{"id":"https://openalex.org/W2182696941","doi":null,"title":"The role of serendipity in the discovery of the clinical effects of psychotropic drugs: beyond of the myth.","display_name":"The role of serendipity in the discovery of the clinical effects of psychotropic drugs: beyond of the myth.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2182696941","mag":"2182696941","pmid":"https://pubmed.ncbi.nlm.nih.gov/22344494"},"language":"en","primary_location":{"id":"pmh:oai:actaspsiquiatria.es:article/541","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/541","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/541/799","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://actaspsiquiatria.es/index.php/actas/article/download/541/799","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065965614","display_name":"Francisco Javier Lopez-Munoz","orcid":"https://orcid.org/0000-0002-5188-6038","observed_orcids":["https://orcid.org/0000-0002-5188-6038"]},"institutions":[{"id":"https://openalex.org/I59946547","display_name":"Camilo Jos\u00e9 Cela University","ror":"https://ror.org/03f6h9044","country_code":"ES","type":"education","lineage":["https://openalex.org/I59946547"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco L\u00f3pez-Mu\u00f1oz","raw_affiliation_strings":["Pharmacology Department, Universidad Camilo Jos\u00e9 Cela, Madrid, Spain. francisco.lopez.munoz@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Universidad Camilo Jos\u00e9 Cela, Madrid, Spain. francisco.lopez.munoz@gmail.com","institution_ids":["https://openalex.org/I59946547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111512328","display_name":"Alan A. Baumeister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan A Baumeister","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024481284","display_name":"Mike F. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike F Hawkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034044460","display_name":"Cecilio \u00c1lamo","orcid":"https://orcid.org/0000-0001-7652-7931","observed_orcids":["https://orcid.org/0000-0001-7652-7931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilio Alamo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0776,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.74182044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"1","first_page":"34","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12666","display_name":"Historical Psychiatry and Medical Practices","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serendipity","display_name":"serendipity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/psychotropic-drugs","display_name":"psychotropic drugs","score":0.7850000262260437},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.9409999847412109},{"id":"https://openalex.org/keywords/history-of-psychopharmacology","display_name":"history of psychopharmacology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9129999876022339},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.9929999709129333},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lithium-salts","display_name":"lithium salts","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/meprobamate","display_name":"meprobamate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/clinical-utility","display_name":"clinical utility","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2779119418","wikidata":"https://www.wikidata.org/wiki/Q166039","display_name":"Serendipity","level":2,"score":0.9446755647659302},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.506173312664032},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.4609414339065552},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43302592635154724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3176538050174713},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1986762285232544},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.19154366850852966},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.15467503666877747},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10463759303092957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011600","descriptor_name":"Psychopharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:actaspsiquiatria.es:article/541","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/541","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/541/799","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:22344494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22344494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Actas espanolas de psiquiatria","raw_type":"Journal Article"},{"id":"pmh:oai:repository.lsu.edu:psychology_pubs-3356","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/psychology_pubs/2356","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"mag:2182696941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22344494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:actaspsiquiatria.es:article/541","doi":null,"is_oa":true,"landing_page_url":"https://actaspsiquiatria.es/index.php/actas/article/view/541","pdf_url":"https://actaspsiquiatria.es/index.php/actas/article/download/541/799","source":{"id":"https://openalex.org/S167709542","display_name":"Actas Espa\u00f1olas de Psiquiatr\u00eda","issn_l":"1139-9287","issn":["1139-9287","1578-2735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4365328534","host_organization_name":"Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor","host_organization_lineage":["https://openalex.org/P4365328534"],"host_organization_lineage_names":["Fundaci\u00f3n Juan Jos\u00e9 L\u00f3pez-Ibor"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1139-9287","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2182696941.pdf","grobid_xml":"https://content.openalex.org/works/W2182696941.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W23891683","https://openalex.org/W36248138","https://openalex.org/W61954186","https://openalex.org/W74091539","https://openalex.org/W85128241","https://openalex.org/W563753301","https://openalex.org/W641729291","https://openalex.org/W645199439","https://openalex.org/W1554893731","https://openalex.org/W1566289480","https://openalex.org/W1605017372","https://openalex.org/W1697749966","https://openalex.org/W1969301080","https://openalex.org/W1981420116","https://openalex.org/W1983689352","https://openalex.org/W1985687675","https://openalex.org/W2003237841","https://openalex.org/W2004823323","https://openalex.org/W2037148595","https://openalex.org/W2052164879","https://openalex.org/W2061954678","https://openalex.org/W2062514454","https://openalex.org/W2084464922","https://openalex.org/W2087602255","https://openalex.org/W2093036934","https://openalex.org/W2094466360","https://openalex.org/W2100641180","https://openalex.org/W2121713405","https://openalex.org/W2125249259","https://openalex.org/W2144312659","https://openalex.org/W2159996636","https://openalex.org/W2209785018","https://openalex.org/W2239549768","https://openalex.org/W2326523421","https://openalex.org/W2328138439","https://openalex.org/W2416063624","https://openalex.org/W2970068256","https://openalex.org/W2999952571","https://openalex.org/W3014564955","https://openalex.org/W3119918057","https://openalex.org/W3194208160"],"related_works":["https://openalex.org/W7216994807","https://openalex.org/W7096621955","https://openalex.org/W2154708789","https://openalex.org/W4223589694","https://openalex.org/W1997829197","https://openalex.org/W2075807703","https://openalex.org/W2155663962","https://openalex.org/W2302317683","https://openalex.org/W4396716510","https://openalex.org/W2029266969"],"abstract_inverted_index":{"The":[0,81],"serendipity":[1,19,59],"is":[2,169],"the":[3,18,25,47,62,73,78,91,170],"faculty":[4],"for":[5],"making":[6],"a":[7,10,21,120,152,162],"discovery":[8,26,63,164],"through":[9],"combination":[11],"of":[12,27,49,58,64,72,88,93,165,172],"accident":[13],"and":[14],"sagacity.":[15],"In":[16],"psychopharmacology,":[17],"played":[20],"key":[22],"role":[23],"in":[24,36,44,90,142],"many":[28],"psychotropic":[29],"drugs,":[30],"although":[31],"there":[32,104],"are":[33,145],"marked":[34],"disputes":[35],"this":[37,50,102,143],"regard,":[38],"possibly":[39],"due":[40],"to":[41,46,77,96,119,161],"semantic":[42],"differences":[43],"relation":[45],"meaning":[48],"term.":[51],"We":[52,135],"have":[53],"implemented":[54],"an":[55,155],"operational":[56],"definition":[57],"based":[60],"on":[61],"something":[65],"unexpected":[66],"or":[67,177],"not":[68,146],"sought":[69],"intentionally,":[70],"irrespective":[71],"systematic":[74],"process":[75],"leading":[76,118],"accidental":[79],"observation.":[80],"present":[82],"paper":[83],"analyses":[84],"some":[85],"representative":[86],"examples":[87],"discoveries":[89,113,122,125,133,141],"field":[92,144],"psychopharmacology":[94],"according":[95],"different":[97,108],"serendipitous":[98,112,116,129,140,157],"intervention":[99],"patterns.":[100],"Following":[101],"approach":[103],"would":[105],"be":[106],"four":[107],"imputability":[109],"patterns:":[110],"pure":[111,139],"(valproic":[114],"acid/valproate);":[115],"observation":[117,130,158],"non-serendipitous":[121,124,132,163],"(imipramine);":[123],"secondarily":[126],"associated":[127],"with":[128],"(barbiturates);":[131],"(haloperidol).":[134],"can":[136],"conclude":[137],"that":[138],"very":[147],"frequent,":[148],"most":[149],"common":[150],"being":[151],"mixed":[153],"pattern;":[154],"initial":[156],"which":[159],"leads":[160],"clinical":[166],"utility.":[167],"This":[168],"case":[171],"imipramine,":[173],"lithium":[174],"salts,":[175],"chlorpromazine":[176],"meprobamate.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}