{"id":"https://openalex.org/W2182783239","doi":null,"title":"The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice.","display_name":"The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2182783239","mag":"2182783239","pmid":"https://pubmed.ncbi.nlm.nih.gov/23811455"},"language":"en","primary_location":{"id":"pmid:23811455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23811455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028581738","display_name":"Chuan Zhou","orcid":"https://orcid.org/0000-0002-2919-3593","observed_orcids":["https://orcid.org/0000-0002-2919-3593"]},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan Zhou","raw_affiliation_strings":["College of Veterinary Medicine, Shandong Agricultural University, Tai`an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Shandong Agricultural University, Tai`an, China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Youfei Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youfei Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029984161","display_name":"Jinlian Li","orcid":"https://orcid.org/0000-0003-4304-8058","observed_orcids":["https://orcid.org/0000-0003-4304-8058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinlian Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074042037","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0003-0821-7143","observed_orcids":["https://orcid.org/0000-0003-0821-7143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100655006","display_name":"Yanmin Wang","orcid":"https://orcid.org/0009-0005-2928-9818","observed_orcids":["https://orcid.org/0009-0005-2928-9818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanmin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351091","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-5955-3326","observed_orcids":["https://orcid.org/0000-0002-5955-3326","https://orcid.org/0000-0001-6868-5454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066122148","display_name":"Jianzhu Liu","orcid":"https://orcid.org/0000-0003-3634-0712","observed_orcids":["https://orcid.org/0000-0003-3634-0712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianzhu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9499,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.77332018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"26","issue":"4","first_page":"761","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurochenodeoxycholic-acid","display_name":"taurochenodeoxycholic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tgr5","display_name":"TGR5","score":0.996999979019165},{"id":"https://openalex.org/keywords/bile-acid-receptors","display_name":"bile acid receptors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-fibrosis-prevention","display_name":"lung fibrosis prevention","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.8400248289108276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7943631410598755},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7704144716262817},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6202741861343384},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.5262075066566467},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43025699257850647},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4294111728668213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42248067259788513},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36191055178642273},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33668601512908936},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.05672156810760498}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013655","descriptor_name":"Taurochenodeoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013655","descriptor_name":"Taurochenodeoxycholic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23811455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23811455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:2182783239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23811455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1966362965","https://openalex.org/W2017362076","https://openalex.org/W2035391709","https://openalex.org/W2050228005","https://openalex.org/W2067834397","https://openalex.org/W2081028309","https://openalex.org/W2090298778","https://openalex.org/W2096418655","https://openalex.org/W2112644387","https://openalex.org/W2118593948","https://openalex.org/W2121901734","https://openalex.org/W2125524268","https://openalex.org/W2165877587","https://openalex.org/W2172628686","https://openalex.org/W2315085844","https://openalex.org/W2366091307"],"related_works":["https://openalex.org/W2577842469","https://openalex.org/W417401560","https://openalex.org/W3158282581","https://openalex.org/W7215028417","https://openalex.org/W2387375755","https://openalex.org/W2063025076","https://openalex.org/W3022419926","https://openalex.org/W7203763437","https://openalex.org/W2734643730","https://openalex.org/W1867803947"],"abstract_inverted_index":{"The":[0,66,169],"present":[1],"study":[2],"prepared":[3],"the":[4,16,19,34,39,76,79,92,96,108,112,125,136,147,152],"pulmonary":[5,27,49,63,93,109,144,148,181],"fibrosis":[6,28,64,149,182],"model":[7,97,113],"in":[8,25,29,38,62,75,82,95,101,111,117,143,146,183],"mice":[9,42,98,114,150],"by":[10],"using":[11],"Bleomycin":[12],"and":[13,44,48,60,71,86,121,141],"carry":[14],"out":[15],"investigations":[17],"on":[18,128,167,180],"effects":[20,166],"of":[21,33,41,56,78,84,104,119,139,155],"taurochenodeoxycholic":[22],"acid":[23,36],"(TCDCA)":[24],"preventing":[26],"mice.":[30,65,184],"Expression":[31],"profiles":[32],"bile":[35],"receptors":[37],"lung":[40,77],"FXR\u03b1":[43,70],"TGR5":[45,72],"were":[46],"examined,":[47],"coefficient,":[50],"pathohistology":[51],"as":[52,54,171],"well":[53],"expression":[55,137,153],"TNF-\u03b1,":[57],"MMP-2,":[58],"MMP-9":[59,156],"TIMP-2":[61,142],"results":[67,170],"showed":[68],"that":[69,175],"simultaneously":[73],"expressed":[74],"mice;":[80],"TCDCA":[81,100,116,131,176],"dosages":[83,118],"0.05":[85,120],"0.1g/kg":[87,122],"can":[88,132],"extremely":[89,133,157],"significantly":[90,106,123,134,158],"decrease":[91,135],"coefficient":[94,110],"(P>0.01),":[99,151,160],"a":[102],"dosage":[103],"0.2g/kg":[105],"decreased":[107],"(P<0.05);":[115],"reduce":[124],"pathological":[126],"damages":[127],"their":[129],"lungs;":[130],"levels":[138],"TNF-\u03b1":[140],"tissues":[145],"level":[154],"increased":[159],"while":[161],"it":[162],"has":[163],"no":[164],"significant":[165],"MMP2.":[168],"mentioned":[172],"above":[173],"indicated":[174],"had":[177],"antagonistic":[178],"actions":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}