{"id":"https://openalex.org/W2182908996","doi":null,"title":"Triptolide: Novel Anticancer Agent for Chemoresistant Cancer Cells that are Caspase-3 Deficient","display_name":"Triptolide: Novel Anticancer Agent for Chemoresistant Cancer Cells that are Caspase-3 Deficient","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182908996","mag":"2182908996"},"language":"en","primary_location":{"id":"mag:2182908996","doi":null,"is_oa":false,"landing_page_url":"https://www.montclair.edu/profilepages/media/239/user/fulltext-jmbmi-v1-id1011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017013096","display_name":"Reginald Halaby","orcid":"https://orcid.org/0000-0002-1814-0074","observed_orcids":["https://orcid.org/0000-0002-1814-0074"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Reginald Halaby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017013096"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2009,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89717858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triptolide","display_name":"triptolide","score":1.0},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5830000042915344},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2781164371","wikidata":"https://www.wikidata.org/wiki/Q906351","display_name":"Triptolide","level":3,"score":0.9854549169540405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7313550710678101},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6602001786231995},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6112707257270813},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5939522385597229},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5841307640075684},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5756166577339172},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5093554258346558},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.49280527234077454},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47337645292282104},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.41846412420272827},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3741723597049713},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32462650537490845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26035934686660767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17297664284706116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182908996","doi":null,"is_oa":false,"landing_page_url":"https://www.montclair.edu/profilepages/media/239/user/fulltext-jmbmi-v1-id1011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":126,"referenced_works":["https://openalex.org/W6760901","https://openalex.org/W26477306","https://openalex.org/W91317548","https://openalex.org/W109599821","https://openalex.org/W167646857","https://openalex.org/W170881775","https://openalex.org/W192309737","https://openalex.org/W199340428","https://openalex.org/W1242125470","https://openalex.org/W1595815978","https://openalex.org/W1602167922","https://openalex.org/W1964321121","https://openalex.org/W1964475578","https://openalex.org/W1968958068","https://openalex.org/W1969876249","https://openalex.org/W1971967721","https://openalex.org/W1972708772","https://openalex.org/W1974024530","https://openalex.org/W1974724607","https://openalex.org/W1989116049","https://openalex.org/W1992699288","https://openalex.org/W1994342907","https://openalex.org/W1997093306","https://openalex.org/W1997287699","https://openalex.org/W1998258610","https://openalex.org/W2004258040","https://openalex.org/W2006456311","https://openalex.org/W2008803913","https://openalex.org/W2009275720","https://openalex.org/W2010653836","https://openalex.org/W2011162627","https://openalex.org/W2013842624","https://openalex.org/W2014028880","https://openalex.org/W2016924852","https://openalex.org/W2017593971","https://openalex.org/W2021028337","https://openalex.org/W2021392425","https://openalex.org/W2021825721","https://openalex.org/W2021937419","https://openalex.org/W2022520367","https://openalex.org/W2025266243","https://openalex.org/W2025680861","https://openalex.org/W2025743107","https://openalex.org/W2026492144","https://openalex.org/W2026564047","https://openalex.org/W2030410023","https://openalex.org/W2033374599","https://openalex.org/W2034612383","https://openalex.org/W2039317789","https://openalex.org/W2040340572","https://openalex.org/W2040598795","https://openalex.org/W2042710439","https://openalex.org/W2043983761","https://openalex.org/W2044790158","https://openalex.org/W2045563337","https://openalex.org/W2045781729","https://openalex.org/W2049110814","https://openalex.org/W2052276111","https://openalex.org/W2052828768","https://openalex.org/W2054107351","https://openalex.org/W2054543570","https://openalex.org/W2055878807","https://openalex.org/W2057333190","https://openalex.org/W2057636545","https://openalex.org/W2057832032","https://openalex.org/W2061836260","https://openalex.org/W2063569562","https://openalex.org/W2065346431","https://openalex.org/W2066052096","https://openalex.org/W2066606648","https://openalex.org/W2067829242","https://openalex.org/W2074260104","https://openalex.org/W2074688366","https://openalex.org/W2076513051","https://openalex.org/W2077772036","https://openalex.org/W2078387542","https://openalex.org/W2079380429","https://openalex.org/W2080836582","https://openalex.org/W2081338931","https://openalex.org/W2083222043","https://openalex.org/W2086922935","https://openalex.org/W2090037073","https://openalex.org/W2094321211","https://openalex.org/W2096565534","https://openalex.org/W2099818428","https://openalex.org/W2102570939","https://openalex.org/W2102768460","https://openalex.org/W2107948773","https://openalex.org/W2110407418","https://openalex.org/W2111478927","https://openalex.org/W2111650534","https://openalex.org/W2112967298","https://openalex.org/W2115646840","https://openalex.org/W2115954319","https://openalex.org/W2116048534","https://openalex.org/W2116854153","https://openalex.org/W2117034500","https://openalex.org/W2118033970","https://openalex.org/W2128120989","https://openalex.org/W2128370501","https://openalex.org/W2130120558","https://openalex.org/W2130301080","https://openalex.org/W2130637870","https://openalex.org/W2132167157","https://openalex.org/W2134189872","https://openalex.org/W2135196225","https://openalex.org/W2136364303","https://openalex.org/W2142054470","https://openalex.org/W2143681410","https://openalex.org/W2144671906","https://openalex.org/W2157514563","https://openalex.org/W2157815025","https://openalex.org/W2159997162","https://openalex.org/W2160015793","https://openalex.org/W2163357689","https://openalex.org/W2163468787","https://openalex.org/W2163685397","https://openalex.org/W2164277862","https://openalex.org/W2166834236","https://openalex.org/W2167889783","https://openalex.org/W2169186449","https://openalex.org/W2170659029","https://openalex.org/W2304923550","https://openalex.org/W2417146944","https://openalex.org/W2433358857","https://openalex.org/W3145640839"],"related_works":["https://openalex.org/W2807427890","https://openalex.org/W4323294090","https://openalex.org/W26477306","https://openalex.org/W3173461834","https://openalex.org/W2111363518","https://openalex.org/W2080150047","https://openalex.org/W2161210582","https://openalex.org/W4390732089","https://openalex.org/W2127215233","https://openalex.org/W4406815083"],"abstract_inverted_index":{"Cancer":[0],"is":[1,77,95],"a":[2,145,188],"major":[3],"cause":[4],"of":[5,15,33,87,99,164],"death":[6,183],"worldwide":[7],"and":[8,28,35,57,63,82,103,128,158],"there":[9],"are":[10,65],"over":[11,152],"100":[12],"different":[13],"types":[14],"cancers.":[16],"The":[17,85],"current":[18],"treatment":[19,196],"strategies":[20],"for":[21,151],"cancer":[22,53,94,134],"patients":[23],"such":[24,60],"as":[25,61],"surgery,":[26],"chemotherapy":[27,36,62],"radiation":[29,64],"or":[30],"the":[31,45,91,117,122],"combination":[32],"radiotherapy":[34],"may":[37,104,191],"have":[38,68],"successfully":[39],"increased":[40],"five-year":[41],"survival":[42,47],"rates.":[43],"However,":[44],"long-term":[46],"rates":[48],"remain":[49],"poor":[50],"due":[51],"to":[52,67,79,107,155],"relapse,":[54],"tumor":[55,101],"resistance":[56],"metastasis.":[58],"Treatments":[59],"known":[66],"untoward":[69],"side":[70],"effects":[71],"on":[72],"normal":[73],"cells.":[74],"Therefore,":[75],"it":[76],"imperative":[78],"develop":[80],"safer":[81],"noninvasive":[83],"treatments.":[84],"use":[86],"natural":[88],"products":[89],"in":[90],"fight":[92],"against":[93],"one":[96],"possible":[97],"way":[98],"slowing":[100],"growth":[102],"allow":[105],"us":[106],"design":[108],"more":[109],"effective":[110,193],"therapies.":[111],"In":[112],"this":[113,142],"review,":[114],"we":[115],"examine":[116],"central":[118],"role":[119],"played":[120],"by":[121,132,140,186],"key":[123],"apoptotic":[124],"executioner":[125],"protease,":[126],"caspase-3":[127,179],"propose":[129],"molecular":[130],"mechanisms":[131],"which":[133],"cells":[135],"can":[136],"evade":[137],"anticancer":[138,171],"treatments":[139],"mutating":[141],"protein.":[143],"Triptolide,":[144],"Chinese":[146,189],"herb,":[147,190],"has":[148,169],"been":[149],"used":[150],"200":[153],"years":[154],"treat":[156],"anti-inflammatory":[157],"autoimmune":[159],"disorders.":[160],"A":[161],"considerable":[162],"body":[163],"data":[165],"indicates":[166],"that":[167,178],"triptolide":[168],"potent":[170],"properties.":[172],"We":[173],"provide":[174,192],"supporting":[175],"evidence":[176],"demonstrating":[177],"independent":[180],"cell,":[181],"lysosomalmediated":[182],"pathways":[184],"induced":[185],"triptolide,":[187],"novel":[194],"antitumor":[195],"modalities.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}