{"id":"https://openalex.org/W2182911352","doi":null,"title":"Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain.","display_name":"Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2182911352","mag":"2182911352","pmid":"https://pubmed.ncbi.nlm.nih.gov/10871768"},"language":"en","primary_location":{"id":"pmid:10871768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100604036","display_name":"Yiling Liu","orcid":"https://orcid.org/0000-0002-5344-7581","observed_orcids":["https://orcid.org/0000-0002-5344-7581"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Liu","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, MA 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, MA 21287, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023621587","display_name":"Xiao Pei Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X P Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038368249","display_name":"Justin C. McArthur","orcid":"https://orcid.org/0000-0002-3512-771X","observed_orcids":["https://orcid.org/0000-0002-3512-771X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C McArthur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085601780","display_name":"Jason M. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110122858","display_name":"Suzanne Gartner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Gartner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6842,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.91335636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6 Suppl 1","issue":null,"first_page":"S70","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hiv-1-gp160","display_name":"HIV-1 gp160","score":0.9419999718666077},{"id":"https://openalex.org/keywords/monocyte-trafficking","display_name":"monocyte trafficking","score":0.8619999885559082},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.3070000112056732},{"id":"https://openalex.org/keywords/bone-marrow-derived-monocytes","display_name":"bone marrow-derived monocytes","score":0.796999990940094},{"id":"https://openalex.org/keywords/deep-white-matter","display_name":"deep white matter","score":0.8659999966621399},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/meninges","display_name":"meninges","score":0.984000027179718},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/g-to-a-hypermutation","display_name":"G-to-A hypermutation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/stop-codon-mutation","display_name":"stop codon mutation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/viral-phylogeny","display_name":"viral phylogeny","score":0.5730000138282776},{"id":"https://openalex.org/keywords/postmortem-tissue","display_name":"postmortem tissue","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.6575068235397339},{"id":"https://openalex.org/C2776403516","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Meninges","level":2,"score":0.6008058786392212},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5820008516311646},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5631672739982605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5593252778053284},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5061637759208679},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.476915568113327},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4231772720813751},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4228753447532654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35886502265930176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26559334993362427},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22959139943122864},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20758378505706787},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019302","descriptor_name":"HIV Envelope Protein gp160","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019302","descriptor_name":"HIV Envelope Protein gp160","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10871768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurovirology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.415.4871","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.415.4871","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurovirol.com/pdf/6(s1)/s70-s81.pdf","raw_type":"text"},{"id":"mag:2182911352","doi":null,"is_oa":false,"landing_page_url":"http://jneurovirol.com/pdf/6(s1)/s70-s81.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2409261665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10871768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1531670012","display_name":"RESEARCH CENTERS FOR AIDS DEMENTIA","funder_award_id":"P01NS026643","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G177724020","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000722","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7020277055","display_name":"HIV IN THE BRAIN--MODE OF ENTRY, GENOTYPE AND DEMENTIA","funder_award_id":"R01NS035736","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1915828783","https://openalex.org/W1965325073","https://openalex.org/W1965774871","https://openalex.org/W1988140844","https://openalex.org/W1995924099","https://openalex.org/W1996639413","https://openalex.org/W1999136843","https://openalex.org/W2011210970","https://openalex.org/W2011459593","https://openalex.org/W2011989483","https://openalex.org/W2014462005","https://openalex.org/W2024018223","https://openalex.org/W2024442062","https://openalex.org/W2036556737","https://openalex.org/W2044919475","https://openalex.org/W2051077211","https://openalex.org/W2053823051","https://openalex.org/W2064501916","https://openalex.org/W2071704136","https://openalex.org/W2073004681","https://openalex.org/W2077968305","https://openalex.org/W2079935738","https://openalex.org/W2120606210","https://openalex.org/W2123505400","https://openalex.org/W2132674999","https://openalex.org/W2142411170","https://openalex.org/W2151036708","https://openalex.org/W2152364824","https://openalex.org/W2163400707","https://openalex.org/W2164606932","https://openalex.org/W2294962982","https://openalex.org/W2308454504","https://openalex.org/W2312778470","https://openalex.org/W2409385743","https://openalex.org/W2442041971","https://openalex.org/W2474910871"],"related_works":["https://openalex.org/W2409261665","https://openalex.org/W2038474674","https://openalex.org/W1997815674","https://openalex.org/W7095862898","https://openalex.org/W4388360034","https://openalex.org/W2121511328","https://openalex.org/W2184683090","https://openalex.org/W1613383360","https://openalex.org/W2152364824","https://openalex.org/W2148314976"],"abstract_inverted_index":{"Towards":[0],"understanding":[1],"the":[2,44,77,96,108,120,161,172,180,184,190,200,212],"pathogenesis":[3],"of":[4,41,49,115,128,145,163,174,202],"HIV":[5,29,203],"dementia,":[6],"we":[7],"molecularly":[8],"cloned":[9],"and":[10,38,53,99,138,141,166,187,214],"sequenced":[11],"human":[12],"immundeficiency":[13],"virus":[14],"type":[15],"1":[16],"(HIV-1)":[17],"gp160":[18,61],"genes":[19],"from":[20,25,32,64,79,89,95,107,134,179],"uncultured":[21],"post-mortem":[22],"tissues":[23],"collected":[24,67],"a":[26,196],"patient":[27],"with":[28],"dementia.":[30],"Sequences":[31],"bone":[33,90,116],"marrow,":[34,91],"lymph":[35,139,191],"node,":[36,140],"lung,":[37],"four":[39,146],"regions":[40],"brain":[42],"-":[43,55],"deep":[45,80,121],"white":[46,81,122],"matter,":[47],"head":[48],"caudate,":[50],"choroid":[51,135,181],"plexus":[52,182],"meninges":[54,137],"were":[56,60,83,101,151],"compared.":[57],"Also":[58],"included":[59,132],"sequences":[62,78,106,133],"recovered":[63],"blood":[65,109],"monocytes":[66,118],"5":[68],"months":[69],"prior":[70],"to":[71,87,93,105,159],"death.":[72],"Phylogenetic":[73],"analyses":[74],"showed":[75],"that":[76,195,215],"matter":[82,123],"more":[84],"closely":[85,103],"related":[86,104],"those":[88,94],"than":[92],"other":[97],"tissues,":[98],"moreover,":[100],"most":[102],"monocytes.":[110],"These":[111,156],"findings":[112],"suggest":[113],"trafficking":[114,210],"marrow-derived":[117],"into":[119,183,189,211],"during":[124,223,233],"this":[125,216,234],"late":[126],"stage":[127],"infection.":[129],"Another":[130],"cluster":[131],"plexus,":[136],"interestingly,":[142],"identical":[143],"patterns":[144],"or":[147,171,176],"nine":[148],"stop":[149],"codons":[150],"shared":[152],"among":[153],"these":[154],"tissues.":[155],"mutations":[157],"appear":[158],"be":[160],"consequence":[162],"G-->A":[164],"hypermutation,":[165],"could":[167,227],"reflect":[168],"independent":[169],"events,":[170],"movement":[173],"virions":[175],"infected":[177],"cells,":[178],"cerebrospinal":[185],"fluid":[186],"ultimately,":[188],"node.":[192],"We":[193],"propose":[194],"critical":[197],"step":[198],"towards":[199],"development":[201],"dementia":[204,230],"is":[205,218],"an":[206],"increase":[207],"in":[208],"monocyte":[209],"brain,":[213],"process":[217],"either":[219],"initiated":[220],"and/or":[221],"accelerated":[222],"late-stage":[224],"infection,":[225],"which":[226],"explain":[228],"why":[229],"occurs":[231],"primarily":[232],"time.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
