{"id":"https://openalex.org/W2182944285","doi":"https://doi.org/10.1016/s0022-2275(20)41196-4","title":"13C NMR studies of the binding of medium-chain fatty acids to human serum albumin.","display_name":"13C NMR studies of the binding of medium-chain fatty acids to human serum albumin.","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W2182944285","doi":"https://doi.org/10.1016/s0022-2275(20)41196-4","mag":"2182944285","pmid":"https://pubmed.ncbi.nlm.nih.gov/8014580"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)41196-4","doi":"https://doi.org/10.1016/s0022-2275(20)41196-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)41196-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-2275(20)41196-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098044382","display_name":"M A Kenyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Kenyon","raw_affiliation_strings":["Department of Biophysics, Housman Research Center, Boston University Medical School, 80 E. Concord Street, Rill, Boston, MA 02118-2394"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Housman Research Center, Boston University Medical School, 80 E. Concord Street, Rill, Boston, MA 02118-2394","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028209802","display_name":"James A. Hamilton","orcid":"https://orcid.org/0000-0002-4747-7071","observed_orcids":["https://orcid.org/0000-0002-4747-7071"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Hamilton","raw_affiliation_strings":["Department of Biophysics, Housman Research Center, Boston University Medical School, 80 E. Concord Street, Rill, Boston, MA 02118-2394"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Housman Research Center, Boston University Medical School, 80 E. Concord Street, Rill, Boston, MA 02118-2394","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.7594,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.69597322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"3","first_page":"458","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medium-chain-fatty-acids","display_name":"medium-chain fatty acids","score":0.921999990940094},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/fatty-acid-binding","display_name":"fatty acid binding","score":0.7419999837875366},{"id":"https://openalex.org/keywords/octanoic-acid","display_name":"octanoic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/decanoic-acid","display_name":"capric acid","score":1.0},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.8899999856948853},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6159999966621399},{"id":"https://openalex.org/keywords/carboxylate-binding","display_name":"carboxylate binding","score":0.5889999866485596},{"id":"https://openalex.org/keywords/binding-site-heterogeneity","display_name":"binding site heterogeneity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.4189999997615814},{"id":"https://openalex.org/keywords/medium-chain-triglycerides","display_name":"medium-chain triglycerides","score":0.6949999928474426},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6484519839286804},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5559007525444031},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.5200538039207458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4875170886516571},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.45568230748176575}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003652","descriptor_name":"Decanoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)41196-4","doi":"https://doi.org/10.1016/s0022-2275(20)41196-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)41196-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:8014580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8014580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a5a30243150b4082adce5ff9ccf0aebb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a5a30243150b4082adce5ff9ccf0aebb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 35, Iss 3, Pp 458-467 (1994)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)41196-4","doi":"https://doi.org/10.1016/s0022-2275(20)41196-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)41196-4","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.550000011920929}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6048144797","display_name":"Structural and Cell Biology in Cardiovascular Disease","funder_award_id":"P01HL026335","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8324525755","display_name":null,"funder_award_id":"HL26335","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W4390707","https://openalex.org/W146682915","https://openalex.org/W172004573","https://openalex.org/W187776620","https://openalex.org/W1220159786","https://openalex.org/W1417221091","https://openalex.org/W1526532732","https://openalex.org/W1535350863","https://openalex.org/W1544208135","https://openalex.org/W1544339897","https://openalex.org/W1560376606","https://openalex.org/W1574451580","https://openalex.org/W1575542562","https://openalex.org/W1795298952","https://openalex.org/W1927899726","https://openalex.org/W1972647870","https://openalex.org/W1973238993","https://openalex.org/W1982263155","https://openalex.org/W1983095597","https://openalex.org/W1994945417","https://openalex.org/W2014550271","https://openalex.org/W2017215225","https://openalex.org/W2029554708","https://openalex.org/W2029856935","https://openalex.org/W2040580509","https://openalex.org/W2056377090","https://openalex.org/W2057004091","https://openalex.org/W2065906407","https://openalex.org/W2068760317","https://openalex.org/W2074774697","https://openalex.org/W2082417994","https://openalex.org/W2086405274","https://openalex.org/W2092114529","https://openalex.org/W2109879785","https://openalex.org/W2129976402","https://openalex.org/W2247993598","https://openalex.org/W2284746773","https://openalex.org/W2314066650","https://openalex.org/W2394660565","https://openalex.org/W6671303111"],"related_works":["https://openalex.org/W1560376606","https://openalex.org/W2063907999","https://openalex.org/W2073068322","https://openalex.org/W2524689808","https://openalex.org/W1544339897","https://openalex.org/W172004573","https://openalex.org/W2090427843","https://openalex.org/W2157438880","https://openalex.org/W2493296989","https://openalex.org/W2017215225"],"abstract_inverted_index":{"Binding":[0],"of":[1,58,74,84,88,108,125,144,156,175,196],"the":[2,42,55,153,157,172,183],"medium-chain":[3],"fatty":[4,149,158],"acids":[5],"(MCFA),":[6],"octanoic":[7],"(OCT)":[8],"and":[9,50,64,76,79,137,177],"decanoic":[10],"(DEC)":[11],"acid,":[12],"to":[13,114,120,142,161,182,188],"human":[14],"serum":[15],"albumin":[16],"(HSA)":[17],"has":[18,202],"been":[19],"studied":[20],"by":[21],"13C":[22],"NMR":[23,25],"spectroscopy.":[24],"spectra":[26],"at":[27,46,91,96,110],"35":[28,115],"degrees":[29,93,116],"C":[30,94],"showed":[31,170],"an":[32],"apparently":[33],"homogeneous":[34],"binding":[35,100,109,128,145,200],"environment":[36],"(a":[37],"single,":[38],"narrow":[39],"resonance":[40],"for":[41,134,147,204],"13C-enriched":[43],"carboxyl":[44],"carbon)":[45],"different":[47,189],"mole":[48,62,174],"ratios":[49],"pH":[51],"values.":[52],"Changes":[53],"in":[54],"chemical":[56,167],"shift":[57,168],"this":[59],"peak":[60],"with":[61,207],"ratio":[63],"protein":[65],"concentration":[66],"demonstrated":[67],"rapid":[68,194],"equilibration":[69],"(<":[70],"or":[71,186],"=":[72],"msec)":[73],"bound":[75],"unbound":[77],"MCFA":[78,197],"permitted":[80],"a":[81,121],"direct":[82],"quantitation":[83],"bound/unbound":[85],"MCFA.":[86],"Spectra":[87],"OCT/HSA":[89],"mixtures":[90],"6":[92],"revealed":[95],"least":[97],"three":[98],"distinct":[99],"sites":[101,133,146,190,201],"that":[102,171],"fill":[103],"sequentially.":[104],"The":[105,130,193],"observed":[106],"heterogeneity":[107],"low":[111],"temperature,":[112],"compared":[113],"C,":[117],"is":[118],"attributed":[119],"slower":[122],"exchange":[123],"rate":[124],"OCT":[126,136,176],"between":[127],"sites.":[129],"highest":[131],"affinity":[132],"both":[135],"DEC":[138,178],"have":[139],"properties":[140],"similar":[141],"those":[143],"longer-chain":[148],"acids,":[150],"such":[151],"as":[152],"close":[154],"proximity":[155],"acid":[159,164],"carboxylate":[160],"basic":[162],"amino":[163],"residue(s).":[165],"Interestingly,":[166],"data":[169],"first":[173],"either":[179],"bind":[180,187],"differently":[181],"same":[184],"site":[185],"on":[191],"HSA.":[192],"desorption":[195],"from":[198],"HSA":[199],"implications":[203],"dietary":[205],"regimens":[206],"medium":[208],"chain":[209],"triglycerols.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
