{"id":"https://openalex.org/W2182464017","doi":null,"title":"Modulation by cationic amphiphilic drugs of serine base-exchange, phosholipase d and intracellular calcium homeostasis in glioma C6 cells.","display_name":"Modulation by cationic amphiphilic drugs of serine base-exchange, phosholipase d and intracellular calcium homeostasis in glioma C6 cells.","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2182464017","mag":"2182464017","pmid":"https://pubmed.ncbi.nlm.nih.gov/12593535"},"language":"en","primary_location":{"id":"pmid:12593535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12593535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031553636","display_name":"Marta Bobeszko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Bobeszko","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, PL 02-093 Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, PL 02-093 Warszawa, Poland","institution_ids":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061147727","display_name":"Rafa\u0142 Czajkowski","orcid":"https://orcid.org/0000-0002-9793-5421","observed_orcids":["https://orcid.org/0000-0002-9793-5421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafa\u0142 Czajkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Magdalena W\u00f3jcik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena W\u00f3jcik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080532109","display_name":"Pawe\u0142 Saba\u0142a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawe\u0142 Saba\u0142a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023647157","display_name":"Lingsheng Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingsheng Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073568711","display_name":"Irena Nalepa","orcid":"https://orcid.org/0000-0002-7821-0206","observed_orcids":["https://orcid.org/0000-0002-7821-0206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irena Nalepa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006942319","display_name":"Jolanta Bara\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanta Bara\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3772,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55543653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"54","issue":"5","first_page":"483","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cationic-amphiphilic-drugs","display_name":"cationic amphiphilic drugs","score":0.9620000123977661},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":1.0},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7160000205039978},{"id":"https://openalex.org/keywords/phosphatidylserine-synthesis","display_name":"phosphatidylserine synthesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.9890000224113464},{"id":"https://openalex.org/keywords/phosphatidylethanol","display_name":"phosphatidylethanol","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9300000071525574},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.6970000267028809},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mianserin","display_name":"mianserin","score":0.671999990940094},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6573562622070312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5405074954032898},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.481513112783432},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43644142150878906},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.43170279264450073},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.42564183473587036},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.42039230465888977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.413338840007782},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26709648966789246},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.18600910902023315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17246893048286438},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010718","descriptor_name":"Phosphatidylserines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12593535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12593535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.414.3839","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.414.3839","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.if-pan.krakow.pl/pjp/pdf/2002/5_483.pdf","raw_type":"text"},{"id":"mag:2182464017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12593535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1563381331","https://openalex.org/W1695689747","https://openalex.org/W1874327812","https://openalex.org/W1929121009","https://openalex.org/W1966254317","https://openalex.org/W1968885857","https://openalex.org/W1971747715","https://openalex.org/W1999174672","https://openalex.org/W2002441736","https://openalex.org/W2004368783","https://openalex.org/W2020564118","https://openalex.org/W2026627756","https://openalex.org/W2031410496","https://openalex.org/W2038072203","https://openalex.org/W2039644412","https://openalex.org/W2047436637","https://openalex.org/W2049444568","https://openalex.org/W2049710896","https://openalex.org/W2051194050","https://openalex.org/W2054505151","https://openalex.org/W2061315052","https://openalex.org/W2066553142","https://openalex.org/W2069006956","https://openalex.org/W2081410798","https://openalex.org/W2086619790","https://openalex.org/W2089048396","https://openalex.org/W2094618454","https://openalex.org/W2118872033","https://openalex.org/W2130318893","https://openalex.org/W2152311269","https://openalex.org/W2157312088","https://openalex.org/W2160654988","https://openalex.org/W2215056445","https://openalex.org/W2402117043","https://openalex.org/W2413649989","https://openalex.org/W2469293164"],"related_works":["https://openalex.org/W7097914475","https://openalex.org/W2922140328","https://openalex.org/W2086118696","https://openalex.org/W2469293164","https://openalex.org/W2020564118","https://openalex.org/W1984282648","https://openalex.org/W1984227571","https://openalex.org/W1999174672","https://openalex.org/W2049710896","https://openalex.org/W2414955904"],"abstract_inverted_index":{"We":[0,125],"aimed":[1],"to":[2,10],"assess":[3],"the":[4,132,145,156,179,238],"effect":[5,35,42,115],"of":[6,52,62,66,101,123,131,176,227,237,241],"three":[7],"drugs":[8,95],"belonging":[9],"amphiphilic":[11,71,135,192],"cations,":[12],"imipramine,":[13,214],"amitriptyline":[14,215],"and":[15,20,30,49,103,149,165,185,199,203,206,216,222],"propranolol,":[16,46],"on":[17,36,230],"lipid":[18,220],"synthesis":[19,100,198,221],"intracellular":[21,146,157,223],"calcium":[22,224],"homeostasis":[23],"in":[24,144],"glioma":[25],"C6":[26],"cells.":[27],"Antidepressants,":[28],"imipramine":[29],"amitriptyline,":[31],"had":[32],"a":[33,59,141],"stimulatory":[34],"[14C]serine":[37],"incorporation":[38],"into":[39],"phosphatidylserine.":[40],"Similar":[41],"was":[43],"induced":[44],"by":[45,57,70,160,183,235],"antidysrhythmic":[47],"drug":[48],"an":[50,173],"antagonist":[51],"beta-adrenergic":[53],"receptor,":[54],"but":[55],"not":[56,151,190,195],"isoproterenol,":[58],"selective":[60],"agonist":[61],"this":[63,169],"receptor.":[64],"Stimulation":[65],"serine":[67],"base-exchange":[68],"activity":[69,202],"cations":[72,136],"occured":[73],"at":[74,118],"concentration":[75,91,122,148],"as":[76,78],"low":[77,119],"5-25":[79],"microM":[80],"that":[81,129,213],"may":[82,218],"be":[83],"reached":[84],"during":[85],"clinical":[86],"treatment.":[87],"At":[88],"much":[89],"higher":[90],"(250":[92],"microM),":[93],"those":[94],"also":[96,127],"stimulated":[97],"phospholipase":[98,110,200],"D-mediated":[99],"[14C]phosphatidylethanol":[102],"blocked":[104],"phorbol":[105],"ester-induced,":[106],"protein":[107],"kinase":[108],"C-dependent":[109],"D":[111,201],"activity.":[112],"The":[113],"latter":[114],"already":[116],"occurred":[117],"(25":[120],"microM)":[121],"drugs.":[124],"have":[126],"shown":[128],"treatment":[130,170],"cells":[133],"with":[134],"(1":[137],"mM)":[138],"produced":[139,204],"only":[140],"weak":[142],"increase":[143],"Ca2+":[147,153,177,208],"did":[150,194],"affect":[152,196],"release":[154],"from":[155,178],"stores":[158],"evoked":[159],"nucleotide":[161],"receptor":[162],"agonists,":[163],"ATP":[164],"ADP.":[166],"In":[167],"contrast,":[168],"strongly":[171],"diminished":[172],"unspecific":[174],"leak":[175],"endoplasmic":[180],"reticulum":[181],"caused":[182],"thapsigargin":[184],"ionomycin.":[186],"Mianserin,":[187],"which":[188],"is":[189],"cationic":[191],"drug,":[193],"phosphatidylserine":[197],"heterogenous":[205],"chaotic":[207],"responses.":[209],"Our":[210],"results":[211],"suggest":[212],"propranolol":[217],"modulate":[219],"signaling":[225],"independently":[226],"their":[228],"action":[229],"membrane":[231],"receptors,":[232],"most":[233],"probably":[234],"modification":[236],"physicochemical":[239],"properties":[240],"cell":[242],"membranes.":[243]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}