{"id":"https://openalex.org/W2182532397","doi":null,"title":"Anti-inflammatory action of Ginkgo Biloba leaf polysaccharide viaTLR4/NF-?b signaling suppression.","display_name":"Anti-inflammatory action of Ginkgo Biloba leaf polysaccharide viaTLR4/NF-?b signaling suppression.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182532397","mag":"2182532397"},"language":"en","primary_location":{"id":"mag:2182532397","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/antiinflammatory-action-of-ginkgo-biloba-leaf-polysaccharide-viatlr4nfb-signaling-suppression.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083923445","display_name":"Xiaoli Zhou","orcid":"https://orcid.org/0000-0002-3096-3911","observed_orcids":["https://orcid.org/0000-0002-3096-3911","https://orcid.org/0009-0007-5169-8540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoli Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3096-3911","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020652950","display_name":"Ming Hui Yang","orcid":"https://orcid.org/0000-0002-7735-7804","observed_orcids":["https://orcid.org/0000-0002-7735-7804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7735-7804","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103577199","display_name":"Baigong Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baigong Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hai\u2010Tao He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai\u2010Tao He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chunmei Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunmei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379992","display_name":"Miaomiao Liu","orcid":"https://orcid.org/0000-0003-0930-3617","observed_orcids":["https://orcid.org/0000-0003-0930-3617","https://orcid.org/0000-0003-3934-9448","https://orcid.org/0009-0002-2518-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miaomiao Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0930-3617","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633171","display_name":"Lijiao Zhang","orcid":"https://orcid.org/0000-0002-7318-1813","observed_orcids":["https://orcid.org/0000-0002-7318-1813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijiao Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7318-1813","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001017518","display_name":"Rui Fei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Fei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8002,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77424529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":"4","first_page":"0","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.890999972820282},{"id":"https://openalex.org/keywords/tlr4-nf-kappab-signaling-pathway","display_name":"TLR4/NF-\u03baB signaling","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8669999837875366},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9860000014305115},{"id":"https://openalex.org/keywords/herbal-polysaccharides","display_name":"herbal polysaccharides","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2778998842","wikidata":"https://www.wikidata.org/wiki/Q43284","display_name":"Ginkgo biloba","level":2,"score":0.9797137379646301},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.8291078805923462},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6522561311721802},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5814787745475769},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.5463862419128418},{"id":"https://openalex.org/C2779706397","wikidata":"https://www.wikidata.org/wiki/Q149461","display_name":"Ginkgo","level":2,"score":0.5317220687866211},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5260417461395264},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5099159479141235},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48787903785705566},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.483277827501297},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47638195753097534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4713149666786194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29925137758255005},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2818300724029541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2646925449371338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2595466077327728},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24783483147621155},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06859123706817627}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182532397","doi":null,"is_oa":false,"landing_page_url":"https://www.alliedacademies.org/articles/antiinflammatory-action-of-ginkgo-biloba-leaf-polysaccharide-viatlr4nfb-signaling-suppression.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W19051514","https://openalex.org/W1565706607","https://openalex.org/W1965350798","https://openalex.org/W1969891196","https://openalex.org/W1978180376","https://openalex.org/W1990630860","https://openalex.org/W2009062406","https://openalex.org/W2010195407","https://openalex.org/W2012884604","https://openalex.org/W2041287049","https://openalex.org/W2050677222","https://openalex.org/W2052500103","https://openalex.org/W2053963810","https://openalex.org/W2065210647","https://openalex.org/W2067384349","https://openalex.org/W2088182422","https://openalex.org/W2128517604","https://openalex.org/W2143841612"],"related_works":["https://openalex.org/W1869609406","https://openalex.org/W2120884280","https://openalex.org/W2897570691","https://openalex.org/W2075610879","https://openalex.org/W2057826218","https://openalex.org/W2063929519","https://openalex.org/W2911438676","https://openalex.org/W2990073535","https://openalex.org/W2023079466","https://openalex.org/W2116915537"],"abstract_inverted_index":{"Ginkgo":[0,19,42],"biloba":[1,20,43],"is":[2],"a":[3,83],"valuable":[4],"herb":[5],"that":[6,66],"has":[7],"been":[8],"used":[9],"as":[10,28,107],"traditional":[11],"medicine":[12],"for":[13],"thousands":[14],"of":[15,18,38,77,103,130],"years.":[16],"Extract":[17],"leaves":[21],"possesses":[22],"several":[23],"clinical":[24],"beneficial":[25],"effects":[26],"such":[27,106],"antiinflammatory":[29],"property.":[30],"In":[31,115],"this":[32],"study,":[33],"we":[34],"investigated":[35],"the":[36,59,71,89,101],"effect":[37,121],"purified":[39],"polysaccharides":[40],"from":[41],"leaf":[44],"(P-PGBL)":[45],"on":[46],"inflammatory":[47,131],"reaction":[48],"induced":[49],"by":[50,113,122],"lipopolysaccharides":[51],"(LPS)":[52],"in":[53,82,95],"RAW264.7":[54,97],"mouse":[55],"macrophage":[56,98],"cells":[57],"and":[58,74,109],"potential":[60],"underlying":[61],"mechanisms.":[62],"The":[63],"results":[64],"showed":[65],"P-PGBL":[67,86,117],"treatment":[68,87],"significantly":[69],"inhibited":[70],"LPS-induced":[72],"protein":[73,93],"mRNA":[75],"expression":[76,94],"Toll-like":[78],"receptor":[79],"4":[80],"(TLR4)":[81],"dose-dependent":[84],"manner.":[85],"downregulated":[88],"nuclear":[90],"factor-\u03baB":[91],"(NF-\u03baB)p65":[92],"LPS-stimulated":[96],"cells.":[99],"Meanwhile,":[100],"levels":[102],"pro-inflammatory":[104],"cytokines,":[105],"IL-1\u03b2":[108],"IL-6":[110],"were":[111],"suppressed":[112],"P-PGBL.":[114],"conclusion,":[116],"exerts":[118],"an":[119],"anti-inflammatory":[120],"inhibiting":[123],"TLR4/NF-\u03baB":[124],"signaling":[125],"pathway,":[126],"thereby":[127],"lowering":[128],"production":[129],"cytokines.":[132]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}