{"id":"https://openalex.org/W2182992575","doi":"https://doi.org/10.82308/10808","title":"The role of Collapsin Response Mediator Protein 1 (CRMP1) on cell migration and invasion in glioma","display_name":"The role of Collapsin Response Mediator Protein 1 (CRMP1) on cell migration and invasion in glioma","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2182992575","doi":"https://doi.org/10.82308/10808","mag":"2182992575"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.mcgill.ca:2801ph90g","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","pdf_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025657952","display_name":"Jonah S. Shiroky","orcid":"https://orcid.org/0000-0003-1113-9676","observed_orcids":["https://orcid.org/0000-0003-1113-9676"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shiroky, Jonah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025657952"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/crmp2","display_name":"CRMP2","score":0.921999990940094},{"id":"https://openalex.org/keywords/crmp4","display_name":"CRMP4","score":1.0},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.4860000014305115},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.578000009059906},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5389999747276306},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.3449999988079071},{"id":"https://openalex.org/keywords/glioma-cell-lines","display_name":"glioma cell lines","score":0.6230000257492065},{"id":"https://openalex.org/keywords/u87","display_name":"U87","score":0.5299999713897705},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.3709999918937683},{"id":"https://openalex.org/keywords/thymidine-kinase","display_name":"thymidine kinase","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.7865287065505981},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5120844841003418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4065658152103424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33920103311538696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32621967792510986}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:escholarship.mcgill.ca:2801ph90g","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","pdf_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:doi:10.82308/10808","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14905/133222","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"https://vocabularies.coar-repositories.org/resource_types/c_46ec/"},{"id":"pmh:oai:collectionscanada.gc.ca:QMM.40674","doi":null,"is_oa":false,"landing_page_url":"http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40674","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:digitool.library.mcgill.ca:40674","doi":null,"is_oa":false,"landing_page_url":"http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40674","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:oai:mcgill.scholaris.ca:20.500.14905/133222","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.82308/10808","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"https://vocabularies.coar-repositories.org/resource_types/c_46ec/"},{"id":"doi:10.82308/10808","doi":"https://doi.org/10.82308/10808","is_oa":true,"landing_page_url":"https://doi.org/10.82308/10808","pdf_url":null,"source":{"id":"https://openalex.org/S7407060097","display_name":"McGill-DEV","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"pmh:oai:escholarship.mcgill.ca:2801ph90g","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","pdf_url":"https://escholarship.mcgill.ca/concern/theses/2801ph90g","source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182992575.pdf","grobid_xml":"https://content.openalex.org/works/W2182992575.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W1486755303","https://openalex.org/W1487136062","https://openalex.org/W1521626316","https://openalex.org/W1524612873","https://openalex.org/W1531661357","https://openalex.org/W1560323926","https://openalex.org/W1564192489","https://openalex.org/W1596187859","https://openalex.org/W1667693530","https://openalex.org/W1788354698","https://openalex.org/W1806270851","https://openalex.org/W1829894342","https://openalex.org/W1931464619","https://openalex.org/W1957508267","https://openalex.org/W1963654184","https://openalex.org/W1966933353","https://openalex.org/W1967445973","https://openalex.org/W1968258479","https://openalex.org/W1969088392","https://openalex.org/W1969241563","https://openalex.org/W1970276411","https://openalex.org/W1974110822","https://openalex.org/W1976241604","https://openalex.org/W1977656340","https://openalex.org/W1979412071","https://openalex.org/W1979548320","https://openalex.org/W1979706720","https://openalex.org/W1980958772","https://openalex.org/W1984132555","https://openalex.org/W1990195067","https://openalex.org/W1990693023","https://openalex.org/W1993441783","https://openalex.org/W1994365250","https://openalex.org/W1994583461","https://openalex.org/W1996918553","https://openalex.org/W1997773537","https://openalex.org/W2003870745","https://openalex.org/W2004861664","https://openalex.org/W2005219014","https://openalex.org/W2005805156","https://openalex.org/W2006543817","https://openalex.org/W2007659050","https://openalex.org/W2010677325","https://openalex.org/W2011856858","https://openalex.org/W2012437213","https://openalex.org/W2014186956","https://openalex.org/W2015738018","https://openalex.org/W2017071579","https://openalex.org/W2020345143","https://openalex.org/W2022971351","https://openalex.org/W2023562642","https://openalex.org/W2026394570","https://openalex.org/W2026920505","https://openalex.org/W2027133261","https://openalex.org/W2028417302","https://openalex.org/W2029773027","https://openalex.org/W2030192333","https://openalex.org/W2032082778","https://openalex.org/W2033987226","https://openalex.org/W2034302571","https://openalex.org/W2036784794","https://openalex.org/W2036836052","https://openalex.org/W2037088501","https://openalex.org/W2037880067","https://openalex.org/W2038603404","https://openalex.org/W2038681191","https://openalex.org/W2038718124","https://openalex.org/W2038803405","https://openalex.org/W2039278502","https://openalex.org/W2040054861","https://openalex.org/W2040755286","https://openalex.org/W2044120763","https://openalex.org/W2044445411","https://openalex.org/W2048099772","https://openalex.org/W2048142299","https://openalex.org/W2048770901","https://openalex.org/W2048788553","https://openalex.org/W2051053924","https://openalex.org/W2052701413","https://openalex.org/W2054160636","https://openalex.org/W2055804746","https://openalex.org/W2055961929","https://openalex.org/W2056448123","https://openalex.org/W2057727301","https://openalex.org/W2059499438","https://openalex.org/W2060884712","https://openalex.org/W2061028971","https://openalex.org/W2061093792","https://openalex.org/W2061228854","https://openalex.org/W2061257079","https://openalex.org/W2062024916","https://openalex.org/W2063120457","https://openalex.org/W2065618227","https://openalex.org/W2067205837","https://openalex.org/W2067448997","https://openalex.org/W2069411014","https://openalex.org/W2078015875","https://openalex.org/W2079749916","https://openalex.org/W2080428472","https://openalex.org/W2081903103","https://openalex.org/W2082250938","https://openalex.org/W2083708034","https://openalex.org/W2085652779","https://openalex.org/W2085929029","https://openalex.org/W2087609682","https://openalex.org/W2088811711","https://openalex.org/W2089744254","https://openalex.org/W2089895199","https://openalex.org/W2091759943","https://openalex.org/W2099496555","https://openalex.org/W2101181377","https://openalex.org/W2102016892","https://openalex.org/W2102991194","https://openalex.org/W2106814023","https://openalex.org/W2106918274","https://openalex.org/W2108064744","https://openalex.org/W2108809782","https://openalex.org/W2111380872","https://openalex.org/W2111602046","https://openalex.org/W2118366155","https://openalex.org/W2118849121","https://openalex.org/W2121268584","https://openalex.org/W2121281425","https://openalex.org/W2126402843","https://openalex.org/W2127040854","https://openalex.org/W2129055774","https://openalex.org/W2130044050","https://openalex.org/W2131228625","https://openalex.org/W2136182876","https://openalex.org/W2136679918","https://openalex.org/W2142796780","https://openalex.org/W2145977550","https://openalex.org/W2146220883","https://openalex.org/W2146355265","https://openalex.org/W2148444267","https://openalex.org/W2149498660","https://openalex.org/W2154541766","https://openalex.org/W2156309075","https://openalex.org/W2158628437","https://openalex.org/W2169315867","https://openalex.org/W2171593182","https://openalex.org/W2172006245"],"related_works":["https://openalex.org/W843601636","https://openalex.org/W4393403088","https://openalex.org/W2484649715","https://openalex.org/W2168634761","https://openalex.org/W7098613473","https://openalex.org/W2727071945","https://openalex.org/W3011025543","https://openalex.org/W1560323926","https://openalex.org/W4394626049","https://openalex.org/W7166922642"],"abstract_inverted_index":{"Le":[0,92],"glioblastome":[1],"multiforme":[2],"(GBM)":[3],"est":[4,21],"un":[5,13,52,67,83,213,280],"stade":[6],"avanc\u00e9":[7],"de":[8,17,28,33,71,94,112,136,152,154,175,185,194,209,215,233],"cancer":[9,89,276],"du":[10,58,77,90,101,275,290],"cerveau":[11],"avec":[12],"tr\u00e8s":[14],"faible":[15,246],"taux":[16],"survie.":[18],"Sa":[19],"r\u00e9currence":[20],"assez":[22],"fr\u00e9quente,":[23],"caus\u00e9e":[24],"par":[25,201,249,254,272],"la":[26,34,41,75,104,113,126,176,179,183,186,198,204,283],"pr\u00e9sence":[27],"cellules":[29,153,210,234,256],"tumorales":[30],"en":[31,140,247],"dehors":[32],"masse":[35],"primaire,":[36],"ce":[37],"qui":[38,163,241],"rend":[39],"difficile":[40],"r\u00e9section":[42],"chirurgicale.":[43],"Des":[44],"recherches":[45],"ant\u00e9rieures":[46],"dans":[47,74,87,103,149,197,212,218,265],"notre":[48],"laboratoire":[49],"ont":[50,131,164,242],"sugg\u00e9r\u00e9":[51],"lien":[53,281],"entre":[54,282],"le":[55,88,99,173],"pouvoir":[56],"envahissant":[57],"GBM":[59,270],"et":[60,79,169,182,287,292],"CRMP1":[61,102,291],"(Collapsin":[62],"Response":[63],"Mediator":[64],"Protein":[65],"1),":[66],"membre":[68],"d'une":[69],"famille":[70,114],"phosphoprot\u00e9ines":[72],"impliqu\u00e9es":[73],"dynamique":[76],"cytosquelette":[78],"d\u00e9j\u00e0":[80],"consid\u00e9r\u00e9":[81],"comme":[82],"g\u00e8ne":[84],"suppresseur":[85],"d\u2019invasion":[86],"poumon.":[91],"but":[93],"cette":[95],"\u00e9tude":[96],"\u00e9tait":[97],"d'examiner":[98],"r\u00f4le":[100],"migration":[105,180],"cellulaire":[106,181,200],"des":[107,144,160,239,255,261,268,285],"GBM.":[108],"Plusieurs":[109],"autres":[110],"membres":[111],"CRMP":[115,145],"ainsi":[116],"que":[117,299],"leurs":[118],"isoformes":[119],"\u00e9piss\u00e9es":[120],"differentiellement":[121],"(forme":[122],"longue":[123],"-":[124,129],"L,":[125],"forme":[127],"normale":[128],"S)":[130],"\u00e9galement":[132],"\u00e9t\u00e9":[133,147,165,243],"examin\u00e9s":[134],"afin":[135],"d\u00e9terminer":[137],"les":[138,150,219,228,266,288],"propri\u00e9t\u00e9s":[139],"commun.":[141],"L\u2019ADN":[142],"compl\u00e9mentaire":[143],"a":[146,203,237,278],"transfect\u00e9":[148],"lign\u00e9es":[151,220],"gliome":[155],"(U87,":[156],"U251N)":[157],"pour":[158],"g\u00e9n\u00e9rer":[159],"populations":[161],"stables":[162],"caract\u00e9ris\u00e9es":[166],"in":[167,170],"vitro":[168],"vivo":[171],"sur":[172],"plan":[174],"viabilit\u00e9":[177],"cellulaire,":[178],"croissance":[184],"tumeur.":[187],"Bien":[188],"qu'il":[189],"n'y":[190],"ait":[191],"pas":[192],"eu":[193],"diff\u00e9rence":[195],"significative":[196],"prolif\u00e9ration":[199],"rapport":[202,250],"lign\u00e9e":[205],"contr\u00f4le,":[206],"beaucoup":[207],"moins":[208],"migr\u00e8rent":[211],"essai":[214],"type":[216],"Boyden":[217],"surexprimant":[221,235],"soit":[222],"CRMP1-S,":[223],"CRMP2-S,":[224],"ou":[225],"CRMP4-S.":[226],"Dans":[227],"souris":[229],"thimopriv\u00e9es,":[230],"l'implantation":[231],"intrac\u00e9r\u00e9brale":[232],"CRMP1-S":[236],"produit":[238],"tumeurs":[240],"nettement":[244],"plus":[245],"volume":[248],"\u00e0":[251],"celles":[252],"produites":[253],"contr\u00f4les.":[257],"En":[258,294],"outre,":[259],"l'analyse":[260],"profils":[262],"d'expression":[263],"g\u00e9nique":[264],"\u00e9chantillons":[267],"patients":[269,286],"recueillis":[271],"l'Institut":[273],"national":[274],"(Rembrandt)":[277],"d\u00e9montr\u00e9":[279],"survie":[284],"niveaux":[289],"CRMP4.":[293],"conclusion,":[295],"nos":[296],"r\u00e9sultats":[297],"sugg\u00e8rent":[298],"CRMPs":[300],"1,":[301]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}