{"id":"https://openalex.org/W2182909367","doi":null,"title":"Investigating the effect of differences in entry criteria on trial populations: a method with an application in severe sepsis.","display_name":"Investigating the effect of differences in entry criteria on trial populations: a method with an application in severe sepsis.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2182909367","mag":"2182909367","pmid":"https://pubmed.ncbi.nlm.nih.gov/16160390"},"language":"en","primary_location":{"id":"pmid:16160390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16160390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102853771","display_name":"Linda M. Peelen","orcid":"https://orcid.org/0000-0003-0269-0095","observed_orcids":["https://orcid.org/0000-0003-0269-0095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Peelen","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam, The Netherlands.l.m.peelen@amc.uva.nl","Department of Medical Informatics, Amsterdam, The"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam, The Netherlands.l.m.peelen@amc.uva.nl","institution_ids":[]},{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam, The","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059494163","display_name":"Niels B. Peek","orcid":"https://orcid.org/0000-0002-6393-9969","observed_orcids":["https://orcid.org/0000-0002-6393-9969"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Peek","raw_affiliation_strings":["Amsterdam Cardiovascular Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Cardiovascular Sciences","institution_ids":["https://openalex.org/I4405257531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040614650","display_name":"Nicolette F. de Keizer","orcid":"https://orcid.org/0000-0002-6651-1730","observed_orcids":["https://orcid.org/0000-0002-6651-1730"]},"institutions":[{"id":"https://openalex.org/I4210124285","display_name":"Amsterdam Public Health","ror":"https://ror.org/0258apj61","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210124285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicolette de Keizer","raw_affiliation_strings":["Amsterdam Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Public Health","institution_ids":["https://openalex.org/I4210124285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002897147","display_name":"Evert de Jonge","orcid":"https://orcid.org/0000-0003-1431-8039","observed_orcids":["https://orcid.org/0000-0003-1431-8039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evert de Jonge","raw_affiliation_strings":["Intensive Care Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":null,"first_page":"1004","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/admission-requirements","display_name":"admission requirements","score":0.6510000228881836},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.5820000171661377},{"id":"https://openalex.org/keywords/clinical-trial-populations","display_name":"clinical trial populations","score":0.609000027179718},{"id":"https://openalex.org/keywords/severe-sepsis","display_name":"severe sepsis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/clinical-heterogeneity","display_name":"clinical heterogeneity","score":0.6290000081062317},{"id":"https://openalex.org/keywords/selection-bias","display_name":"selection bias","score":0.5450000166893005},{"id":"https://openalex.org/keywords/trial-comparability","display_name":"trial comparability","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6704435348510742},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6272742748260498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5415762662887573},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.4823562502861023},{"id":"https://openalex.org/C40423286","wikidata":"https://www.wikidata.org/wiki/Q284172","display_name":"Selection bias","level":2,"score":0.43969401717185974},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3356948792934418},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2764672636985779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2084173560142517},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13979408144950867},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13417315483093262},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"pmid:16160390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16160390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/b9b0885f-88e2-4df2-84e4-fb56d25e6fd3","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/investigating-the-effect-of-differences-in-entry-criteria-on-trial-populations-a-method-with-an-application-in-severe-sepsis(b9b0885f-88e2-4df2-84e4-fb56d25e6fd3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Studies in health technology and informatics, 116, 1004 - 1009. IOS Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/f25dfd14-e8ba-47ec-8659-8637310063e0","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/investigating-the-effect-of-differences-in-entry-criteria-on-trial-populations-a-method-with-an-application-in-severe-sepsis(f25dfd14-e8ba-47ec-8659-8637310063e0).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of MIE2005 section 13, 1004 - 1009","raw_type":"info:eu-repo/semantics/bookpart"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/7364ef48-aba9-44a8-a64a-974376654c9f","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/7364ef48-aba9-44a8-a64a-974376654c9f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Peelen, L, Peek, N, de Keizer, N & de Jonge, E 2005, Investigating the effect of differences in entry criteria on trial populations: a method with an application in severe sepsis. in Proceedings of MIE2005 section 13. Public health tinformatics, Clinical trials, S.l., pp. 1004-1009.","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e5f6ed3f-525d-4c2f-b508-27228a72c534","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e5f6ed3f-525d-4c2f-b508-27228a72c534","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Peelen, L, Peek, N, de Keizer, N & de Jonge, E 2005, 'Investigating the effect of differences in entry criteria on trial populations: a method with an application in severe sepsis', Studies in health technology and informatics, vol. 116, pp. 1004-1009.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2182909367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16160390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1511524925","https://openalex.org/W1917557897","https://openalex.org/W1984525438","https://openalex.org/W2017210303","https://openalex.org/W2027752637","https://openalex.org/W2042956469","https://openalex.org/W2058223996","https://openalex.org/W2073545808","https://openalex.org/W2091330377","https://openalex.org/W2097879961","https://openalex.org/W2108435955","https://openalex.org/W2115301416","https://openalex.org/W2124181495","https://openalex.org/W2167025863","https://openalex.org/W2322121630","https://openalex.org/W2341811425","https://openalex.org/W3026721701"],"related_works":["https://openalex.org/W1988668215","https://openalex.org/W2075535181","https://openalex.org/W2159260463","https://openalex.org/W2010982832","https://openalex.org/W3129441165","https://openalex.org/W2790798571","https://openalex.org/W2081052240","https://openalex.org/W2151388351","https://openalex.org/W2961545329","https://openalex.org/W4383163862"],"abstract_inverted_index":{"Multiple":[0],"clinical":[1,124,165],"trials":[2,56,132],"that":[3],"investigate":[4,66,144],"the":[5,17,27,40,52,55,68,76,86,89,95,98,102,128,131,145,153,162,169,185],"same":[6],"intervention":[7],"often":[8],"use":[9,69,94],"different":[10,32,71,81],"entry":[11,22,72,118,150],"criteria":[12,23,73,119,151],"to":[13,26,39,65,75,143],"enroll":[14],"patients":[15,30,79],"into":[16],"trials.":[18,103],"This":[19],"variation":[20],"in":[21,46,85,106,117,149,184],"might":[24],"lead":[25],"selection":[28,77,171],"of":[29,54,70,78,88,101,108,147,155,164,187],"with":[31,80],"characteristics.":[33],"If":[34],"these":[35,109,133],"characteristics":[36,87,107,154],"are":[37],"related":[38],"effect":[41],"measure":[42],"(e.g.":[43],"baseline":[44],"mortality":[45,50],"a":[47,141],"trial":[48],"investigating":[49],"reduction)":[51],"results":[53],"cannot":[57,136],"be":[58,113,137],"compared":[59],"straightforwardly.":[60],"Therefore":[61],"it":[62],"is":[63],"important":[64],"whether":[67],"leads":[74],"characteristics.To":[82],"study":[83,90,110,156],"differences":[84,105,116,148],"populations,":[91],"one":[92],"could":[93],"data":[96,129],"from":[97,130],"control":[99],"groups":[100],"However,":[104],"populations":[111],"can":[112],"caused":[114],"by":[115,123,167],"as":[120,122],"well":[121],"diversity.":[125],"Based":[126],"on":[127,152,173],"two":[134],"causes":[135],"distinguished.":[138],"We":[139],"propose":[140],"method":[142,159,179],"influence":[146],"populations.":[157],"The":[158,178],"corrects":[160],"for":[161],"effects":[163],"diversity":[166],"simulating":[168],"patient":[170],"process":[172],"an":[174],"independent":[175],"registry":[176],"database.":[177],"has":[180],"been":[181],"successfully":[182],"applied":[183],"area":[186],"severe":[188],"sepsis.":[189]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
