{"id":"https://openalex.org/W2182915560","doi":null,"title":"ABCB's in a coastal bivalve: characterization, evolutionary insights and the potential use for biomonitoring","display_name":"ABCB's in a coastal bivalve: characterization, evolutionary insights and the potential use for biomonitoring","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2182915560","mag":"2182915560"},"language":"en","primary_location":{"id":"mag:2182915560","doi":null,"is_oa":false,"landing_page_url":"http://primage.tau.ac.il/libraries/theses/lifemed/free/2132500.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089084179","display_name":"Tamar Feldstein\u2010Farkash","orcid":"https://orcid.org/0009-0007-9277-1417","observed_orcids":["https://orcid.org/0009-0007-9277-1417"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tamar Feldstein\u2010Farkash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089084179"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.25200000405311584,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11088","display_name":"Marine Bivalve and Aquaculture Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abcb-transporters","display_name":"ABCB transporters","score":0.7910000085830688},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8330000042915344},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.718999981880188},{"id":"https://openalex.org/keywords/brachidontes-pharaonis","display_name":"Brachidontes pharaonis","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.6759999990463257},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5239999890327454},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4869999885559082},{"id":"https://openalex.org/keywords/pollution-monitoring","display_name":"pollution monitoring","score":0.777999997138977},{"id":"https://openalex.org/keywords/coastal-marine-pollution","display_name":"coastal marine pollution","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.5479999780654907},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mollusca","display_name":"Mollusca","score":0.46299999952316284},{"id":"https://openalex.org/keywords/israeli-coast","display_name":"Mediterranean coast of Israel","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C109051061","wikidata":"https://www.wikidata.org/wiki/Q864610","display_name":"Biomonitoring","level":2,"score":0.7880709171295166},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.41326162219047546},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.38017112016677856},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3418530225753784},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.3355264663696289},{"id":"https://openalex.org/C107826830","wikidata":"https://www.wikidata.org/wiki/Q929380","display_name":"Environmental resource management","level":1,"score":0.3298186659812927},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3066316843032837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2915746569633484},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1395772397518158},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182915560","doi":null,"is_oa":false,"landing_page_url":"http://primage.tau.ac.il/libraries/theses/lifemed/free/2132500.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":155,"referenced_works":["https://openalex.org/W84386476","https://openalex.org/W124504601","https://openalex.org/W149315073","https://openalex.org/W152057668","https://openalex.org/W583594335","https://openalex.org/W1504187995","https://openalex.org/W1517172122","https://openalex.org/W1522783390","https://openalex.org/W1528256008","https://openalex.org/W1529837192","https://openalex.org/W1551279498","https://openalex.org/W1558851509","https://openalex.org/W1565131375","https://openalex.org/W1577612357","https://openalex.org/W1587030064","https://openalex.org/W1590384320","https://openalex.org/W1600070587","https://openalex.org/W1647733608","https://openalex.org/W1647833960","https://openalex.org/W1737567770","https://openalex.org/W1818204911","https://openalex.org/W1874748829","https://openalex.org/W1964954849","https://openalex.org/W1968733465","https://openalex.org/W1968931590","https://openalex.org/W1973751291","https://openalex.org/W1980322569","https://openalex.org/W1982542571","https://openalex.org/W1982590245","https://openalex.org/W1986537087","https://openalex.org/W1986654525","https://openalex.org/W1990456014","https://openalex.org/W1991766268","https://openalex.org/W1995984403","https://openalex.org/W1996511356","https://openalex.org/W1996709055","https://openalex.org/W1997204305","https://openalex.org/W1998778411","https://openalex.org/W1998859054","https://openalex.org/W1998871765","https://openalex.org/W2002447755","https://openalex.org/W2003605043","https://openalex.org/W2005160619","https://openalex.org/W2005416094","https://openalex.org/W2006700952","https://openalex.org/W2007931369","https://openalex.org/W2010648165","https://openalex.org/W2010824798","https://openalex.org/W2012902933","https://openalex.org/W2012984166","https://openalex.org/W2013277487","https://openalex.org/W2014691271","https://openalex.org/W2015073801","https://openalex.org/W2015800304","https://openalex.org/W2017671389","https://openalex.org/W2019943022","https://openalex.org/W2020382742","https://openalex.org/W2021472730","https://openalex.org/W2021785773","https://openalex.org/W2028533496","https://openalex.org/W2028858498","https://openalex.org/W2028909107","https://openalex.org/W2032061892","https://openalex.org/W2032112450","https://openalex.org/W2032603300","https://openalex.org/W2033578182","https://openalex.org/W2037103758","https://openalex.org/W2037302753","https://openalex.org/W2046460191","https://openalex.org/W2046826691","https://openalex.org/W2047361910","https://openalex.org/W2047550476","https://openalex.org/W2048245347","https://openalex.org/W2050390330","https://openalex.org/W2050829866","https://openalex.org/W2051003270","https://openalex.org/W2053265284","https://openalex.org/W2053395211","https://openalex.org/W2054481420","https://openalex.org/W2057226689","https://openalex.org/W2058052390","https://openalex.org/W2058610280","https://openalex.org/W2058668911","https://openalex.org/W2061078854","https://openalex.org/W2061256841","https://openalex.org/W2061569374","https://openalex.org/W2061752537","https://openalex.org/W2063341211","https://openalex.org/W2063859006","https://openalex.org/W2064827806","https://openalex.org/W2065671653","https://openalex.org/W2067456291","https://openalex.org/W2068538944","https://openalex.org/W2069789404","https://openalex.org/W2070547060","https://openalex.org/W2071025146","https://openalex.org/W2071485403","https://openalex.org/W2075984523","https://openalex.org/W2077822514","https://openalex.org/W2078126583","https://openalex.org/W2079191979","https://openalex.org/W2088197374","https://openalex.org/W2088759826","https://openalex.org/W2089981039","https://openalex.org/W2094586317","https://openalex.org/W2095095292","https://openalex.org/W2097382368","https://openalex.org/W2097677316","https://openalex.org/W2100837269","https://openalex.org/W2102744264","https://openalex.org/W2103546861","https://openalex.org/W2105235828","https://openalex.org/W2108104463","https://openalex.org/W2111823557","https://openalex.org/W2116278022","https://openalex.org/W2118130027","https://openalex.org/W2118234018","https://openalex.org/W2119468178","https://openalex.org/W2122139213","https://openalex.org/W2122744278","https://openalex.org/W2123438212","https://openalex.org/W2124656134","https://openalex.org/W2125165687","https://openalex.org/W2127195733","https://openalex.org/W2131067627","https://openalex.org/W2134153749","https://openalex.org/W2135667467","https://openalex.org/W2136728676","https://openalex.org/W2138198587","https://openalex.org/W2142090471","https://openalex.org/W2144714567","https://openalex.org/W2147403657","https://openalex.org/W2147807123","https://openalex.org/W2150999890","https://openalex.org/W2152929241","https://openalex.org/W2153712534","https://openalex.org/W2155140832","https://openalex.org/W2155606054","https://openalex.org/W2156280292","https://openalex.org/W2157210385","https://openalex.org/W2158714788","https://openalex.org/W2164257406","https://openalex.org/W2169992673","https://openalex.org/W2170734806","https://openalex.org/W2192517678","https://openalex.org/W2207828069","https://openalex.org/W2241508192","https://openalex.org/W2315607028","https://openalex.org/W2327300465","https://openalex.org/W2416393929","https://openalex.org/W2471166493","https://openalex.org/W2494157096","https://openalex.org/W2615749116","https://openalex.org/W3174321755","https://openalex.org/W4251040559"],"related_works":["https://openalex.org/W2063341211","https://openalex.org/W2211795084","https://openalex.org/W1551250141","https://openalex.org/W4319936821","https://openalex.org/W7204945795","https://openalex.org/W2123646239","https://openalex.org/W1977089694","https://openalex.org/W3009695120","https://openalex.org/W3152589849","https://openalex.org/W2582109398"],"abstract_inverted_index":{"My":[0],"Ph.D.":[1],"research":[2,105,213,569,593],"concentrated":[3,219,1064],"on":[4,30,117,214,220,254,261,416,594,766,1065,1220,1438],"cloning":[5,34],"and":[6,38,135,197,206,260,282,308,396,430,449,494,497,526,544,547,585,608,730,769,797,872,960,986,995,1098,1115,1231,1324,1341],"characterizing":[7],"genes":[8,37,256,319,335,530,978,1029,1267],"which":[9,96,324,368,443,455,514,670,751,911,990,996,1014,1052],"belong":[10],"to":[11,53,156,170,173,285,303,353,381,406,411,471,488,524,625,651,681,778,807,902,1038,1083,1127,1145,1175,1252,1254,1278,1298,1321,1338,1389,1412,1419],"the":[12,17,36,40,46,51,55,59,74,86,104,107,118,124,165,183,209,212,236,255,270,274,279,317,331,347,382,389,407,412,424,438,450,464,473,476,481,512,518,532,542,550,554,565,580,626,636,643,659,665,676,694,710,735,747,753,756,761,767,780,794,798,809,813,817,821,830,866,875,881,890,903,925,953,969,982,1006,1047,1073,1131,1146,1153,1173,1184,1190,1202,1221,1227,1229,1234,1239,1256,1260,1282,1289,1322,1352,1356,1387,1404,1439],"ABCB":[13,78,292,318,360,401,519,529,653,714,827,892,942,962,1013,1262,1327,1339,1361],"protein":[14,128,230,242,639,782,863,1099,1235],"family":[15,1363],"from":[16,91,123,133,480,511,531,596,642,655,709,718,908,968,979,1263],"marine":[18,76,113,184,217,1090,1107],"bivalve":[19,533,623,958,1074,1248,1283],"Brachidontes":[20,534,1442],"pharaonis.":[21,535,1076],"The":[22,144,159,419,461,638,850,884,920,974,1021,1058,1077,1314,1428],"first":[23,147],"part":[24,48,1060],"of":[25,35,58,88,103,106,109,142,162,175,222,238,296,316,326,367,391,423,567,583,658,664,669,675,693,760,771,816,823,832,852,868,877,886,893,905,922,941,976,1008,1012,1023,1034,1061,1068,1079,1112,1172,1186,1192,1206,1233,1259,1311,1326,1358,1450],"my":[26,1062],"work":[27,1063,1319],"was":[28,146,167,266,467,522,538,562,614,679,716,776,789,803,950,965,1015,1082,1139,1166,1224,1243,1365,1398,1401,1431],"focused":[29,116],"basic":[31],"aspects,":[32],"including":[33],"utilizing":[39],"sequences":[41,466,640,654,759,783,834],"for":[42,70,154,178,247,321,374,458,501,517,689,726,858,862,1088,1103,1141,1395,1424,1433,1447],"evolutionary":[43],"analyses.":[44,741],"In":[45,268,620,805,1215,1250,1384],"second":[47,351,713,1059],"I":[49,521,671,819],"examined":[50,1167],"possibility":[52,1388],"use":[54,779],"expression":[56,189,231,243,263,879,1100,1160,1223,1230,1304,1393,1406],"levels":[57,1111,1394],"gene":[60,686,698,715,724,878,959],"coding":[61,257,677,861],"an":[62,946,961,1009,1303,1380],"ABCB1":[63,909],"in":[64,73,85,95,112,130,149,182,190,204,216,264,273,330,346,364,388,446,469,492,506,541,553,575,588,605,611,617,700,721,739,784,812,848,865,874,889,915,924,936,956,999,1019,1050,1072,1106,1118,1122,1125,1134,1152,1168,1178,1195,1208,1238,1246,1288,1296,1317,1329,1348,1368],"this":[65,568,597,612,622,957,1169,1318,1349,1385],"mussel":[66,537,613],"as":[67,244,486,498,564,1036,1101,1161,1242,1421],"a":[68,139,245,283,287,337,343,350,355,683,727,837,1031,1085,1162,1212,1217,1271,1359,1422],"biomarker":[69,246,1165,1423],"monitoring":[71,289,1396,1425],"pollution":[72,203,1397],"coastal":[75],"environment.":[77,1155],"proteins":[79,474,491,1284,1328,1340,1377],"are":[80,98,294,379,403,437,444,515,846,997],"membrane-bound":[81],"transporters":[82,111,293,378,402,818,910],"that":[83,341,600,631,687,705,842,897,964,1027,1275,1343,1364,1375,1403,1430],"function":[84,129,387],"export":[87,390,706],"various":[89,392,1279],"molecules":[90,708],"cells":[92,166],"or":[93,228,410],"oraganelles":[94],"they":[97,386,601],"expressed.":[99],"A":[100,440,712],"vast":[101],"portion":[102],"activity":[108,224,610,1097,1114,1232],"these":[110,258,785,898,1080,1135,1266,1376],"invertebrates":[114],"have":[115,991,1053],"multidrug":[119],"resistance":[120,155,201,914],"transporter":[121,685,729],"(MDR)":[122],"sub-family":[125],"ABCB1.":[126],"This":[127,536,697,723,1045,1372],"excluding":[131],"toxins":[132],"cells,":[134],"is":[136,192,426,456,572,632,835,840,1043,1276,1407,1415],"typified":[137],"by":[138,194,1410],"wide":[140],"range":[141],"substrates.":[143],"MDR":[145,188,215,223,241,609,1069,1095,1113,1116,1158,1187,1391],"discovered":[148],"tumor":[150],"cell":[151],"lines":[152],"selected":[153],"chemotherapeutic":[157],"drugs.":[158,1280],"reduced":[160],"accumulation":[161],"drugs":[163],"within":[164],"subsequently":[168],"found":[169,680,951,1402],"be":[171,682,856,1294,1445],"due":[172,1144],"over-expression":[174],"P-glycoprotein":[176],"responsible":[177],"MDR.":[179],"Ecological":[180],"studies":[181,1093],"environment":[185],"investigated":[186,272],"whether":[187],"molluscs":[191,218,265,1028,1119],"induced":[193,1183,1409],"organic":[195,1176],"pollutants,":[196,1413],"if":[198],"it":[199,571,839],"confers":[200],"against":[202],"bivalves":[205,1174],"gastropods.":[207],"Until":[208],"present":[210,445],"work,":[211],"measurements":[221,1067,1191],"using":[225,239,746,1157],"fluorescent":[226],"substrates":[227],"measuring":[229],"with":[232,235,301,349,703,734,1336],"universal":[233],"antibodies,":[234],"aim":[237],"elevated":[240,1204],"environmental":[248,1104],"pollution.":[249,1091],"However,":[250],"very":[251],"little":[252,791],"information":[253,810,1335],"transporters,":[259],"mRNA":[262,1193,1207,1222,1392,1405,1435],"available.":[267],"addition,":[269,621,1216],"species":[271,1441],"past":[275],"do":[276],"not":[277,932,1016,1200,1345,1416],"inhabit":[278],"Israeli":[280],"coast":[281,582],"need":[284],"develop":[286,1084],"local":[288,1440],"system":[290,1306],"arose.":[291],"composed":[295],"two":[297,309,528,644,977],"transmembrane":[298],"domains":[299,313],"(TMD)":[300],"five":[302],"six":[304],"\u03b1":[305],"helices":[306],"each,":[307],"cytosolic":[310],"nucleotide":[311],"binding":[312],"(NBD).":[314],"Some":[315],"code":[320,336,373],"\u2018full":[322],"transporters\u2019":[323],"comprise":[325],"all":[327,690],"four":[328,660,691],"subunits,":[329,764,796],"order":[332,470,806,1251,1297],"TMD-NBD-TMD-NBD.":[333],"Other":[334],"\u2018half":[338],"transporter\u2019":[339],"(TMD-NBD)":[340],"forms":[342],"homoor":[344],"hetero-dimer":[345],"membrane":[348,384,409],"\u2018half\u2019":[352,728,928],"create":[354],"\u2018full\u2019,":[356],"functional,":[357],"transporter.":[358,696],"Eleven":[359],"subfamilies":[361],"were":[362,483,649,744,1120,1236,1268,1285,1344],"described":[363],"humans,":[365],"three":[366,432],"ABCB1,":[369],"4":[370],"&":[371,441],"11":[372],"full":[375],"transporters.":[376,944],"These":[377,436,742,1331],"localized":[380],"cellular":[383,408],"where":[385,1040],"lipophilic":[393],"molecules,":[394],"phosphatidilcholine":[395],"bile":[397],"salts,":[398],"respectively.":[399],"Half":[400],"targeted":[404],"either":[405],"mitochondria":[413],"membrane,":[414],"depending":[415],"their":[417,606,1000],"function.":[418,1383],"amino":[420,757,772,1002],"acid":[421,758,773,1003],"sequence":[422,452,509,963,1334],"NBD":[425,465,482],"conserved":[427,434,847],"across":[428],"phyla,":[429],"contains":[431],"highly":[433],"motifs.":[435],"Walker":[439],"B":[442],"any":[447,937],"ATPase,":[448],"C-signature":[451],"(\u2018Walker":[453],"C\u2019)":[454],"unique":[457],"ABC":[459,490,504],"proteins.":[460,1301],"similarity":[462,792],"between":[463,755,793,801,825,952,1149],"used":[468,485,1094],"assign":[472],"into":[475,1270],"different":[477,656,826],"subfamilies.":[478],"Sequences":[479],"also":[484,873,1025,1366],"probes":[487],"identify":[489],"DNA":[493],"RNA":[495],"blots":[496],"priming":[499],"sites":[500,1124],"amplifying":[502],"new":[503,870,1086,1261],"fragments":[505],"PCR.":[507],"Using":[508],"identifiers":[510],"NBD,":[513],"specific":[516],"family,":[520],"able":[523],"amplify":[525],"clone":[527],"originally":[539],"distributed":[540],"Pacific":[543],"Indian":[545],"oceans,":[546],"has":[548],"invaded":[549],"Mediterranean":[551,581],"Sea":[552],"last":[555],"decade":[556],"through":[557],"human-mediated":[558],"processes.":[559],"B.":[560,645,666,719,894,926,1075,1264],"pharaonis":[561,646,667,720,895,927],"chosen":[563],"subject":[566],"because":[570],"well":[573],"established":[574],"rocky":[576],"intertidal":[577],"habitats":[578],"along":[579],"Israel":[584],"can":[586,602],"survive":[587],"extreme":[589],"chemical-physical":[590],"conditions.":[591],"Previous":[592,1092],"mussels":[595],"genus":[598],"demonstrated":[599],"accumulate":[603],"pollutants":[604,1177],"tissues,":[607],"observed":[615],"before":[616,1245,1347],"our":[618],"laboratory.":[619],"belongs":[624],"Mytilidae,":[627],"like":[628],"Mytilus":[629],"Sp.":[630],"extensively":[633],"studied":[634],"throughout":[635],"world.":[637],"translated":[641],"cloned":[647,672,717],"genes,":[648,668,871],"compared":[650,820],"known":[652,939],"representatives":[657],"biological":[661],"kingdoms.":[662],"One":[663],"about":[673],"85%":[674],"sequence,":[678],"\u2018full\u2019":[684,891],"codes":[688,725],"subunits":[692],"functional":[695,1300],"clustered":[699,731],"phylogenetic":[701,740,1370],"analyses":[702,743,786,1022,1353],"P-glycoproteins":[704],"toxic":[707,1452],"cells.":[711],"full.":[722],"most":[732],"closely":[733],"mammalian":[736],"subfamily":[737,940,1011],"ABCB10":[738],"performed":[745,1295,1354],"maximum":[748],"likelihood":[749],"method":[750],"calculated":[752],"distances":[754],"ATPase":[762],"(NBD)":[763],"based":[765,1437],"number":[768,1033],"nature":[770],"substitutions.":[774],"It":[775,1400],"impossible":[777],"entire":[781],"since":[787],"there":[788],"too":[790],"TMD":[795],"alignment":[799],"quality":[800],"them":[802],"poor.":[804],"investigate":[808],"concealed":[811],"variable":[814],"regions":[815],"position":[822,921],"introns":[824,923,1024,1342],"genes.":[828],"Although":[829],"interpretation":[831],"intron":[833,844,853,887,934,954,993],"still":[836],"riddle,":[838],"agreed":[841],"many":[843],"positions":[845,854,888,955,994],"evolution.":[849],"conservation":[851],"may":[855,1378,1444],"important":[857,1381],"shuffling":[859],"exons":[860],"modules":[864],"process":[867],"creating":[869],"control":[876],"via":[880],"splicing":[882],"mechanism.":[883],"investigation":[885],"revealed":[896],"locations":[899,904,935],"indeed":[900,1182,1408],"corresponded":[901],"\u201chomologous":[906],"introns\u201d":[907],"confer":[912],"drug":[913],"other":[916,938,1247],"organisms":[917,1051],"(e.g.,":[918],"humans).":[919],"transporter,":[929],"however,":[930],"did":[931,1199],"match":[933,949],"half":[943],"Interestingly,":[945],"almost":[947],"complete":[948],"recently":[966],"reported":[967,1244],"sea":[970],"urchin":[971],"Strongylocentrotus":[972],"purpuratus.":[973],"findings":[975],"distant":[980,1369],"lineages,":[981],"protostomia":[983],"(B.":[984],"pharaonis)":[985],"deuterostomia":[987],"(S.":[988],"purpuratus),":[989],"matching":[992],"similar":[998],"predicted":[1001],"sequences,":[1004],"suggests":[1005,1374],"existence":[1007,1357],"ancient":[1010],"yet":[1017],"identified":[1018],"humans.":[1020],"showed":[1026],"contain":[1030],"large":[1032],"introns,":[1035],"opposed":[1037],"arthropods,":[1039],"\u2018intron":[1041],"loss\u2019":[1042],"typical.":[1044],"demonstrates":[1046],"genome":[1048],"complexity":[1049],"traditionally":[1054],"been":[1055],"considered":[1056],"\u2018primitive\u2019.":[1057],"quantitative":[1066],"(ABCB1)":[1070],"transcription":[1071,1185],"purpose":[1078],"experiments":[1081,1181,1292],"protocol":[1087,1429],"biomonitoring":[1089,1142],"transport":[1096],"biomarkers":[1102],"stress":[1105],"invertebrates.":[1108],"Relatively":[1109],"high":[1110,1147],"translation":[1117],"measured":[1121],"polluted":[1123,1213,1240],"comparison":[1126],"pristine":[1128],"sites.":[1129],"Yet,":[1130],"relative":[1132],"increase":[1133],"parameters":[1136],"(ca.":[1137],"50-60%)":[1138],"marginal":[1140],"purposes":[1143],"variability":[1148],"individual":[1150],"specimens":[1151,1209],"natural":[1154,1426],"Therefore,":[1156],"mRNA-level":[1159],"more":[1163],"efficient":[1164],"study.":[1170],"Exposure":[1171],"controlled":[1179],"laboratory":[1180],"mRNA.":[1188],"Alas,":[1189],"quantities":[1194],"fields":[1196],"collected":[1197,1210],"samples":[1198],"demonstrate":[1201],"expectedly":[1203],"level":[1205],"at":[1211],"site.":[1214],"seasonal":[1218],"effect":[1219],"observed.":[1225],"Despite":[1226],"above,":[1228],"higher":[1237],"site,":[1241],"species.":[1249],"continue":[1253],"characterize":[1255],"biochemical":[1257],"properties":[1258],"pharaonis,":[1265,1443],"inserted":[1269],"mutant":[1272],"yeast":[1273],"strain":[1274],"sensitive":[1277],"While":[1281],"successfully":[1286],"expressed":[1287],"yeast,":[1290],"additional":[1291],"should":[1293],"obtain":[1299],"Such":[1302],"model":[1305],"will":[1307],"enable":[1308],"fast":[1309,1448],"screening":[1310,1449],"potential":[1312],"pollutants.":[1313],"results":[1315,1332],"presented":[1316],"contribute":[1320],"identification":[1323],"characterization":[1325],"molluscs.":[1330],"provide":[1333],"respect":[1337],"available":[1346],"phylum.":[1350],"Additionally,":[1351],"suggest":[1355],"novel":[1360],"sub":[1362],"retained":[1367],"groups.":[1371],"fact":[1373],"fulfill":[1379],"physiological":[1382],"research,":[1386],"apply":[1390],"inspected.":[1399],"exposure":[1411],"but":[1414],"responsive":[1417],"enough":[1418],"serve":[1420],"samples.":[1427],"developed":[1432],"quantifying":[1434],"expression,":[1436],"useful":[1446],"suspected":[1451],"compounds.":[1453]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
