{"id":"https://openalex.org/W2182849043","doi":"https://doi.org/10.1007/978-1-59259-101-5_7","title":"Structure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory (StAR) Protein","display_name":"Structure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory (StAR) Protein","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2182849043","doi":"https://doi.org/10.1007/978-1-59259-101-5_7","mag":"2182849043"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-101-5_7","doi":"https://doi.org/10.1007/978-1-59259-101-5_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-101-5_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adrenal Disorders","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4254026447","display_name":"Adrenal Disorders"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031110199","display_name":"Caleb B. Kallen","orcid":"https://orcid.org/0000-0002-4156-6719","observed_orcids":["https://orcid.org/0000-0002-4156-6719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caleb B. Kallen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110651270","display_name":"Futoshi Arakane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Futoshi Arakane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110385785","display_name":"Teruo Sugawara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teruo Sugawara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074781235","display_name":"Marianthi Kiriakidou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianthi Kiriakidou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050395062","display_name":"Staci E. Pollack","orcid":"https://orcid.org/0000-0003-2423-6280","observed_orcids":["https://orcid.org/0000-0003-2423-6280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Staci E. Pollack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036752654","display_name":"Hidemichi Watari","orcid":"https://orcid.org/0000-0002-4189-6187","observed_orcids":["https://orcid.org/0000-0002-4189-6187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidemichi Watari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048183362","display_name":"Lane K. Christenson","orcid":"https://orcid.org/0000-0003-3846-5674","observed_orcids":["https://orcid.org/0000-0003-3846-5674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lane K. Christenson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036278059","display_name":"Michiko Watari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michiko Watari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090491933","display_name":"Jerome F. Strauss","orcid":"https://orcid.org/0000-0001-6199-0480","observed_orcids":["https://orcid.org/0000-0001-6199-0480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerome F. Strauss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.25083612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"107","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroidogenic-acute-regulatory-protein","display_name":"steroidogenic acute regulatory protein","score":0.9570000171661377},{"id":"https://openalex.org/keywords/stars","display_name":"stars","score":0.878000020980835},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cholesterol-transport","display_name":"cholesterol transport","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cytochrome-p450-side-chain-cleavage","display_name":"cytochrome P450 side-chain cleavage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pregnenolone-synthesis","display_name":"pregnenolone synthesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/congenital-lipoid-adrenal-hyperplasia","display_name":"congenital lipoid adrenal hyperplasia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/steroidogenic-factor-1","display_name":"steroidogenic factor 1","score":0.949999988079071},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-kinase-a-phosphorylation","display_name":"protein kinase A phosphorylation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mitochondrial-protein-import","display_name":"mitochondrial protein import","score":0.6700000166893005},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.8629999756813049},{"id":"https://openalex.org/keywords/inner-mitochondrial-membrane","display_name":"inner mitochondrial membrane","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2779670467","wikidata":"https://www.wikidata.org/wiki/Q24727595","display_name":"Steroidogenic acute regulatory protein","level":4,"score":0.9530248641967773},{"id":"https://openalex.org/C80446465","wikidata":"https://www.wikidata.org/wiki/Q412483","display_name":"Cholesterol side-chain cleavage enzyme","level":4,"score":0.9171575307846069},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.6532135605812073},{"id":"https://openalex.org/C2777703421","wikidata":"https://www.wikidata.org/wiki/Q15312538","display_name":"Steroidogenic factor 1","level":5,"score":0.5748197436332703},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5631994009017944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5406534075737},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45988520979881287},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4443493187427521},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4421643614768982},{"id":"https://openalex.org/C3020590458","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid biosynthesis","level":4,"score":0.4311252236366272},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3687867820262909},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.3542131781578064},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2918771207332611},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.29161208868026733},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.28472593426704407},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2585310637950897},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.23437362909317017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21523410081863403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14109796285629272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08657708764076233},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-101-5_7","doi":"https://doi.org/10.1007/978-1-59259-101-5_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-101-5_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adrenal Disorders","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W15176748","https://openalex.org/W55348468","https://openalex.org/W179357761","https://openalex.org/W1533192527","https://openalex.org/W1610204701","https://openalex.org/W1651094673","https://openalex.org/W1660177314","https://openalex.org/W1968624316","https://openalex.org/W1976472536","https://openalex.org/W2001591702","https://openalex.org/W2003129236","https://openalex.org/W2009443375","https://openalex.org/W2010287574","https://openalex.org/W2012639119","https://openalex.org/W2014909710","https://openalex.org/W2019771407","https://openalex.org/W2021994993","https://openalex.org/W2036495761","https://openalex.org/W2038435132","https://openalex.org/W2039490460","https://openalex.org/W2044738415","https://openalex.org/W2053497150","https://openalex.org/W2054637421","https://openalex.org/W2061819574","https://openalex.org/W2071047616","https://openalex.org/W2071521217","https://openalex.org/W2073715060","https://openalex.org/W2077861288","https://openalex.org/W2086314753","https://openalex.org/W2089269914","https://openalex.org/W2092880117","https://openalex.org/W2093013671","https://openalex.org/W2093373508","https://openalex.org/W2115541551","https://openalex.org/W2165101701","https://openalex.org/W2323979349"],"related_works":["https://openalex.org/W4475423","https://openalex.org/W1975363999","https://openalex.org/W2087979994","https://openalex.org/W190545265","https://openalex.org/W4231229169","https://openalex.org/W2064485183","https://openalex.org/W2076244912","https://openalex.org/W2920024106","https://openalex.org/W11111285","https://openalex.org/W1982425063"],"abstract_inverted_index":{"Steroid":[0],"hormones":[1,27,132],"produced":[2],"in":[3,22,28,67,73,115,128,196],"the":[4,23,33,44,56,60,83,89,95,109,116,123,157,162,197,209,227,265,273,281,295,302,308],"adrenals,":[5],"gonads,":[6],"and":[7,16,76,118,133,140,186,247,277,292,301],"placenta":[8],"are":[9],"important":[10],"regulators":[11],"of":[12,25,35,59,85,97,112,125,167,184,199,237],"tissue":[13,30],"differentiation,":[14],"development,":[15],"homeostasis.":[17],"The":[18,143],"first":[19,65],"committed":[20],"step":[21,66],"synthesis":[24,114,124],"these":[26],"all":[29],"types":[31],"is":[32,41,70,79,120,137,253,299],"conversion":[34],"cholesterol":[36,86],"into":[37],"pregnenolone.":[38],"This":[39,64,297],"reaction":[40],"catalyzed":[42],"by":[43,181,230,249,290,294],"cytochrome":[45],"P450":[46,98],"side-chain":[47],"cleavage":[48],"enzyme":[49,100],"(P450":[50],"scc":[51,99],")":[52],",":[53],"located":[54],"on":[55,264],"matrix":[57,91],"side":[58],"inner":[61,284],"mitochondrial":[62,267],"membrane.":[63,285],"steroidogenesis,":[68],"which":[69],"highly":[71],"regulated":[72],"a":[74,126,178,204],"temporal":[75],"tissue-specific":[77],"manner,":[78],"primarily":[80],"controlled":[81],"at":[82,94,226],"level":[84,96,229],"availability":[87],"to":[88,130,155,244,256,280],"inner-mitochondrial":[90],"rather":[92],"than":[93],"activity.":[101],"It":[102,259],"has":[103,241],"been":[104,242],"known":[105],"for":[106,161],"decades":[107],"that":[108,134,206,220,261],"acute":[110,163],"regulation":[111,198],"steroid-hormone":[113],"adrenals":[117],"gonads":[119],"dependent":[121],"upon":[122,208],"protein(s)":[127],"response":[129],"trophic":[131],"this":[135,251],"protein":[136,153,170,232],"fast-acting":[138],"(minutes)":[139],"functionally":[141],"short-lived.":[142],"recently":[144],"cloned":[145],"St":[146],"eroidogenic":[147],"A":[148,234],"cute":[149],"R":[150],"egulatory":[151],"(StAR)":[152],"appears":[154,260],"be":[156,245,305],"\u201clabile":[158],"protein\u201d":[159],"essential":[160,255],"steroidogenic":[164,214],"response.":[165],"Absence":[166],"functional":[168],"StAR":[169,200,224,240,257,262],"causes":[171],"congenital":[172],"lipoid":[173],"adrenal":[174,185],"hyperplasia":[175],"(lipoid":[176],"CAH),":[177],"disease":[179],"characterized":[180],"marked":[182],"impairment":[183],"gonadal":[187],"steroid":[188],"hormone":[189,212],"synthesis.":[190],"Recent":[191],"data":[192,218],"implicate":[193],"cAMP-mediated":[194,221],"pathways":[195,222],"mRNA":[201],"expression":[202],"via":[203],"mechanism":[205],"depends":[207],"orphan":[210],"nuclear":[211],"receptor,":[213],"factor-1":[215],"(SF-1).":[216],"Additional":[217],"suggest":[219],"stimulate":[223],"function":[225],"posttranslational":[228],"initiating":[231],"kinase":[233],"(PKA)-mediated":[235],"phosphorylation":[236],"StAR.":[238],"Although":[239],"shown":[243],"imported":[246],"processed":[248],"mitochondria,":[250],"event":[252],"not":[254,293],"function.":[258],"acts":[263],"outer":[266,275],"membrane,":[268],"stimulating":[269],"sterol":[270],"desorption":[271],"from":[272],"sterol-rich":[274],"membrane":[276],"its":[278],"transfer":[279],"relatively":[282],"sterol-poor":[283],"These":[286],"keywords":[287,303],"were":[288],"added":[289],"machine":[291],"authors.":[296],"process":[298],"experimental":[300],"may":[304],"updated":[306],"as":[307],"learning":[309],"algorithm":[310],"improves.":[311]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
