{"id":"https://openalex.org/W2182887751","doi":"https://doi.org/10.2174/1573406411666151030112140","title":"miRNAs as Circulating Biomarkers for Alzheimer's Disease and Parkinson's Disease","display_name":"miRNAs as Circulating Biomarkers for Alzheimer's Disease and Parkinson's Disease","publication_year":2016,"publication_date":"2016-03-31","ids":{"openalex":"https://openalex.org/W2182887751","doi":"https://doi.org/10.2174/1573406411666151030112140","mag":"2182887751","pmid":"https://pubmed.ncbi.nlm.nih.gov/26527155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6138249"},"language":"en","primary_location":{"id":"doi:10.2174/1573406411666151030112140","doi":"https://doi.org/10.2174/1573406411666151030112140","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573406411666151030112140","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6138249","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061700037","display_name":"Gohar Mushtaq","orcid":"https://orcid.org/0000-0003-4880-4035","observed_orcids":["https://orcid.org/0000-0003-4880-4035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gohar Mushtaq","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056649584","display_name":"Nigel H. Greig","orcid":"https://orcid.org/0000-0002-3032-1468","observed_orcids":["https://orcid.org/0000-0002-3032-1468"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel H. Greig","raw_affiliation_strings":["Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. greign@mail.nih.gov","Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.,United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. greign@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.,United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007572142","display_name":"Firoz Anwar","orcid":"https://orcid.org/0000-0002-4980-0880","observed_orcids":["https://orcid.org/0000-0002-4980-0880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Firoz Anwar","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041261572","display_name":"Mazin Abdulaziz Zamzami","orcid":"https://orcid.org/0000-0002-6709-3227","observed_orcids":["https://orcid.org/0000-0002-6709-3227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mazin A. Zamzami","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052176501","display_name":"Hani Choudhry","orcid":"https://orcid.org/0000-0003-0401-6619","observed_orcids":["https://orcid.org/0000-0003-0401-6619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hani Choudhry","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026822249","display_name":"Munvar Miya Shaik","orcid":"https://orcid.org/0000-0002-7053-9461","observed_orcids":["https://orcid.org/0000-0002-7053-9461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Munvar M. Shaik","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009691688","display_name":"Ian A. Tamargo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian A. Tamargo","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040140025","display_name":"Mohammad Amjad Kamal","orcid":"https://orcid.org/0000-0003-0088-0565","observed_orcids":["https://orcid.org/0000-0003-0088-0565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad A. Kamal","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8232,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.90103768,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"217","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9829999804496765},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8970000147819519},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9350000023841858},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.8143092393875122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5726020932197571},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5518211722373962},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5198407769203186},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.4759133458137512},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.387889564037323},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3420933783054352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19863176345825195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14824023842811584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13450291752815247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1573406411666151030112140","doi":"https://doi.org/10.2174/1573406411666151030112140","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573406411666151030112140","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:26527155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26527155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal chemistry (Shariqah (United Arab Emirates))","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5087575","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6138249","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6138249","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6138249","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5087575","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6138249","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7423759087","display_name":null,"funder_award_id":"Z99 AG999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000893074","display_name":"ALZHEIMERS RESEARCH PROJECT:  Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)","funder_award_id":"ZIAAG000311","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W32204808","https://openalex.org/W75341900","https://openalex.org/W210812702","https://openalex.org/W1527671059","https://openalex.org/W1605551280","https://openalex.org/W1953883287","https://openalex.org/W1964855333","https://openalex.org/W1970994012","https://openalex.org/W1971726501","https://openalex.org/W1978337436","https://openalex.org/W1978605940","https://openalex.org/W1981458288","https://openalex.org/W1986820918","https://openalex.org/W1990427131","https://openalex.org/W1992483894","https://openalex.org/W1993576110","https://openalex.org/W1999493217","https://openalex.org/W2000356500","https://openalex.org/W2001653341","https://openalex.org/W2003172650","https://openalex.org/W2003206209","https://openalex.org/W2007759608","https://openalex.org/W2013957662","https://openalex.org/W2014229306","https://openalex.org/W2015440966","https://openalex.org/W2017422058","https://openalex.org/W2019028138","https://openalex.org/W2022406334","https://openalex.org/W2023838539","https://openalex.org/W2025560247","https://openalex.org/W2025563134","https://openalex.org/W2029533272","https://openalex.org/W2030011049","https://openalex.org/W2030815417","https://openalex.org/W2033285750","https://openalex.org/W2033797433","https://openalex.org/W2038622868","https://openalex.org/W2041945875","https://openalex.org/W2044510533","https://openalex.org/W2044539596","https://openalex.org/W2047565527","https://openalex.org/W2055103272","https://openalex.org/W2057082801","https://openalex.org/W2057558239","https://openalex.org/W2059382687","https://openalex.org/W2061543605","https://openalex.org/W2066398961","https://openalex.org/W2067100763","https://openalex.org/W2067901314","https://openalex.org/W2072484559","https://openalex.org/W2074480115","https://openalex.org/W2079030291","https://openalex.org/W2082429191","https://openalex.org/W2086412028","https://openalex.org/W2088875650","https://openalex.org/W2089831044","https://openalex.org/W2105799245","https://openalex.org/W2112324137","https://openalex.org/W2119043140","https://openalex.org/W2120522615","https://openalex.org/W2122866775","https://openalex.org/W2132014056","https://openalex.org/W2135059214","https://openalex.org/W2135309875","https://openalex.org/W2135613885","https://openalex.org/W2137085566","https://openalex.org/W2137669678","https://openalex.org/W2140449918","https://openalex.org/W2141792156","https://openalex.org/W2144339761","https://openalex.org/W2147993839","https://openalex.org/W2148641246","https://openalex.org/W2151922790","https://openalex.org/W2153763768","https://openalex.org/W2155875767","https://openalex.org/W2157069791","https://openalex.org/W2163482204","https://openalex.org/W2168334242","https://openalex.org/W2170357356","https://openalex.org/W2171833185","https://openalex.org/W2335768447","https://openalex.org/W3023013291","https://openalex.org/W4243693606","https://openalex.org/W4246230178"],"related_works":["https://openalex.org/W2467727872","https://openalex.org/W2113700618","https://openalex.org/W2890358153","https://openalex.org/W1941189250","https://openalex.org/W2803498036","https://openalex.org/W1999493217","https://openalex.org/W2018509689","https://openalex.org/W2057082801","https://openalex.org/W7095581641","https://openalex.org/W2000593287"],"abstract_inverted_index":{"Detection":[0],"of":[1,10,31,43,51,58,87,95,106,157,164,185,199],"biomarkers":[2,151],"for":[3,84,167],"neurodegenerative":[4],"disorders":[5],"(NDDs)":[6],"within":[7,91,137],"brain":[8,33],"tissues":[9],"Alzheimer's":[11],"disease":[12,16,37,59,89,158,165,218,231],"(AD)":[13],"and":[14,28,39,73,124,133,139,146,159,172,191,201],"Parkinson's":[15],"(PD)":[17],"patients":[18,96],"has":[19],"always":[20],"been":[21],"hampered":[22],"by":[23,62],"our":[24],"inability":[25],"to":[26,70,82,224],"access":[27],"biopsy":[29],"tissue":[30],"key":[32],"regions":[34],"implicated":[35],"in":[36,109,210,229],"occurrence":[38],"progression.":[40],"Currently,":[41],"diagnosis":[42],"NDDs":[44,75,168],"is":[45,81,104,178,205],"principally":[46],"based":[47],"on":[48],"clinical":[49],"observations":[50],"symptoms":[52],"that":[53,102,129,152],"present":[54],"at":[55,76],"later":[56],"stages":[57],"progression,":[60],"followed":[61],"neuroimaging":[63],"and,":[64,209],"possibly,":[65],"CSF":[66],"evaluation.":[67],"One":[68],"way":[69],"potentially":[71,160],"detect":[72],"diagnose":[74],"a":[77,176,182],"far":[78],"earlier":[79,228],"stage":[80],"screen":[83,177],"abnormal":[85],"levels":[86],"specific":[88],"markers":[90],"the":[92,154,161,197,211,222,230],"peripheral":[93],"circulation":[94],"with":[97,181,189],"NDDs.":[98,110],"Increasing":[99],"evidence":[100],"suggests":[101],"there":[103],"dysregulation":[105],"microRNAs":[107],"(miRNAs)":[108],"Peripheral":[111],"blood":[112,138],"mononuclear":[113],"cells,":[114],"as":[115,117,120,148,170],"well":[116],"biofluids,":[118],"such":[119,169,175],"plasma,":[121],"serum,":[122],"urine":[123],"cerebrospinal":[125],"fluid,":[126],"contain":[127],"miRNAs":[128,136,187],"can":[130],"be":[131,144],"identified":[132],"quantified.":[134],"Circulating":[135],"other":[140],"biofluids":[141],"may":[142,214],"thus":[143],"characterized":[145],"used":[147],"non-invasive,":[149],"diagnostic":[150],"facilitate":[153],"early":[155],"detection":[156],"continual":[162],"monitoring":[163],"progression":[166,198],"AD":[171,200],"PD.":[173,202],"Plainly,":[174],"only":[179,216],"possible":[180],"clear":[183],"understanding":[184],"which":[186],"change":[188],"disease,":[190],"when":[192],"these":[193],"changes":[194],"occur":[195],"during":[196],"Such":[203],"information":[204],"becoming":[206],"increasingly":[207],"available":[208],"near":[212],"future,":[213],"not":[215],"support":[217],"diagnosis,":[219],"but":[220],"provide":[221],"opportunity":[223],"evaluate":[225],"therapeutic":[226],"interventions":[227],"process.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}