{"id":"https://openalex.org/W2182913390","doi":null,"title":"Apoptogenic Activity of Secretion Extract of Bellamya Bengalensis f. Annandalei via Mitochondrial Mediated Caspase Cascade on Human Leukemic Cell Lines","display_name":"Apoptogenic Activity of Secretion Extract of Bellamya Bengalensis f. Annandalei via Mitochondrial Mediated Caspase Cascade on Human Leukemic Cell Lines","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2182913390","mag":"2182913390"},"language":"en","primary_location":{"id":"mag:2182913390","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/v20-1/25.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063636514","display_name":"Shila Elizabeth Besra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shila Elizabeth Besra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037734999","display_name":"Moumita Ray","orcid":"https://orcid.org/0000-0003-0012-1198","observed_orcids":["https://orcid.org/0000-0003-0012-1198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moumita Ray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0012-1198","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102841974","display_name":"Sayantan Dey","orcid":"https://orcid.org/0009-0009-4210-8435","observed_orcids":["https://orcid.org/0009-0009-4210-8435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayantan Dey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4210-8435","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062919693","display_name":"Subhadeep Roy","orcid":"https://orcid.org/0000-0002-0805-2505","observed_orcids":["https://orcid.org/0000-0002-0805-2505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhadeep Roy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0805-2505","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046228111","display_name":"Nilanjana Deb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nilanjana Deb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2199,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.48478072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12097","display_name":"Aquatic Invertebrate Ecology and Behavior","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antileukemic-activity","display_name":"antileukemic activity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9779999852180481},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8830000162124634},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":1.0},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6951276659965515},{"id":"https://openalex.org/C2908803906","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Apoptotic body","level":3,"score":0.555927574634552},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5330079197883606},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5147252082824707},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47365602850914},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4712018668651581},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4572036862373352},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4551808834075928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4495398998260498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44131559133529663},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4295828938484192},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4261135458946228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3028143644332886},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21335428953170776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08502987027168274},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.048004150390625}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182913390","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/v20-1/25.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1500271849","https://openalex.org/W1520282550","https://openalex.org/W1967912613","https://openalex.org/W1971967721","https://openalex.org/W1979995768","https://openalex.org/W1980280881","https://openalex.org/W1984866351","https://openalex.org/W1987276060","https://openalex.org/W1989722723","https://openalex.org/W1995398299","https://openalex.org/W2001262047","https://openalex.org/W2004956562","https://openalex.org/W2015061258","https://openalex.org/W2022469414","https://openalex.org/W2057556847","https://openalex.org/W2078532650","https://openalex.org/W2119683782","https://openalex.org/W2125947878","https://openalex.org/W2149967205","https://openalex.org/W2151501496","https://openalex.org/W2166291746","https://openalex.org/W2169637929","https://openalex.org/W4245391382"],"related_works":["https://openalex.org/W2138528625","https://openalex.org/W3093238693","https://openalex.org/W2381107566","https://openalex.org/W4416978098","https://openalex.org/W2117467796","https://openalex.org/W4245391382","https://openalex.org/W7099949610","https://openalex.org/W6976788546","https://openalex.org/W2167110010","https://openalex.org/W1927056228"],"abstract_inverted_index":{"Secretion":[0],"extract":[1,19],"of":[2,17,20,53,78,84,95,104,123,132],"Bellamya":[3,21],"bengalensis":[4,22],"f.":[5,23],"annandalei":[6,24],"have":[7],"been":[8,27,56],"traditionally":[9],"used":[10],"for":[11],"many":[12],"ailments.":[13],"The":[14,112,126],"anti-leukemic":[15],"activity":[16],"secretion":[18],"(SEBB)":[25],"has":[26,55],"investigated":[28],"against":[29],"three":[30],"human":[31],"leukemic":[32],"cell":[33,124],"lines":[34],"U937,":[35],"K562":[36],"and":[37,76,97],"HL-60":[38],"where":[39],"IC50":[40],"values":[41],"are":[42,81,114],"calculated":[43],"to":[44],"be":[45],"22.21\u00b5g/ml,":[46],"10.3\u00b5g/ml":[47],"&":[48,108,120,134],"12.79\u00b5g/ml":[49],"respectively.":[50],"Morphologically,":[51],"externalization":[52],"phosphatidyleserine":[54],"found":[57],"on":[58],"all":[59],"the":[60,93,118],"treated":[61],"cells":[62,105,113],"but":[63],"not":[64],"in":[65,92,106,117],"control":[66],"cells.":[67],"Cell":[68],"shrinkage,":[69],"membrane":[70],"blebbing,":[71],"chromatin":[72],"condensation,":[73],"nuclear":[74],"fragmentation":[75],"formation":[77],"apoptotic":[79,110],"bodies":[80],"characteristic":[82],"features":[83],"apoptosis.":[85],"Gel":[86],"electrophoresis":[87],"study":[88],"shows":[89],"fragmented":[90],"DNA":[91],"form":[94],"ladder":[96],"Flow":[98],"cytometric":[99],"analysis":[100],"showed":[101],"appreciable":[102],"number":[103],"early":[107],"late":[109],"stages.":[111],"getting":[115],"arrested":[116],"sub-G1":[119],"G1":[121],"phases":[122],"cycle.":[125],"apoptosis":[127],"is":[128],"mediated":[129],"through":[130],"activation":[131],"caspase-9":[133],"Caspase-3.":[135]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
