{"id":"https://openalex.org/W2182316892","doi":null,"title":"Toward improving the diagnosis of Alzheimer's Disease","display_name":"Toward improving the diagnosis of Alzheimer's Disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2182316892","mag":"2182316892"},"language":"en","primary_location":{"id":"mag:2182316892","doi":null,"is_oa":false,"landing_page_url":"http://incenter.medical.philips.com/doclib/enc/fetch/2000/4504/577242/577256/588821/5050628/5313460/6391861/[10]_MM_54-1_Sadowski.pdf%3fnodeid%3d6392305%26vernum%3d1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080321307","display_name":"Martin J. Sadowski","orcid":"https://orcid.org/0000-0002-3830-1779","observed_orcids":["https://orcid.org/0000-0002-3830-1779"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martin Sadowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3830-1779","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080321307"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27381556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/alzheimer-s-disease-diagnosis","display_name":"Alzheimer's disease diagnosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9760000109672546},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7149999737739563},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neurofibrillary-degeneration","display_name":"neurofibrillary degeneration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7110000252723694},{"id":"https://openalex.org/keywords/normal-aging","display_name":"normal aging","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6477032899856567},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5642152428627014},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5530614256858826},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5406699776649475},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5287194848060608},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.506733238697052},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4920727610588074},{"id":"https://openalex.org/C2780749935","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive deficit","level":4,"score":0.47659581899642944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45443031191825867},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4469428062438965},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39406317472457886},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.3381992280483246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2968248128890991}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2182316892","doi":null,"is_oa":false,"landing_page_url":"http://incenter.medical.philips.com/doclib/enc/fetch/2000/4504/577242/577256/588821/5050628/5313460/6391861/[10]_MM_54-1_Sadowski.pdf%3fnodeid%3d6392305%26vernum%3d1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W57510132","https://openalex.org/W1476312560","https://openalex.org/W1809346617","https://openalex.org/W1881871550","https://openalex.org/W1967642097","https://openalex.org/W1982120496","https://openalex.org/W1987397445","https://openalex.org/W1996424261","https://openalex.org/W1998729594","https://openalex.org/W2003428745","https://openalex.org/W2004813308","https://openalex.org/W2006858320","https://openalex.org/W2009739635","https://openalex.org/W2021656729","https://openalex.org/W2029554137","https://openalex.org/W2032071029","https://openalex.org/W2032724652","https://openalex.org/W2040738466","https://openalex.org/W2041789591","https://openalex.org/W2045693977","https://openalex.org/W2052742260","https://openalex.org/W2053935454","https://openalex.org/W2065184319","https://openalex.org/W2065592408","https://openalex.org/W2076438985","https://openalex.org/W2081881251","https://openalex.org/W2085187999","https://openalex.org/W2086363884","https://openalex.org/W2086978209","https://openalex.org/W2092522921","https://openalex.org/W2096410114","https://openalex.org/W2101991516","https://openalex.org/W2114953476","https://openalex.org/W2133703021","https://openalex.org/W2134379460","https://openalex.org/W2152038045","https://openalex.org/W2153631628","https://openalex.org/W2156220037","https://openalex.org/W2159838014","https://openalex.org/W2161737267","https://openalex.org/W2163057869","https://openalex.org/W2166416515","https://openalex.org/W2167720733","https://openalex.org/W2188679450","https://openalex.org/W2295393683","https://openalex.org/W2479425174","https://openalex.org/W2522381947"],"related_works":["https://openalex.org/W1545800183","https://openalex.org/W2467994229","https://openalex.org/W2058226627","https://openalex.org/W2125367967","https://openalex.org/W2057771377","https://openalex.org/W2126149232","https://openalex.org/W2308713738","https://openalex.org/W4409078942","https://openalex.org/W1999971872","https://openalex.org/W3166430093"],"abstract_inverted_index":{"Figure":[0],"1.":[1],"Evolution":[2],"of":[3,58,72,78,87,98,107,126],"Alzheimer\u2019s":[4],"disease.":[5],"AD":[6,16,51,94],"is":[7,32,53,90],"characterized":[8],"by":[9,48],"progressive":[10,56],"cognitive":[11,23,30,43],"deficit":[12,44],"which":[13,68],"clearly":[14],"separates":[15],"patients":[17],"from":[18],"the":[19,66,76,88,92,101,127],"mild":[20],"decline":[21],"in":[22,65,100,104],"functions":[24],"associated":[25,54],"with":[26,55,123],"normal":[27],"aging.":[28],"Mild":[29],"impairment":[31],"a":[33,59,70,105],"clinical":[34,79,124],"state,":[35],"sometimes":[36],"prodromal":[37],"to":[38,75],"fully":[39],"symptomatic":[40],"AD,":[41],"where":[42],"can":[45],"be":[46],"delineated":[47],"psychometric":[49],"testing.":[50],"pathogenesis":[52],"accumulation":[57,97],"toxic":[60],"and":[61,117],"hydrophobic":[62],"As":[63,99],"peptide":[64],"brain,":[67],"starts":[69],"number":[71,106],"years":[73],"prior":[74],"onset":[77],"symptoms":[80,125],"(yellow":[81],"dotted":[82],"line).":[83,131],"This":[84],"preclinical":[85],"stage":[86],"disease":[89,128],"dubbed":[91],"\u201cbrain":[93],"stage\u201d.":[95],"Progressive":[96],"brain":[102],"results":[103],"secondary":[108],"pathological":[109],"processes":[110],"including":[111],"neurofibrillary":[112],"degeneration,":[113],"inflammation,":[114],"synaptic":[115],"loss,":[116],"neuronal":[118],"dropout,":[119],"whose":[120],"severity":[121],"correlates":[122],"(magenta":[129],"dashed":[130]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
