{"id":"https://openalex.org/W2182957769","doi":null,"title":"Effects of rIFN-beta-1b on serum circulating ICAM-1 in relapsing remitting multiple sclerosis and on the membrane-bound ICAM-1 expression on brain microvascular endothelial cells.","display_name":"Effects of rIFN-beta-1b on serum circulating ICAM-1 in relapsing remitting multiple sclerosis and on the membrane-bound ICAM-1 expression on brain microvascular endothelial cells.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2182957769","mag":"2182957769","pmid":"https://pubmed.ncbi.nlm.nih.gov/10871785"},"language":"en","primary_location":{"id":"pmid:10871785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023725739","display_name":"Mar\u00eda Trojano","orcid":"https://orcid.org/0000-0002-6329-8946","observed_orcids":["https://orcid.org/0000-0002-6329-8946"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Trojano","raw_affiliation_strings":["Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009537758","display_name":"Giovanni Defazio","orcid":"https://orcid.org/0000-0002-8221-439X","observed_orcids":["https://orcid.org/0000-0002-8221-439X","https://orcid.org/0000-0001-5950-3110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Defazio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024279876","display_name":"Carlo Avolio","orcid":"https://orcid.org/0000-0002-0987-1967","observed_orcids":["https://orcid.org/0000-0002-0987-1967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Avolio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061592086","display_name":"Damiano Paolicelli","orcid":"https://orcid.org/0000-0002-8645-1763","observed_orcids":["https://orcid.org/0000-0002-8645-1763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Paolicelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079991612","display_name":"Fabrizio Giuliani","orcid":"https://orcid.org/0000-0002-4042-8533","observed_orcids":["https://orcid.org/0000-0002-4042-8533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Giuliani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027343141","display_name":"Maurizio Giorelli","orcid":"https://orcid.org/0000-0001-6069-7063","observed_orcids":["https://orcid.org/0000-0001-6069-7063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Giorelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076090392","display_name":"Paolo Livrea","orcid":"https://orcid.org/0000-0001-7410-3860","observed_orcids":["https://orcid.org/0000-0001-7410-3860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Livrea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5561,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81330432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6 Suppl 2","issue":null,"first_page":"S47","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta-1b","display_name":"interferon beta-1b","score":0.9290000200271606},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/soluble-icam-1","display_name":"soluble ICAM-1","score":0.847000002861023},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.668563961982727},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6335780620574951},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.575455904006958},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5700684189796448},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5660018920898438},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5631893277168274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.528542697429657},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49796319007873535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4624815881252289},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4476194679737091},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4390047788619995},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.43582040071487427},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42817527055740356},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3362048268318176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32375913858413696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22362631559371948},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17221176624298096},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15492767095565796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14122357964515686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1343827247619629},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068576","descriptor_name":"Interferon beta-1b","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005682","descriptor_name":"Gadolinium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:10871785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.415.834","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.415.834","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurovirol.com/pdf/6(s2)/s47-s51.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unica.it:11584/235040","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/235040","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/127295","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/127295","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2182957769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1495679080","https://openalex.org/W1965770390","https://openalex.org/W1997878733","https://openalex.org/W2002597831","https://openalex.org/W2023437720","https://openalex.org/W2044173905","https://openalex.org/W2046368251","https://openalex.org/W2054132514","https://openalex.org/W2075705190","https://openalex.org/W2083770877","https://openalex.org/W2089424886","https://openalex.org/W2095330294","https://openalex.org/W2103931528","https://openalex.org/W2112165124","https://openalex.org/W2123226439","https://openalex.org/W2130355701","https://openalex.org/W2139367012","https://openalex.org/W2165547142","https://openalex.org/W2169098250","https://openalex.org/W2246548868","https://openalex.org/W2340533542"],"related_works":["https://openalex.org/W7098637892","https://openalex.org/W7019156713","https://openalex.org/W2124795017","https://openalex.org/W2063095606","https://openalex.org/W7036515050","https://openalex.org/W2012748572","https://openalex.org/W7008578511","https://openalex.org/W2020530458","https://openalex.org/W2044173905","https://openalex.org/W2023437720"],"abstract_inverted_index":{"rIFN-beta":[0,57],"reduces":[1],"the":[2,5,24,27,35,40,63,107,111,113,117,136,149,167,196,230,235],"frequency":[3],"of":[4,20,26,37,95,110,119,141,156,169,175,188,201,206,232],"gadolinium-enhancing":[6],"(Gd+)":[7],"magnetic":[8],"resonance":[9],"imaging":[10],"(MRI)":[11],"lesions":[12],"in":[13,49,92,135,148,242],"relapsing":[14],"remitting":[15],"(RR)":[16],"MS.":[17],"Its":[18],"mechanism":[19],"action":[21],"on":[22,39,71,234],"improving":[23],"integrity":[25],"blood-brain":[28],"barrier":[29],"(BBB)":[30],"remains":[31],"unclear.":[32],"We":[33],"investigated":[34],"effect":[36,231],"rIFN-beta-1b":[38,96,189,207,233],"soluble":[41],"intercellular":[42],"adhesion":[43],"molecule-1":[44],"(sICAM-1)":[45],"serum":[46,85,245],"levels":[47,86,246],"(ELISA)":[48],"36":[50],"RR":[51],"MS":[52],"patients":[53,142],"receiving":[54],"treatment":[55,112,157],"with":[56,143,172,203],"for":[58,177,190,208,217],"1":[59],"year,":[60],"and":[61,103,152,215,247],"also":[62],"TNF-alpha":[64,176,216],"-":[65],"induced":[66],"membrane-bound":[67],"ICAM-1":[68],"(mICAM-1)":[69],"expression":[70],"cultured":[72],"rat":[73],"brain":[74],"microvascular":[75],"endothelial":[76],"cells":[77],"(BMECs).":[78],"In":[79,106,162],"vivo":[80],"data":[81],"showed":[82,165],"that":[83,166,229],"sICAM-1":[84,244],"at":[87],"baseline":[88,127,160,197],"significantly":[89,131,146,180,220],"increased":[90,182],"(P<0.01)":[91],"12":[93],"months":[94],"treatment.":[97],"The":[98,139,199],"increase":[99],"paralleled":[100],"a":[101],"clinical":[102],"MRI":[104],"improvement.":[105],"second":[108,153],"semester":[109],"integrated":[114],"area":[115],"under":[116],"curve":[118],"Expanded":[120],"Disability":[121],"Status":[122],"Score":[123],"normalised":[124],"to":[125,159],"entry":[126],"(DeltaEDSS":[128],"AUC)":[129],"was":[130],"(P<0.05)":[132,147,181,221],"smaller":[133],"than":[134],"first":[137,150],"semester.":[138],"percentage":[140],"Gd+MRI":[144],"decreased":[145],"(33%)":[151],"(29%)":[154],"semesters":[155],"compared":[158],"(62%).":[161],"vitro":[163],"experiments":[164],"incubation":[168,200],"BMEC":[170,202,249],"monolayer":[171],"100":[173],"u/ml":[174,187,205],"24":[178,218],"h":[179,192,210,219],"mICAM-1":[183,224,248],"expression,":[184],"whereas":[185],"2000":[186,204],"72":[191],"did":[193],"not":[194],"modify":[195],"levels.":[198],"48":[209],"followed":[211],"by":[212,240],"combined":[213],"IFN-beta-1b":[214],"downregulated":[222],"TNF-alpha-induced":[223],"expression.":[225,250],"These":[226],"results":[227],"suggest":[228],"BBB":[236],"may":[237],"be":[238],"mediated":[239],"changes":[241],"both":[243]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
