{"id":"https://openalex.org/W2182463445","doi":null,"title":"REVIEW ON NATURAL MEDICINAL SOURCE FOR CANCER TREATMENT","display_name":"REVIEW ON NATURAL MEDICINAL SOURCE FOR CANCER TREATMENT","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2182463445","mag":"2182463445"},"language":"en","primary_location":{"id":"mag:2182463445","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20153048569","pdf_url":null,"source":{"id":"https://openalex.org/S2764431408","display_name":"World Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"2278-4357","issn":["2278-4357"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072644252","display_name":"K. Arjunan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Arjunan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010278924","display_name":"B. Bharadhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Bharadhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028221056","display_name":"T. U. Poorani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. U. Poorani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090410119","display_name":"Vinutha Shankar","orcid":"https://orcid.org/0000-0002-5601-5346","observed_orcids":["https://orcid.org/0000-0002-5601-5346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinutha Shankar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5601-5346","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003304018","display_name":"A. Nagarjan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Nagarjan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079210976","display_name":"Meena Ramanathan","orcid":"https://orcid.org/0000-0002-7253-6504","observed_orcids":["https://orcid.org/0000-0002-7253-6504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meena Ramanathan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7253-6504","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3772,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64605725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":"1","first_page":"530","last_page":"549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.3118000030517578,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.3118000030517578,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8579999804496765},{"id":"https://openalex.org/keywords/plant-derived-anticancer-agents","display_name":"plant-derived anticancer agents","score":0.6340000033378601},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.7879999876022339},{"id":"https://openalex.org/keywords/marine-sponges","display_name":"marine sponges","score":0.8090000152587891},{"id":"https://openalex.org/keywords/marine-corals","display_name":"marine corals","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cytotoxic-compounds","display_name":"cytotoxic compounds","score":0.8220000267028809},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.7900000214576721},{"id":"https://openalex.org/keywords/vinca-alkaloids","display_name":"vinca alkaloids","score":0.6190000176429749},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/lead-compounds","display_name":"lead compounds","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.7070658206939697},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.6306620240211487},{"id":"https://openalex.org/C2781209748","wikidata":"https://www.wikidata.org/wiki/Q419953","display_name":"Topotecan","level":3,"score":0.6197286248207092},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.5214906930923462},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.5109485983848572},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.508155107498169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5072331428527832},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.45952779054641724},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.4558928310871124},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.441893607378006},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.42604148387908936},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3987639844417572},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3526015877723694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29351601004600525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19344496726989746},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.16362065076828003},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11248373985290527},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182463445","doi":null,"is_oa":false,"landing_page_url":"https://www.cabdirect.org/cabdirect/abstract/20153048569","pdf_url":null,"source":{"id":"https://openalex.org/S2764431408","display_name":"World Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"2278-4357","issn":["2278-4357"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W43994205","https://openalex.org/W76282750","https://openalex.org/W99906670","https://openalex.org/W154762673","https://openalex.org/W170504668","https://openalex.org/W205054588","https://openalex.org/W428023115","https://openalex.org/W1508395055","https://openalex.org/W1526338155","https://openalex.org/W1536161802","https://openalex.org/W1853736668","https://openalex.org/W1969862175","https://openalex.org/W1972075278","https://openalex.org/W1972945052","https://openalex.org/W1974495287","https://openalex.org/W1975020062","https://openalex.org/W1975759924","https://openalex.org/W1976083777","https://openalex.org/W1976712192","https://openalex.org/W1977581095","https://openalex.org/W1979400471","https://openalex.org/W1980133374","https://openalex.org/W1986330444","https://openalex.org/W1987187354","https://openalex.org/W1990418482","https://openalex.org/W1990632172","https://openalex.org/W1992556503","https://openalex.org/W1993417477","https://openalex.org/W1993850865","https://openalex.org/W1997614802","https://openalex.org/W1998891491","https://openalex.org/W2000949003","https://openalex.org/W2002801265","https://openalex.org/W2004085095","https://openalex.org/W2004383868","https://openalex.org/W2005027345","https://openalex.org/W2008950434","https://openalex.org/W2009159360","https://openalex.org/W2012815610","https://openalex.org/W2014023055","https://openalex.org/W2018252342","https://openalex.org/W2018968418","https://openalex.org/W2026497156","https://openalex.org/W2028784280","https://openalex.org/W2034112604","https://openalex.org/W2034726943","https://openalex.org/W2037268169","https://openalex.org/W2037293444","https://openalex.org/W2038585955","https://openalex.org/W2043294691","https://openalex.org/W2047314639","https://openalex.org/W2047548676","https://openalex.org/W2048629302","https://openalex.org/W2056109319","https://openalex.org/W2056244275","https://openalex.org/W2056866948","https://openalex.org/W2057875972","https://openalex.org/W2061078070","https://openalex.org/W2062559845","https://openalex.org/W2064745628","https://openalex.org/W2065439544","https://openalex.org/W2066504626","https://openalex.org/W2066761588","https://openalex.org/W2066830526","https://openalex.org/W2068925899","https://openalex.org/W2069077740","https://openalex.org/W2069083487","https://openalex.org/W2071839604","https://openalex.org/W2073251792","https://openalex.org/W2076429988","https://openalex.org/W2077890657","https://openalex.org/W2078886992","https://openalex.org/W2085914535","https://openalex.org/W2088347184","https://openalex.org/W2088601048","https://openalex.org/W2093391931","https://openalex.org/W2093438867","https://openalex.org/W2095488587","https://openalex.org/W2106881891","https://openalex.org/W2109335148","https://openalex.org/W2109882696","https://openalex.org/W2110689123","https://openalex.org/W2118050341","https://openalex.org/W2125140983","https://openalex.org/W2134849708","https://openalex.org/W2141110099","https://openalex.org/W2141474275","https://openalex.org/W2151089147","https://openalex.org/W2151151062","https://openalex.org/W2151296879","https://openalex.org/W2156367506","https://openalex.org/W2161497461","https://openalex.org/W2165529124","https://openalex.org/W2171810073","https://openalex.org/W2197560413","https://openalex.org/W2199297812","https://openalex.org/W2204157565","https://openalex.org/W2213382166","https://openalex.org/W2288583735","https://openalex.org/W2313542043","https://openalex.org/W2320521352","https://openalex.org/W2329219940","https://openalex.org/W2340832472","https://openalex.org/W2356535310","https://openalex.org/W2482424454","https://openalex.org/W2485407618","https://openalex.org/W3010829152"],"related_works":["https://openalex.org/W1999567188","https://openalex.org/W1661993026","https://openalex.org/W4405610608","https://openalex.org/W2417167336","https://openalex.org/W1917769679","https://openalex.org/W2745197172","https://openalex.org/W4304113572","https://openalex.org/W4308562616","https://openalex.org/W4394833464","https://openalex.org/W2980740996"],"abstract_inverted_index":{"Natural":[0],"products":[1,153],"have":[2,46],"been":[3,47],"regarded":[4],"as":[5,89],"important":[6],"sources":[7],"that":[8],"could":[9],"produce":[10],"potential":[11],"chemotherapeutic":[12],"agents.":[13],"Over":[14],"50%":[15,78],"of":[16,58,64,79,103,167],"anticancer":[17,104,143,168],"drugs":[18],"approved":[19],"by":[20],"United":[21],"States":[22],"Food":[23],"and":[24,53,91,114,120,123,127,138],"Drug":[25],"Administration":[26],"since":[27],"1960":[28],"were":[29,83],"originated":[30],"from":[31,36,49,55,85,136,151],"the":[32,56,101],"natural":[33,65,152],"resources,":[34],"especially":[35],"terrestrial":[37],"plants.":[38],"Based":[39],"on":[40],"cytotoxicity":[41],"bioassay,":[42],"over":[43],"400":[44],"compounds":[45,82],"isolated":[48,84],"plants,":[50],"marine":[51,72,86,116],"organisms":[52,87,117],"microorganisms":[54],"period":[57],"1996":[59],"to":[60,71,159],"2000.":[61],"Recently,":[62],"interest":[63],"product":[66],"research":[67],"has":[68],"slowly":[69],"moved":[70],"organisms.":[73],"As":[74],"a":[75,156],"result,":[76],"almost":[77],"reported":[80],"cytotoxic":[81],"such":[88],"sponges":[90],"corals.":[92],"The":[93],"plant":[94],"based":[95],"drug":[96],"discovery":[97],"resulted":[98],"mainly":[99],"in":[100,142],"development":[102],"agents":[105,134],"including":[106],"plants":[107],"(vincristine,":[108],"vinblastine,":[109],"etoposide,":[110],"paclitaxel,":[111],"camptothecin,":[112],"topotecan":[113],"irinotecan),":[115],"(citarabine,":[118],"aplidine":[119],"dolastatin":[121],"10)":[122],"micro-organisms":[124],"(dactinomycin,":[125],"bleomycin":[126],"doxorubicin).":[128],"Beside":[129],"this":[130,146],"there":[131],"is":[132],"numerous":[133],"identified":[135],"fruits":[137],"vegetables":[139],"can":[140],"used":[141],"therapy.":[144],"In":[145],"review":[147],"active":[148],"principle":[149],"derived":[150],"are":[154],"offering":[155],"great":[157],"opportunity":[158],"evaluate":[160],"not":[161],"only":[162],"totally":[163],"new":[164],"chemical":[165],"classes":[166],"agents,":[169],"but":[170],"also":[171],"novel":[172],"lead":[173]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}