{"id":"https://openalex.org/W2182641452","doi":"https://doi.org/10.37285/ijpsn.2010.3.4.13","title":"Renoprotective Effects of Combined Aliskiren and Valsartan in Progressive Diabetic Nephropathy in Rats","display_name":"Renoprotective Effects of Combined Aliskiren and Valsartan in Progressive Diabetic Nephropathy in Rats","publication_year":2011,"publication_date":"2011-02-28","ids":{"openalex":"https://openalex.org/W2182641452","doi":"https://doi.org/10.37285/ijpsn.2010.3.4.13","mag":"2182641452"},"language":"en","primary_location":{"id":"doi:10.37285/ijpsn.2010.3.4.13","doi":"https://doi.org/10.37285/ijpsn.2010.3.4.13","is_oa":false,"landing_page_url":"https://doi.org/10.37285/ijpsn.2010.3.4.13","pdf_url":null,"source":{"id":"https://openalex.org/S4210168318","display_name":"International Journal of Pharmaceutical Sciences and Nanotechnology","issn_l":"0974-3278","issn":["0974-3278"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088986081","display_name":"Vidya Sagar Jenugu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vidya Sagar Jenugu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032514523","display_name":"Hemanth Kumar Nyathani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hemanth Kumar Nyathani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111999359","display_name":"Srirangam Prashanth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashanth Srirangam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069119836","display_name":"Krishna Mohan Chinnala","orcid":"https://orcid.org/0000-0001-7218-6877","observed_orcids":["https://orcid.org/0000-0001-7218-6877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishna Mohan Chinnala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088986081"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"1276","last_page":"1286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0737999975681305,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aliskiren","display_name":"aliskiren","score":0.9129999876022339},{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":1.0},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9229999780654907},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9330000281333923},{"id":"https://openalex.org/keywords/renin-inhibitors","display_name":"renin inhibitors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.984000027179718},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/monotherapy-comparison","display_name":"monotherapy comparison","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779838083","wikidata":"https://www.wikidata.org/wiki/Q414904","display_name":"Aliskiren","level":4,"score":0.9760692119598389},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.9624065160751343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7945495843887329},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.7318958640098572},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5732186436653137},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.570565938949585},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5428961515426636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5036272406578064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4803829789161682},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.47639766335487366},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4544719159603119},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44665735960006714},{"id":"https://openalex.org/C2780708007","wikidata":"https://www.wikidata.org/wiki/Q285044","display_name":"Angiotensin II receptor antagonist","level":5,"score":0.43429306149482727},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.40961235761642456},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3890872001647949},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.35918521881103516},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2014552354812622},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10888773202896118}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.37285/ijpsn.2010.3.4.13","doi":"https://doi.org/10.37285/ijpsn.2010.3.4.13","is_oa":false,"landing_page_url":"https://doi.org/10.37285/ijpsn.2010.3.4.13","pdf_url":null,"source":{"id":"https://openalex.org/S4210168318","display_name":"International Journal of Pharmaceutical Sciences and Nanotechnology","issn_l":"0974-3278","issn":["0974-3278"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutical Sciences and Nanotechnology","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.ijpsn.araijournal.com:article/546","doi":null,"is_oa":false,"landing_page_url":"https://ijpsnonline.com/index.php/ijpsn/article/view/546","pdf_url":null,"source":{"id":"https://openalex.org/S4210168318","display_name":"International Journal of Pharmaceutical Sciences and Nanotechnology","issn_l":"0974-3278","issn":["0974-3278"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0974-3278","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2185192485","doi":null,"is_oa":false,"landing_page_url":"https://www.globalresearchonline.net/journalcontents/volume6issue2/Article-028.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W71275700","https://openalex.org/W1511912213","https://openalex.org/W1964920299","https://openalex.org/W1980194826","https://openalex.org/W1991088354","https://openalex.org/W2008494063","https://openalex.org/W2040961193","https://openalex.org/W2067958701","https://openalex.org/W2118230918","https://openalex.org/W2122088193","https://openalex.org/W2140429097","https://openalex.org/W2145632481","https://openalex.org/W2154098294","https://openalex.org/W2164792647","https://openalex.org/W2319117583","https://openalex.org/W2337738945","https://openalex.org/W2340171512"],"related_works":["https://openalex.org/W2185192485","https://openalex.org/W2117703887","https://openalex.org/W2008494063","https://openalex.org/W1026709408","https://openalex.org/W1991088354","https://openalex.org/W2014755130","https://openalex.org/W2086385213","https://openalex.org/W2035357682","https://openalex.org/W2914627019","https://openalex.org/W2095544263"],"abstract_inverted_index":{"Renin":[0],"angiotensin":[1,30],"system":[2],"plays":[3],"a":[4],"major":[5],"role":[6],"in":[7,43,113],"the":[8,15,18,111],"pathology":[9],"of":[10,21,67,103],"progressive":[11,114],"Diabetic":[12],"Nephropathy.":[13],"In":[14],"present":[16],"study,":[17],"renoprotective":[19],"effects":[20],"low":[22],"dose":[23],"combined":[24],"novel":[25],"direct":[26],"renin":[27],"inhibitor-aliskiren":[28],"and":[29,39,65,69,81,92,105],"II":[31],"type":[32],"1":[33],"receptor":[34],"blocker":[35],"(ARB)-valsartan":[36],"were":[37,47,90],"estimated":[38,91],"compared":[40,93],"with":[41,58],"monotherapy":[42,112],"wistar":[44],"rats.":[45,97],"Rats":[46],"divided":[48],"into":[49],"5":[50],"groups:":[51],"control,":[52,54],"diabetic":[53,55,96,115],"rats":[56],"treated":[57],"aliskiren":[59,68,104],"(10":[60],"mg/kg/day),":[61],"valsartan":[62,70,106],"(20":[63],"mg/kg/day)":[64],"combination":[66,101],"(5":[71],"mg/kg/day,":[72],"10mg/kg/day":[73],"respectively).":[74],"Clinical":[75],"characteristics":[76],"like":[77,85],"proteinuria,":[78],"serum":[79],"creatinine":[80],"renal":[82],"histopathological":[83],"studies":[84],"glomerulosclrotic":[86],"index,":[87],"tubulointerstitial":[88],"fibrosis":[89],"between":[94],"all":[95],"Results":[98],"showed":[99],"that":[100],"therapy":[102],"was":[107],"more":[108],"effective":[109],"than":[110],"nephropathy.":[116]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}