{"id":"https://openalex.org/W2182503535","doi":null,"title":"Formulation and Evaluation of Bilayer Tablet of Amlodipine and Metoprolol in the Treatment of Hypertension","display_name":"Formulation and Evaluation of Bilayer Tablet of Amlodipine and Metoprolol in the Treatment of Hypertension","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2182503535","mag":"2182503535"},"language":"en","primary_location":{"id":"mag:2182503535","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/v28-1/21.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024729557","display_name":"A. Hariom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Hariom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084147932","display_name":"Prakash Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prakash Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109475484","display_name":"V. Lokeswara Babu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Lokeswara Babu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086547097","display_name":"Mohd Abdul Hadi","orcid":"https://orcid.org/0000-0001-5245-4213","observed_orcids":["https://orcid.org/0000-0001-5245-4213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohd Abdul Hadi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5245-4213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070097174","display_name":"A Srinivasa Rao","orcid":"https://orcid.org/0000-0002-7230-0286","observed_orcids":["https://orcid.org/0000-0002-7230-0286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Srinivasa Rao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7230-0286","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"B. R. Nagar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. R. Nagar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6532999873161316,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilayer-tablets","display_name":"bilayer tablets","score":0.9300000071525574},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immediate-release","display_name":"immediate release","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9950000047683716},{"id":"https://openalex.org/keywords/crospovidone","display_name":"crospovidone","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.6499999761581421},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.6759999990463257},{"id":"https://openalex.org/keywords/release-kinetics","display_name":"release kinetics","score":0.734000027179718},{"id":"https://openalex.org/keywords/stability-studies","display_name":"stability studies","score":0.5170000195503235},{"id":"https://openalex.org/keywords/compression-parameters","display_name":"compression parameters","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.8252458572387695},{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.7753702402114868},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7669892311096191},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.7144011855125427},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5551643967628479},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.515738308429718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4923504590988159},{"id":"https://openalex.org/C138651985","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutics","level":2,"score":0.46918725967407227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44786375761032104},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4172735810279846},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3287951946258545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26247838139533997},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14641684293746948},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12309134006500244},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.11404824256896973},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08787038922309875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0811397135257721},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07384654879570007},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06235259771347046}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182503535","doi":null,"is_oa":false,"landing_page_url":"http://globalresearchonline.net/journalcontents/v28-1/21.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1603994966","https://openalex.org/W2064822810","https://openalex.org/W2599892574","https://openalex.org/W2894342648"],"related_works":["https://openalex.org/W2282807898","https://openalex.org/W2599892574","https://openalex.org/W6949339081","https://openalex.org/W7162762903","https://openalex.org/W7163509131","https://openalex.org/W2810738646","https://openalex.org/W7222063900","https://openalex.org/W4410702428","https://openalex.org/W7219208134","https://openalex.org/W2966494497"],"abstract_inverted_index":{"The":[0,21,40,69,84,104,171],"current":[1],"work":[2],"focuses":[3],"on":[4],"the":[5,17,108,118,130,139,151],"development":[6],"and":[7,25,35,50,54,63,73,88,90,99,115,120,142,153,184,205,214],"evaluation":[8],"of":[9,12,19,23,48,57,71,110,132,149,190,203],"bilayer":[10,168,200],"tablet":[11,169,201],"Amlodipine":[13,24,204],"&":[14],"Metoprolol":[15,26,206],"in":[16,127,181],"treatment":[18],"hypertension.":[20],"release":[22,37,65,96,155,216],"was":[27,42,79,136],"controlled":[28],"by":[29,210],"formulating":[30],"it":[31,135],"into":[32],"a":[33,166,188,198],"immediate":[34,62,152,213],"sustained":[36,64,154,215],"layer":[38,156],"respectively.":[39,158],"formulae":[41],"developed":[43,209],"using":[44,81],"various":[45,51],"individual":[46,52],"concentrations":[47,53],"crospovidone":[49],"viscosity":[55],"grades":[56],"HPMC":[58],"polymers":[59,72],"for":[60,173,187],"both":[61,161,212],"layers":[66],"respectively":[67],".":[68],"compatibility":[70],"excipients":[74],"along":[75],"with":[76],"pure":[77],"drugs":[78],"evaluated":[80],"FTIR":[82,105],"studies.":[83],"tablets":[85],"were":[86,102,123,144,162,207],"prepared":[87],"Pre-":[89],"Post-compression":[91],"parameters,":[92],"In-vitro":[93],"dissolution":[94,133,185],"testing,":[95],"rate":[97],"kinetics":[98],"stability":[100,174],"studies":[101,175],"evaluated.":[103],"spectra\u2019s":[106],"confirms":[107],"absence":[109],"chemical":[111],"interaction":[112],"between":[113],"drug":[114,182],"polymers.":[116],"All":[117],"Pre":[119],"post-compression":[121],"parameters":[122],"found":[124,137,145],"to":[125,146,164],"be":[126,147],"limits.":[128],"From":[129],"results":[131],"testing":[134],"that":[138,177],"batches":[140,157],"IRL-4":[141],"SRL-12":[143],"best":[148],"all":[150],"Thus":[159],"they":[160],"compressed":[163],"get":[165],"novel":[167,199],"formulation.":[170],"data":[172],"revealed":[176],"no":[178],"considerable":[179],"differences":[180],"content":[183],"rates":[186],"period":[189],"6":[191],"months":[192],"as":[193],"per":[194],"ICH":[195],"guidelines.":[196],"Thus,":[197],"formulation":[202],"successfully":[208],"combining":[211],"layers.":[217]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
