{"id":"https://openalex.org/W2182608264","doi":null,"title":"Alzheimer 's disease - Recent Advancement in Neuroscience Research","display_name":"Alzheimer 's disease - Recent Advancement in Neuroscience Research","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2182608264","mag":"2182608264"},"language":"en","primary_location":{"id":"mag:2182608264","doi":null,"is_oa":false,"landing_page_url":"http://www.ijpbs.com/ijpbsadmin/upload/ijpbs_518104e9b47b2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054531525","display_name":"Salahuddin Mohammed","orcid":"https://orcid.org/0000-0001-7306-5989","observed_orcids":["https://orcid.org/0000-0001-7306-5989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salahuddin Mohammed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7306-5989","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007796948","display_name":"Demissew Berihun Haile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demissew Berihun Haile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.796999990940094},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8709999918937683},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.921999990940094},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6330000162124634},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/active-immunization","display_name":"active immunization","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-secretase-inhibitors","display_name":"beta-secretase inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathophysiology","display_name":"Alzheimer's disease pathophysiology","score":0.7730000019073486},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.9137407541275024},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7249826788902283},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6429683566093445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6213881373405457},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5841754674911499},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5814418792724609},{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.5644007325172424},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.48729050159454346},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.40898773074150085},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.300733745098114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13916531205177307}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182608264","doi":null,"is_oa":false,"landing_page_url":"http://www.ijpbs.com/ijpbsadmin/upload/ijpbs_518104e9b47b2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W161331126","https://openalex.org/W166560457","https://openalex.org/W185590523","https://openalex.org/W1585653286","https://openalex.org/W1868333091","https://openalex.org/W1973637060","https://openalex.org/W1988892584","https://openalex.org/W1990587638","https://openalex.org/W2000917982","https://openalex.org/W2004838625","https://openalex.org/W2018692335","https://openalex.org/W2024287605","https://openalex.org/W2039069312","https://openalex.org/W2044055673","https://openalex.org/W2044885817","https://openalex.org/W2051277736","https://openalex.org/W2052742260","https://openalex.org/W2054648295","https://openalex.org/W2061769482","https://openalex.org/W2076425653","https://openalex.org/W2080503418","https://openalex.org/W2082785772","https://openalex.org/W2083880873","https://openalex.org/W2096410114","https://openalex.org/W2106931873","https://openalex.org/W2111447975","https://openalex.org/W2129267808","https://openalex.org/W2131266318","https://openalex.org/W2131406087","https://openalex.org/W2132365933","https://openalex.org/W2133239607","https://openalex.org/W2137777161","https://openalex.org/W2146729934","https://openalex.org/W2156220037","https://openalex.org/W2159011576","https://openalex.org/W2326200998"],"related_works":["https://openalex.org/W7099801776","https://openalex.org/W2341061248","https://openalex.org/W2393886254","https://openalex.org/W2256450022","https://openalex.org/W2625605244","https://openalex.org/W2053599215","https://openalex.org/W2013711762","https://openalex.org/W1969793439","https://openalex.org/W2581596104","https://openalex.org/W2286153362"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,21,105,130,136,152],"disease":[1,22,67,137,153],"also":[2],"known":[3],"as":[4],"dementia":[5],"is":[6,138],"one":[7],"of":[8,29,36,65,104,129,135,151,179],"the":[9,34,56,63,66,149,156,163],"widely":[10],"affective":[11],"neurodegenerative":[12],"disorder":[13],"only":[14],"after":[15],"Parkinsonism.":[16],"The":[17,47,85,107,132],"patients":[18],"suffering":[19],"from":[20],"has":[23,32,74,116,144],"increased":[24],"dramatically":[25],"over":[26],"a":[27],"period":[28],"time.":[30],"This":[31,72],"propelled":[33],"interest":[35],"neuroscientists":[37],"to":[38,43,126],"develop":[39],"new":[40],"drug":[41,109],"therapies":[42],"combat":[44],"this":[45],"disease.":[46,106,131],"drugs":[48],"available":[49],"are":[50,94],"not":[51,139],"effective":[52,59,96,118],"in":[53,60,97,119,124,148,161],"permanently":[54],"curing":[55],"disease,":[57],"but":[58],"mostly":[61],"reducing":[62],"symptoms":[64],"and":[68,82,101,171,177,181],"delaying":[69],"its":[70],"progression.":[71],"review":[73],"been":[75,117,145],"produced":[76],"by":[77],"probing":[78],"relevant":[79],"publications,":[80],"PubMed":[81],"Medline":[83],"articles.":[84],"Pharmacotherapy":[86],"revolves":[87],"around":[88],"two":[89],"drugs,":[90],"Acetylcholinesterase":[91,122],"Inhibitors":[92,123],"which":[93,115,154,168],"most":[95,164],"treating":[98],"mild,":[99],"moderate":[100,125],"severe":[102,127],"form":[103,128],"other":[108],"being":[110],"Memantine,":[111],"NMDA":[112],"receptor":[113],"antagonist":[114],"combination":[120],"with":[121],"underlying":[133],"pathophysiology":[134,150],"very":[140],"clear.":[141],"Contemporarily":[142],"there":[143],"alarming":[146],"advancements":[147],"provided":[155],"gateway":[157],"for":[158],"neuroscience":[159],"research":[160],"determining":[162],"favourable":[165],"investigational":[166],"treatments":[167],"includes":[169],"Passive":[170],"Active":[172],"immunization":[173],"techniques":[174],"against":[175],"Amyloid-\u03b2-protein":[176],"development":[178],"\u03b2":[180],"\u03b3":[182],"secretase":[183],"inhibitors.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}