{"id":"https://openalex.org/W2182534951","doi":null,"title":"A cross-sectional analysis of the RISC Study","display_name":"A cross-sectional analysis of the RISC Study","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2182534951","mag":"2182534951"},"language":"en","primary_location":{"id":"mag:2182534951","doi":null,"is_oa":false,"landing_page_url":"https://care.diabetesjournals.org/content/early/2013/10/08/dc13-0682.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066887782","display_name":"Simona Baldi","orcid":"https://orcid.org/0000-0002-8296-4238","observed_orcids":["https://orcid.org/0000-0002-8296-4238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Baldi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8296-4238","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086902696","display_name":"Fabrice Bonnet","orcid":"https://orcid.org/0000-0001-9255-8228","observed_orcids":["https://orcid.org/0000-0001-9255-8228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabrice Bonnet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9255-8228","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022873565","display_name":"Martine Laville","orcid":"https://orcid.org/0000-0002-6252-9853","observed_orcids":["https://orcid.org/0000-0002-6252-9853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martine Laville","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063930428","display_name":"Cecilia Morgantini","orcid":"https://orcid.org/0000-0003-3142-2508","observed_orcids":["https://orcid.org/0000-0003-3142-2508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Morgantini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3142-2508","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788538","display_name":"Lucilla Domenica Monti","orcid":"https://orcid.org/0000-0002-4285-8588","observed_orcids":["https://orcid.org/0000-0002-4285-8588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucilla D. Monti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4285-8588","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039949303","display_name":"Kurt H\u00f8jlund","orcid":"https://orcid.org/0000-0002-0891-4224","observed_orcids":["https://orcid.org/0000-0002-0891-4224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kurt H\u00f8jlund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0891-4224","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089847244","display_name":"Ele Ferrannini","orcid":"https://orcid.org/0000-0002-1384-1584","observed_orcids":["https://orcid.org/0000-0002-1384-1584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ele Ferrannini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1384-1584","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055458112","display_name":"Andrea Natali","orcid":"https://orcid.org/0000-0002-8465-7717","observed_orcids":["https://orcid.org/0000-0002-8465-7717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Natali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8465-7717","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.972000002861023},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9549999833106995},{"id":"https://openalex.org/keywords/apolipoproteins","display_name":"apolipoproteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9279999732971191},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9430000185966492},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9729999899864197},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.7710000276565552},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7824077010154724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.773644208908081},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.6494898200035095},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6025912761688232},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.590300440788269},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5399205088615417},{"id":"https://openalex.org/C2780745583","wikidata":"https://www.wikidata.org/wiki/Q1316030","display_name":"Apolipoprotein A1","level":4,"score":0.5146811604499817},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5139989256858826},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4794372618198395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44778475165367126},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4130290150642395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4129367470741272}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182534951","doi":null,"is_oa":false,"landing_page_url":"https://care.diabetesjournals.org/content/early/2013/10/08/dc13-0682.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1979684127","https://openalex.org/W1997978122","https://openalex.org/W2025242285","https://openalex.org/W2029164903","https://openalex.org/W2029571455","https://openalex.org/W2029667684","https://openalex.org/W2033590944","https://openalex.org/W2044425736","https://openalex.org/W2045250131","https://openalex.org/W2078271916","https://openalex.org/W2091797611","https://openalex.org/W2094786339","https://openalex.org/W2096432979","https://openalex.org/W2100051251","https://openalex.org/W2102782957","https://openalex.org/W2105912552","https://openalex.org/W2113765208","https://openalex.org/W2121441725","https://openalex.org/W2123484480","https://openalex.org/W2125103697","https://openalex.org/W2125644926","https://openalex.org/W2140221451","https://openalex.org/W2143340286","https://openalex.org/W2149360342","https://openalex.org/W2165534314"],"related_works":["https://openalex.org/W1964912832","https://openalex.org/W7093828373","https://openalex.org/W3156565034","https://openalex.org/W4378649302","https://openalex.org/W4281666496","https://openalex.org/W2120886148","https://openalex.org/W2045250131","https://openalex.org/W2108494065","https://openalex.org/W2332827649","https://openalex.org/W1592022330"],"abstract_inverted_index":{"OBJECTIVEdWe":[0],"evaluated":[1],"whether":[2],"the":[3,32,73,201,232],"association":[4,142],"of":[5,31,158,203,235],"insulin":[6,183,206],"sensitivity":[7,56,184,207],"with":[8,95,143,161,165],"HDL":[9,100,148,180],"cholesterol":[10,149,181],"(HDL)":[11],"and":[12,49,76,81,89,101,120,138,150,170,194,214],"triglycerides":[13,102,116,127,204],"is":[14,163,189,208,215,223],"influenced":[15],"by":[16,22,72,83,192,198,212,226],"major":[17],"plasma":[18,147,159,172,236],"apolipoproteins,":[19],"as":[20],"suggested":[21],"recent":[23],"experimental":[24],"evidence.":[25],"RESEARCH":[26],"DESIGN":[27],"AND":[28],"METHODSdCross-sectional":[29],"analysis":[30],"RISC":[33],"Study,":[34],"a":[35,186],"multicenter":[36],"European":[37],"clinical":[38],"investigation":[39],"in":[40,45,58,153,209],"1,017":[41],"healthy":[42],"volunteers":[43],"balanced":[44],"sex":[46],"(women":[47],"54%)":[48],"age":[50],"strata":[51],"(range":[52],"30\u201360":[53],"years).":[54],"Insulin":[55],"(M/I":[57],"mmol":[59],"z":[60,63,66],"min":[61],"21":[62,65,68],"kgFFM":[64],"nM":[67],")":[69],"was":[70],"measured":[71],"clamp":[74],"technique":[75],"apolipoproteins":[77],"(ApoB,":[78],"-C3,":[79],"-A1,":[80],"-E)":[82],"Multiplex":[84],"Technology.":[85],"RESULTSdThe":[86],"center-,":[87],"sex-,":[88],"age-adjusted":[90],"standardized":[91],"regression":[92],"coefficients":[93],"(STDb)":[94],"M/I":[96,144],"were":[97],"similar":[98],"for":[99,115],"(+19.9":[103],"6":[104,108,129],"1.9":[105],"vs.":[106],"220.0":[107],"2.0,":[109],"P":[110,131],",":[111,132],"0.0001).":[112],"Further":[113],"adjustment":[114],"(or":[117,122],"HDL),":[118],"BMI,":[119],"adiponectin":[121,195],"nonesterified":[123],"fatty":[124],"acid)":[125],"attenuatedthestrengthoftheassociationofM/IwithbothHDL(STDb+6.462.3,P,0.01)and":[126],"(29.5":[128],"2.1,":[130],"0.001).":[133],"Neither":[134],"ApoA1":[135],"nor":[136],"ApoE":[137,218],"ApoB":[139],"showed":[140],"any":[141],"independent":[145],"from":[146,231],"triglycerides.":[151],"ApoC3,":[152,227],"contrast,inbothmenandwomen,waspositivelyassociatedwithM/Iindependentlyofplasmalipids.":[154],"A":[155],"relative":[156],"enrichment":[157],"lipids":[160],"ApoC3":[162],"associated":[164],"lower":[166,171],"body":[167],"fat":[168],"percentage":[169],"alanine":[173],"amino":[174],"transferase.":[175],"CONCLUSIONSdOur":[176],"results":[177],"suggest":[178],"that":[179,188],"modulates":[182],"through":[185],"mechanism":[187],"partially":[190],"mediated":[191,211],"BMI":[193,213],"but":[196,221],"not":[197],"ApoA1.":[199],"Similarly,":[200],"influence":[202],"on":[205],"part":[210],"unrelated":[216],"to":[217,229],"or":[219],"ApoB,":[220],"it":[222],"significantly":[224],"modulated":[225],"whichappears":[228],"protect":[230],"negative":[233],"effect":[234],"lipids.":[237]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}