{"id":"https://openalex.org/W2182848815","doi":null,"title":"Contemporary Reviews in Cardiovascular Medicine Transthyretin (TTR) Cardiac Amyloidosis","display_name":"Contemporary Reviews in Cardiovascular Medicine Transthyretin (TTR) Cardiac Amyloidosis","publication_year":2016,"publication_date":"2016-09-21","ids":{"openalex":"https://openalex.org/W2182848815","mag":"2182848815"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.906.6276","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.906.6276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/126/10/1286.full.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005111256","display_name":"Frederick L. Ruberg","orcid":"https://orcid.org/0000-0002-6424-4413","observed_orcids":["https://orcid.org/0000-0002-6424-4413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederick L. Ruberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Md John","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md John","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L. Berk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Berk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00290592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloid-cardiomyopathy","display_name":"transthyretin amyloid cardiomyopathy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/systemic-amyloidosis","display_name":"systemic amyloidosis","score":0.875},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8650000095367432},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.9179999828338623},{"id":"https://openalex.org/keywords/congo-red-staining","display_name":"Congo red staining","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.4690000116825104},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9589999914169312},{"id":"https://openalex.org/keywords/amyloid-classification","display_name":"amyloid classification","score":0.7409999966621399},{"id":"https://openalex.org/keywords/amyloidosis-diagnosis","display_name":"amyloidosis diagnosis","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.9319517016410828},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.7548904418945312},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.7513843774795532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5828105807304382},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3988915681838989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3711426556110382}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.906.6276","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.906.6276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/126/10/1286.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W9156525","https://openalex.org/W30870368","https://openalex.org/W82787121","https://openalex.org/W233329042","https://openalex.org/W1494971749","https://openalex.org/W1585658616","https://openalex.org/W1648126347","https://openalex.org/W1870217140","https://openalex.org/W1965108537","https://openalex.org/W1972373816","https://openalex.org/W1972385206","https://openalex.org/W1975225251","https://openalex.org/W1978218208","https://openalex.org/W1980144587","https://openalex.org/W1981089609","https://openalex.org/W1983287291","https://openalex.org/W1986840808","https://openalex.org/W1987751618","https://openalex.org/W1989915275","https://openalex.org/W1990257840","https://openalex.org/W1991931070","https://openalex.org/W1992372883","https://openalex.org/W1994877692","https://openalex.org/W1997443563","https://openalex.org/W1997525726","https://openalex.org/W2001673252","https://openalex.org/W2001955317","https://openalex.org/W2003366387","https://openalex.org/W2004563081","https://openalex.org/W2004801645","https://openalex.org/W2005317100","https://openalex.org/W2005678387","https://openalex.org/W2011246655","https://openalex.org/W2013703514","https://openalex.org/W2015219413","https://openalex.org/W2016206253","https://openalex.org/W2020227153","https://openalex.org/W2020476622","https://openalex.org/W2026876267","https://openalex.org/W2032556980","https://openalex.org/W2033060908","https://openalex.org/W2035449193","https://openalex.org/W2040930230","https://openalex.org/W2042422752","https://openalex.org/W2042488860","https://openalex.org/W2046145754","https://openalex.org/W2046882226","https://openalex.org/W2047448176","https://openalex.org/W2048239090","https://openalex.org/W2050544577","https://openalex.org/W2050904540","https://openalex.org/W2052236321","https://openalex.org/W2053960009","https://openalex.org/W2060624358","https://openalex.org/W2064278776","https://openalex.org/W2067107777","https://openalex.org/W2069180940","https://openalex.org/W2071134058","https://openalex.org/W2074977475","https://openalex.org/W2078274541","https://openalex.org/W2079055620","https://openalex.org/W2081338080","https://openalex.org/W2084571556","https://openalex.org/W2084698716","https://openalex.org/W2085354241","https://openalex.org/W2085847118","https://openalex.org/W2086296057","https://openalex.org/W2086865872","https://openalex.org/W2087193980","https://openalex.org/W2088799509","https://openalex.org/W2089019006","https://openalex.org/W2089319585","https://openalex.org/W2089323357","https://openalex.org/W2092588827","https://openalex.org/W2094309420","https://openalex.org/W2094498076","https://openalex.org/W2094673093","https://openalex.org/W2098093182","https://openalex.org/W2100984427","https://openalex.org/W2101099004","https://openalex.org/W2101817311","https://openalex.org/W2102506290","https://openalex.org/W2103251680","https://openalex.org/W2107491044","https://openalex.org/W2109678074","https://openalex.org/W2111992555","https://openalex.org/W2112429383","https://openalex.org/W2117008792","https://openalex.org/W2117848442","https://openalex.org/W2118848299","https://openalex.org/W2118942953","https://openalex.org/W2122279069","https://openalex.org/W2124969108","https://openalex.org/W2127128200","https://openalex.org/W2128307213","https://openalex.org/W2128602522","https://openalex.org/W2129227455","https://openalex.org/W2136830554","https://openalex.org/W2144506100","https://openalex.org/W2151246487","https://openalex.org/W2151289840","https://openalex.org/W2158206316","https://openalex.org/W2161189819","https://openalex.org/W2162210749","https://openalex.org/W2162587223","https://openalex.org/W2165617204","https://openalex.org/W2167293860","https://openalex.org/W2167557203","https://openalex.org/W2169280166","https://openalex.org/W2226290316","https://openalex.org/W2314304229","https://openalex.org/W2336164784","https://openalex.org/W2505465812","https://openalex.org/W2558649598","https://openalex.org/W2749839293","https://openalex.org/W2900850603","https://openalex.org/W2915887121","https://openalex.org/W4240830553"],"related_works":["https://openalex.org/W3132332187","https://openalex.org/W4281666604","https://openalex.org/W2966138751","https://openalex.org/W3095461179","https://openalex.org/W4404064767","https://openalex.org/W3130635255","https://openalex.org/W4315432771","https://openalex.org/W1977307860","https://openalex.org/W4411286999","https://openalex.org/W4206689804"],"abstract_inverted_index":{"The":[0,41,103],"systemic":[1],"amyloidoses":[2],"are":[3,101],"a":[4,125],"family":[5],"of":[6,15,63,82,93,105,110],"diseases":[7],"inducedby":[8],"misfolded":[9],"or":[10,20],"misassembled":[11],"proteins.":[12],"Extracellular":[13],"deposition":[14],"these":[16],"proteins":[17,33],"as":[18],"soluble":[19],"insoluble":[21],"cross":[22],"-sheets":[23],"disrupts":[24],"vital":[25],"organ":[26],"function.1":[27],"More":[28],"than":[29],"27":[30],"different":[31],"precursor":[32,43],"have":[34],"the":[35,52,57,67,88],"propensity":[36],"to":[37,47],"form":[38,48],"amyloid":[39,49,53,64,89,111,117],"fibrils.2":[40],"particular":[42],"protein":[44],"that":[45],"misfolds":[46],"fibrils":[50],"defines":[51],"type":[54,90],"and":[55,73,79,91,98],"predicts":[56],"patient\u2019s":[58],"clinical":[59],"course.":[60],"Several":[61],"types":[62],"can":[65],"infil-trate":[66],"heart,":[68],"resulting":[69],"in":[70],"progressive":[71],"diastolic":[72],"systolic":[74],"dysfunction,":[75],"congestive":[76],"heart":[77],"failure,":[78],"death.":[80],"Treatment":[81],"cardiac":[83],"amyloidosis":[84,106],"is":[85],"dictated":[86],"by":[87,121],"degree":[92],"involvement.":[94],"Consequently,":[95],"early":[96],"recognition":[97],"accurate":[99],"classification":[100],"essential.3":[102],"diagnosis":[104],"requires":[107],"histological":[108],"identi-fication":[109],"deposits.":[112],"Congo":[113],"Red":[114],"staining":[115],"renders":[116],"deposits":[118],"salmon":[119],"pink":[120],"light":[122],"microscopy,":[123],"with":[124]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}