{"id":"https://openalex.org/W2182768463","doi":null,"title":"Dose-intensive versus dose-control chemotherapy for high-grade osteosarcoma: a meta-analysis.","display_name":"Dose-intensive versus dose-control chemotherapy for high-grade osteosarcoma: a meta-analysis.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182768463","mag":"2182768463","pmid":"https://pubmed.ncbi.nlm.nih.gov/24867518"},"language":"en","primary_location":{"id":"pmid:24867518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24867518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102973493","display_name":"W Wang","orcid":"https://orcid.org/0000-0001-6849-1406","observed_orcids":["https://orcid.org/0000-0001-6849-1406"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W Wang","raw_affiliation_strings":["Department of Orhtopaedic, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. luhuahawk@hotmail.com","Department of Orhtopaedic, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orhtopaedic, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. luhuahawk@hotmail.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]},{"raw_affiliation_string":"Department of Orhtopaedic, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103586683","display_name":"Wang Zc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z-c Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001027254","display_name":"Hong Shen","orcid":"https://orcid.org/0000-0002-6456-8231","observed_orcids":["https://orcid.org/0000-0002-6456-8231","https://orcid.org/0000-0003-0593-7268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110281274","display_name":"JJ Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J-j Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"H Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3274,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60020235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"18","issue":"9","first_page":"1383","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-osteosarcoma","display_name":"high-grade osteosarcoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dose-intensive-chemotherapy","display_name":"dose-intensive chemotherapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7089999914169312},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.9909999966621399},{"id":"https://openalex.org/keywords/histological-response","display_name":"histological response","score":0.9150000214576721},{"id":"https://openalex.org/keywords/limb-salvage","display_name":"limb salvage","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.832065224647522},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6990259289741516},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6197207570075989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6034430861473083},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6016241908073425},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5914342999458313},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.5195205807685852},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.48202598094940186},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4692299962043762},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45975542068481445},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4153737425804138},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3413294553756714},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3354286551475525},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2945461869239807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15123996138572693}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023821","descriptor_name":"Limb Salvage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24867518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24867518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2182768463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24867518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W133663130","https://openalex.org/W1572032963","https://openalex.org/W1606259773","https://openalex.org/W1854116296","https://openalex.org/W1911184691","https://openalex.org/W1946181835","https://openalex.org/W1975737843","https://openalex.org/W1980569034","https://openalex.org/W2004186414","https://openalex.org/W2044332600","https://openalex.org/W2064448871","https://openalex.org/W2104953667","https://openalex.org/W2116042827","https://openalex.org/W2142136189","https://openalex.org/W2163165105","https://openalex.org/W2222995977","https://openalex.org/W2317312402","https://openalex.org/W2329218644","https://openalex.org/W2401288785","https://openalex.org/W2412345546","https://openalex.org/W2470208521","https://openalex.org/W2474479097","https://openalex.org/W4302043507"],"related_works":["https://openalex.org/W2053154199","https://openalex.org/W2396199921","https://openalex.org/W2803646058","https://openalex.org/W1965013501","https://openalex.org/W2236772154","https://openalex.org/W2063655127","https://openalex.org/W2050113647","https://openalex.org/W1993585353","https://openalex.org/W2070248730","https://openalex.org/W2063282481"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tumor":[1],"necrosis":[2],"might":[3,219],"be":[4,221,244],"a":[5,36,222],"consequence":[6],"of":[7,10,17,21,26,52,200,227,241],"innate":[8],"sensitivity":[9],"tumor":[11],"cells":[12],"to":[13],"changed":[14],"dosage":[15,20,240],"instead":[16],"the":[18,24,53,114,120,137,141,183,194,201,228],"increased":[19],"chemotherapeutics":[22],"in":[23,119,145,236,246],"treatment":[25,38,224],"osteosarcoma":[27,45,110,230],"patients.":[28,46,231],"AIM:":[29],"To":[30],"explore":[31],"whether":[32],"dose-intensive":[33,138,237],"regimen":[34,218],"was":[35,56,63,132],"better":[37],"method":[39],"than":[40],"dose-control":[41],"chemotherapy":[42,242],"for":[43,82,225],"high-grade":[44,109,229],"MATERIALS":[47],"AND":[48],"METHODS:":[49],"The":[50,127],"data":[51],"included":[54,115],"studies":[55,104,116],"analyzed":[57],"by":[58,66],"random-effects":[59],"model":[60],"when":[61],"there":[62,131,233],"heterogeneity,":[64],"otherwise":[65],"fixed-effects":[67],"method.":[68,126],"Meta-analysis":[69],"outcomes":[70],"were":[71,111,117,213,234],"calculated":[72],"as":[73],"risk":[74],"ratio":[75],"(RR)":[76],"and":[77,98,124,140,193,203],"95%":[78,153,162,171,179,189,209],"confidence":[79],"interval":[80],"(CI)":[81],"5-year":[83,88,146,156,195],"disease":[84,147,196],"free":[85,148,197],"survival":[86,149,158,198],"rate,":[87,93],"overall":[89,157],"survival,":[90],"local":[91,184],"recurrence":[92,185],"good":[94,165,202],"histological":[95,166,205],"response":[96,167,206],"rate":[97,150,159,168,176,186,199],"Limb":[99],"salvage":[100,175],"rate.":[101],"RESULTS:":[102],"Five":[103],"involving":[105],"1434":[106],"patients":[107],"with":[108],"included.":[112],"All":[113],"inadequate":[118],"information":[121],"about":[122],"randomization":[123],"blinding":[125],"meta-analysis":[128],"showed":[129],"that":[130],"no":[133],"significant":[134],"difference":[135],"between":[136],"group":[139,144],"dose":[142],"control":[143],"(RR:":[151,160,169,177,187,207],"1.08,":[152,170],"CI:":[154,163,172,180,190,210],"0.96-1.21),":[155],"1.07,":[161],"0.98-1.17),":[164],"0.82-1.43),":[173],"limb":[174],"0.97,":[178],"0.93-1.02).":[181],"However,":[182],"0.65,":[188],"0.46-":[191],"0.92)":[192],"poor":[204],"1.57,":[208],"1.36-":[211],"1.82)":[212],"significantly":[214],"different.":[215],"CONCLUSIONS:":[216],"Dose-intensive":[217],"not":[220],"preferred":[223],"all":[226],"Although":[232],"advantages":[235],"regimen,":[238],"appropriate":[239],"should":[243],"considered":[245],"clinical":[247],"cases.":[248]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
