63],"indicated":[64],"that":[65],"Phe330":[66],"is":[67],"responsible":[68],"ligand":[70,101],"recognition":[71],"trafficking":[73],"by":[74],"forming":[75],"p-cation":[76],"interaction":[77,88],"with":[78],"benzylpiperidine":[79],"moiety.":[80],"Furthermore,":[81],"formation":[83],"an":[85],"additional":[86],"pi-pi":[87],"between":[89],"coumarin":[90],"moiety":[91],"Trp279":[93],"peripheral":[95],"anionic":[96],"site":[97,105],"stabilize":[99],"in":[102,107],"active":[104],"resulting":[106],"more":[108],"inhibition":[110],"enzyme.":[113]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}