{"id":"https://openalex.org/W2182977374","doi":null,"title":"Anti-stress and nootropic activity of aqueous extract of Piper longum fruit, estimated by noninvasive biomarkers and Y-maze test in rodents","display_name":"Anti-stress and nootropic activity of aqueous extract of Piper longum fruit, estimated by noninvasive biomarkers and Y-maze test in rodents","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2182977374","mag":"2182977374"},"language":"en","primary_location":{"id":"mag:2182977374","doi":null,"is_oa":false,"landing_page_url":"http://eeb.lu.lv/EEB/201503/EEB_XII_1_Kilari.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036533491","display_name":"Eswar Kumar Kilari","orcid":"https://orcid.org/0000-0002-1182-5919","observed_orcids":["https://orcid.org/0000-0002-1182-5919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eswar Kumar Kilari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1182-5919","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033348815","display_name":"Lakshmi Sudeepthi Nissankara Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakshmi Sudeepthi Nissankara Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108350461","display_name":"Satyanarayana Sreemanthula","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satyanarayana Sreemanthula","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072572741","display_name":"Phani Kumar Kola","orcid":"https://orcid.org/0000-0002-1833-7811","observed_orcids":["https://orcid.org/0000-0002-1833-7811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phani Kumar Kola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1833-7811","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1716,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71477387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piper-longum","display_name":"Piper longum","score":1.0},{"id":"https://openalex.org/keywords/anti-stress-activity","display_name":"anti-stress activity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nootropic-activity","display_name":"nootropic activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/aqueous-fruit-extract","display_name":"aqueous fruit extract","score":0.8339999914169312},{"id":"https://openalex.org/keywords/forced-swim-stress","display_name":"forced swim stress","score":0.8679999709129333},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vanillylmandelic-acid","display_name":"vanillylmandelic acid","score":0.949999988079071},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9810000061988831},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9769999980926514},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9139999747276306},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.9049999713897705},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2776239663","wikidata":"https://www.wikidata.org/wiki/Q742487","display_name":"Nootropic","level":2,"score":0.8783923983573914},{"id":"https://openalex.org/C2777155639","wikidata":"https://www.wikidata.org/wiki/Q159536","display_name":"Piper","level":2,"score":0.6529116630554199},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5229402780532837},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5099905729293823},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.504630446434021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48528000712394714},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.35552793741226196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30936288833618164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2063761055469513}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182977374","doi":null,"is_oa":false,"landing_page_url":"http://eeb.lu.lv/EEB/201503/EEB_XII_1_Kilari.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1499552079","https://openalex.org/W1535426243","https://openalex.org/W1582872872","https://openalex.org/W1588415356","https://openalex.org/W1887418188","https://openalex.org/W1971991198","https://openalex.org/W1972602563","https://openalex.org/W1972706733","https://openalex.org/W1985031521","https://openalex.org/W2005708143","https://openalex.org/W2016184055","https://openalex.org/W2017219163","https://openalex.org/W2019741239","https://openalex.org/W2022832219","https://openalex.org/W2037058910","https://openalex.org/W2041053115","https://openalex.org/W2041110016","https://openalex.org/W2042207765","https://openalex.org/W2057340134","https://openalex.org/W2060951331","https://openalex.org/W2065965142","https://openalex.org/W2066419788","https://openalex.org/W2087491405","https://openalex.org/W2090724202","https://openalex.org/W2090918367","https://openalex.org/W2097363156","https://openalex.org/W2113965013","https://openalex.org/W2119360807","https://openalex.org/W2120504552","https://openalex.org/W2137512719","https://openalex.org/W2143302321","https://openalex.org/W2144101679","https://openalex.org/W2150164025","https://openalex.org/W2181947375","https://openalex.org/W2182427719","https://openalex.org/W2744406150","https://openalex.org/W4248359557"],"related_works":["https://openalex.org/W2073062847","https://openalex.org/W2747526697","https://openalex.org/W2204118574","https://openalex.org/W2193497130","https://openalex.org/W4389052123","https://openalex.org/W2187875222","https://openalex.org/W7098918956","https://openalex.org/W4293142491","https://openalex.org/W2953241911","https://openalex.org/W3206943597"],"abstract_inverted_index":{"Piper":[0],"longum":[1,51,89,119,131,162,208],"L.,":[2],"also":[3],"known":[4],"as":[5,75,94],"long":[6],"pepper":[7],"or":[8],"pipli,":[9],"belongs":[10],"to":[11,22,33,40,120,147,192],"family":[12],"Piperaceae.":[13],"Fruits":[14],"of":[15,26,49,84,87,116,126,129,134,149,175,197,206],"this":[16,198],"plant":[17],"have":[18],"been":[19],"used":[20],"traditionally":[21],"treat":[23],"a":[24,102,158],"variety":[25],"diseases.":[27],"The":[28,105,195],"current":[29],"study":[30,199],"was":[31,110],"done":[32],"evaluate":[34],"anti-stress":[35,201],"activity":[36,82,109,188,204],"in":[37,70,99,101,106,157,168,172,209],"rats":[38,100,176],"subjected":[39],"forced":[41],"swim":[42],"stress":[43,150],"one":[44,144],"hour":[45,145],"after":[46,178],"daily":[47],"treatment":[48,163],"P.":[50,88,118,130,161,207],"extract.":[52],"Urinary":[53],"vanillylmandellic":[54],"acid,":[55,57,63],"5-hydroxyindoleacetic":[56],"homo":[58],"vanillic":[59],"acid":[60],"and":[61,67,80,96,137,186,202],"ascorbic":[62],"estimated":[64,93],"by":[65,183],"HPLC":[66],"spectrophotometric":[68],"methods":[69],"all":[71],"groups,":[72],"were":[73,92,190],"selected":[74],"non":[76],"invasive":[77],"biomarkers.":[78],"Anti-stress":[79],"nootropic":[81,203],"activities":[83],"aqueous":[85,127],"extract":[86,91,128],"fruit":[90],"locomotor":[95,187],"working":[97,184],"memory":[98,185],"Y-maze":[103],"apparatus.":[104],"vitro":[107],"antioxidant":[108],"determined":[111,182],"based":[112],"on":[113],"the":[114,117,152],"ability":[115],"scavenge":[121],"free":[122],"radicals.":[123],"Daily":[124],"administration":[125],"at":[132],"doses":[133],"100,":[135],"200":[136],"300":[138],"mg":[139],"per":[140],"kg":[141],"body":[142],"weight":[143],"prior":[146],"induction":[148],"increased":[151],"stress-induced":[153],"urinary":[154],"biomarker":[155,170],"levels":[156,171],"dose-dependent":[159,166],"manner.":[160],"showed":[164],"significant":[165],"variation":[167],"non-invasive":[169],"urine":[173],"samples":[174],"taken":[177],"24":[179],"h.":[180],"Cognition,":[181],"results,":[189],"shown":[191],"be":[193],"dose-dependent.":[194],"results":[196],"suggest":[200],"effect":[205],"rodents.":[210]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}