{"id":"https://openalex.org/W2182492236","doi":null,"title":"THE INFLUENCE OF A NEW RUTIN DERIVATIVE ON HOMOCYSTEINE, CHOLESTEROL AND TOTAL ANTIOXIDATIVE STATUS IN EXPERIMENTAL DIABETES IN RAT","display_name":"THE INFLUENCE OF A NEW RUTIN DERIVATIVE ON HOMOCYSTEINE, CHOLESTEROL AND TOTAL ANTIOXIDATIVE STATUS IN EXPERIMENTAL DIABETES IN RAT","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2182492236","mag":"2182492236"},"language":"en","primary_location":{"id":"mag:2182492236","doi":null,"is_oa":false,"landing_page_url":"http://www.revistafarmacia.ro/201306/art-13-albu%201167-1177.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Elena Albu","orcid":"https://orcid.org/0000-0003-2602-0918","observed_orcids":["https://orcid.org/0000-0003-2602-0918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Albu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2602-0918","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104098800","display_name":"Cristiana Filip","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristiana Filip","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009916917","display_name":"Nina Zamosteanu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nina Zamosteanu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Grigore T. Popa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grigore T. Popa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l3","display_name":"L3","score":0.6019999980926514},{"id":"https://openalex.org/keywords/pyrimidines","display_name":"pyrimidines","score":0.6119999885559082},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/total-antioxidant-status","display_name":"total antioxidant status","score":0.9240000247955322},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6290000081062317},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.44999998807907104},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5540000200271606},{"id":"https://openalex.org/keywords/glucose-levels","display_name":"glucose concentration","score":0.593999981880188},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.578000009059906},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.800000011920929},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.5180000066757202},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7605002522468567},{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.7049295902252197},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6518554091453552},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.6150438189506531},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.569962739944458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4842507541179657},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48072007298469543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4719718396663666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4528535008430481},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4235476851463318},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37849926948547363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29162922501564026}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182492236","doi":null,"is_oa":false,"landing_page_url":"http://www.revistafarmacia.ro/201306/art-13-albu%201167-1177.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1577677666","https://openalex.org/W1593484344","https://openalex.org/W1911748160","https://openalex.org/W1948854550","https://openalex.org/W1971171314","https://openalex.org/W1976616659","https://openalex.org/W1980673430","https://openalex.org/W1988797498","https://openalex.org/W1996355712","https://openalex.org/W1997517682","https://openalex.org/W1998029089","https://openalex.org/W2012549875","https://openalex.org/W2018557415","https://openalex.org/W2020267609","https://openalex.org/W2028385130","https://openalex.org/W2028681847","https://openalex.org/W2029385436","https://openalex.org/W2037480727","https://openalex.org/W2038246124","https://openalex.org/W2072092143","https://openalex.org/W2082548679","https://openalex.org/W2088012387","https://openalex.org/W2088733086","https://openalex.org/W2118733774","https://openalex.org/W2124378690","https://openalex.org/W2125321964","https://openalex.org/W2132878122","https://openalex.org/W2139720861","https://openalex.org/W2144684988","https://openalex.org/W2169704952","https://openalex.org/W2183464170","https://openalex.org/W2341839661"],"related_works":["https://openalex.org/W2082548679","https://openalex.org/W2990108593","https://openalex.org/W2147125934","https://openalex.org/W2945319519","https://openalex.org/W7203443848","https://openalex.org/W2768486683","https://openalex.org/W6960093548","https://openalex.org/W2077909901","https://openalex.org/W3048263540","https://openalex.org/W3187756072"],"abstract_inverted_index":{"Diabetes":[0,127],"is":[1,31,62],"a":[2,82,101,131,311],"widely":[3],"spread":[4],"metabolic":[5],"disease":[6,34],"that":[7,177],"involves":[8],"disturbances":[9],"in":[10,20,29,60,94,97,201,228,288,298],"the":[11,25,32,46,54,79,89,106,117,145,151,178],"glucose,":[12,154],"lipid":[13,120],"and":[14,35,45,67,123,157,163,170,187,190],"mineral":[15],"levels,":[16,192],"as":[17,19,42],"well":[18],"redox":[21],"reactions.":[22],"One":[23],"of":[24,81,119,134,138,142,153,167],"major":[26,73,198,227],"risk":[27,74,92,199],"factors":[28,52,93,200],"diabetes":[30,61,96],"cardiovascular":[33],"its":[36],"complications.":[37],"Several":[38],"biochemical":[39],"parameters":[40],"such":[41],"hypercholesterolemia,":[43],"hyperhomocysteinemia":[44],"reactive":[47,248],"species":[48],"are":[49],"considered":[50],"aggravating":[51],"for":[53,114],"diabetes.":[55,202],"The":[56,76,140,173],"first":[57],"therapeutic":[58],"option":[59],"to":[63,70,105],"lower":[64],"glucose":[65],"levels":[66,152],"most":[68],"often":[69],"decrease":[71,122],"these":[72],"factors.":[75],"study":[77],"investigated":[78],"influence":[80,141],"new":[83,179],"rutin":[84,107,180],"derivative":[85],"(coded":[86],"L3)":[87,282],"on":[88],"previously":[90],"mentioned":[91],"experimentally-induced":[95],"rats.":[98],"L3":[99,143,171,295],"contains":[100],"pyrimidine":[102],"group":[103],"attached":[104],"molecule.":[108],"We":[109],"envisaged":[110],"two":[111],"pharmacological":[112],"activities":[113],"this":[115],"compound:":[116],"effect":[118],"level":[121],"an":[124],"anti-oxidative":[125,185],"activity.":[126],"was":[128,148],"induced":[129],"by":[130],"single":[132],"dose":[133],"110":[135],"mg/kg":[136],"bw":[137],"alloxan.":[139],"over":[144],"diabetic":[146],"status":[147,160],"determined":[149],"measuring":[150],"cholesterol,":[155],"homocysteine":[156,191],"total":[158],"antioxidant":[159],"(TAS)":[161],"initially":[162],"after":[164],"one":[165],"month":[166],"previous":[168],"alloxan":[169],"administration.":[172],"obtained":[174],"data":[175],"suggest":[176],"derivative,":[181],"coded":[182],"L3,":[183],"presents":[184],"properties":[186],"decreases":[188],"cholesterol":[189],"thus":[193],"conferring":[194],"protection":[195],"against":[196],"certain":[197],"Rezumat":[203],"Diabetul":[204,310],"zaharat":[205],"este":[206],"o":[207],"boala":[208,229],"metabolica":[209],"larg":[210],"rasp\u00e2ndita,":[211],"care":[212],"implica":[213],"modificari":[214],"ale":[215],"nivelelor":[216,262],"de":[217,225,249,263,271,279,286],"glucoza,":[218],"lipide":[219],"si":[220,235,246,265,308],"minerale.":[221],"Unul":[222],"din":[223],"factorii":[224],"risc":[226],"diabetica":[230],"il":[231],"constituie":[232],"bolile":[233],"cardiovasculare":[234],"complica\u0163iile":[236],"lor.":[237],"Mai":[238],"mul\u0163i":[239],"parametri":[240],"biochimici,":[241],"cum":[242],"sunt":[243,251,260],"hipercolesterolemia,":[244],"hiperhomocisteinemia":[245],"speciile":[247],"oxigen":[250],"considera\u0163i":[252],"factori":[253,270,285],"agravan\u0163i":[254],"ai":[255],"diabetului.":[256],"Primele":[257],"op\u0163iuni":[258],"terapeutice":[259],"scaderea":[261],"glucoza":[264],"mai":[266],"ales":[267],"diminuarea":[268],"acestor":[269,284],"risc.":[272],"Studiul":[273],"investigheaza":[274],"influen\u0163a":[275],"unui":[276],"nou":[277],"derivat":[278],"rutozid":[280],"(notat":[281],"asupra":[283],"risc,":[287],"diabetul":[289],"experimental":[290],"la":[291],"sobolani.":[292],"Pentru":[293],"derivatul":[294],"(care":[296],"con\u0163ine":[297],"structura":[299],"un":[300],"rest":[301],"pirimidinic)":[302],"s-au":[303],"urmarit":[304],"doua":[305],"efecte:":[306],"hipolipemiant":[307],"antioxidant.":[309],"fost":[312],"indus":[313]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}