{"id":"https://openalex.org/W2182242671","doi":null,"title":"Molecular biology of pancreatic cancer--new aspects and targets.","display_name":"Molecular biology of pancreatic cancer--new aspects and targets.","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2182242671","mag":"2182242671","pmid":"https://pubmed.ncbi.nlm.nih.gov/18630509"},"language":"en","primary_location":{"id":"pmid:18630509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18630509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084866392","display_name":"G\u00fcnter Schneider","orcid":"https://orcid.org/0000-0003-1840-4508","observed_orcids":["https://orcid.org/0000-0003-1840-4508"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Schneider","raw_affiliation_strings":["Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. guenter.schneider@lrz.tum.de","Second Department of Internal Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. guenter.schneider@lrz.tum.de","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Second Department of Internal Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078401150","display_name":"Rainer Hamacher","orcid":"https://orcid.org/0000-0001-9655-1226","observed_orcids":["https://orcid.org/0000-0001-9655-1226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer Hamacher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103075832","display_name":"Stefan Eser","orcid":"https://orcid.org/0000-0002-2197-8281","observed_orcids":["https://orcid.org/0000-0002-2197-8281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Eser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109847207","display_name":"Helmut Frie\u00df","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helmut Friess","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473723","display_name":"Roland Michael Schmid","orcid":"https://orcid.org/0009-0000-8976-3300","observed_orcids":["https://orcid.org/0009-0000-8976-3300","https://orcid.org/0000-0002-6945-7581","https://orcid.org/0000-0002-5751-7313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland M Schmid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090240499","display_name":"Dieter Saur","orcid":"https://orcid.org/0000-0001-5874-0210","observed_orcids":["https://orcid.org/0000-0001-5874-0210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dieter Saur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9463,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.91553741,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"28","issue":"3A","first_page":"1541","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/apoptosis-evasion","display_name":"apoptosis evasion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/replicative-potential","display_name":"replicative potential","score":0.718999981880188},{"id":"https://openalex.org/keywords/tissue-invasion","display_name":"tissue invasion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8320000171661377},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6758241653442383},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6224167346954346},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5978635549545288},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5036234259605408},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4886830151081085},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.47844862937927246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47059857845306396},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4680107831954956},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4411674439907074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4344688057899475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4247395694255829},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4065752625465393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37135881185531616}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18630509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18630509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/736351","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/736351","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"mag:2182242671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18630509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W1565561072","https://openalex.org/W1568317880","https://openalex.org/W1604949025","https://openalex.org/W1859252938","https://openalex.org/W1963997955","https://openalex.org/W1964717481","https://openalex.org/W1965506737","https://openalex.org/W1966027561","https://openalex.org/W1966845502","https://openalex.org/W1967018540","https://openalex.org/W1967608817","https://openalex.org/W1970430170","https://openalex.org/W1976186224","https://openalex.org/W1978146894","https://openalex.org/W1978598058","https://openalex.org/W1979028962","https://openalex.org/W1979475139","https://openalex.org/W1979655901","https://openalex.org/W1983051282","https://openalex.org/W1984152709","https://openalex.org/W1984567221","https://openalex.org/W1985466280","https://openalex.org/W1986014209","https://openalex.org/W1988218110","https://openalex.org/W1991251040","https://openalex.org/W1994851993","https://openalex.org/W1996795813","https://openalex.org/W1998515109","https://openalex.org/W1999657064","https://openalex.org/W2000932071","https://openalex.org/W2001181170","https://openalex.org/W2002355858","https://openalex.org/W2003103533","https://openalex.org/W2007897263","https://openalex.org/W2009174142","https://openalex.org/W2011387381","https://openalex.org/W2011983325","https://openalex.org/W2015353751","https://openalex.org/W2018116689","https://openalex.org/W2018314777","https://openalex.org/W2020457650","https://openalex.org/W2020481638","https://openalex.org/W2025587382","https://openalex.org/W2028359994","https://openalex.org/W2029338379","https://openalex.org/W2031556612","https://openalex.org/W2032096654","https://openalex.org/W2040387759","https://openalex.org/W2041234310","https://openalex.org/W2042595053","https://openalex.org/W2046133342","https://openalex.org/W2049957499","https://openalex.org/W2050242039","https://openalex.org/W2051227958","https://openalex.org/W2051566245","https://openalex.org/W2055345604","https://openalex.org/W2056822884","https://openalex.org/W2056964258","https://openalex.org/W2063646414","https://openalex.org/W2066092045","https://openalex.org/W2066135299","https://openalex.org/W2066639629","https://openalex.org/W2067117191","https://openalex.org/W2068547732","https://openalex.org/W2074457423","https://openalex.org/W2075740127","https://openalex.org/W2076098855","https://openalex.org/W2076198969","https://openalex.org/W2077139169","https://openalex.org/W2078818685","https://openalex.org/W2079054128","https://openalex.org/W2079489832","https://openalex.org/W2081848947","https://openalex.org/W2082055110","https://openalex.org/W2083237227","https://openalex.org/W2085764502","https://openalex.org/W2090645842","https://openalex.org/W2092058648","https://openalex.org/W2092477182","https://openalex.org/W2096778246","https://openalex.org/W2098036848","https://openalex.org/W2099023480","https://openalex.org/W2100522747","https://openalex.org/W2100801124","https://openalex.org/W2100999453","https://openalex.org/W2104790339","https://openalex.org/W2105229473","https://openalex.org/W2109981415","https://openalex.org/W2120810131","https://openalex.org/W2122441872","https://openalex.org/W2123769936","https://openalex.org/W2125988618","https://openalex.org/W2126663928","https://openalex.org/W2126889260","https://openalex.org/W2128077493","https://openalex.org/W2134877501","https://openalex.org/W2135508788","https://openalex.org/W2137007717","https://openalex.org/W2139734459","https://openalex.org/W2140306297","https://openalex.org/W2140946995","https://openalex.org/W2141805477","https://openalex.org/W2143451209","https://openalex.org/W2143945054","https://openalex.org/W2144818167","https://openalex.org/W2146097802","https://openalex.org/W2149254325","https://openalex.org/W2154164444","https://openalex.org/W2156365755","https://openalex.org/W2159476762","https://openalex.org/W2161338384","https://openalex.org/W2163958696","https://openalex.org/W2166022410","https://openalex.org/W2166539171","https://openalex.org/W2166770565","https://openalex.org/W2167277834","https://openalex.org/W2168326607","https://openalex.org/W2170306299","https://openalex.org/W2181371279","https://openalex.org/W2304366241","https://openalex.org/W2319486658","https://openalex.org/W2413723137","https://openalex.org/W2509485398","https://openalex.org/W4255954285"],"related_works":["https://openalex.org/W2026266704","https://openalex.org/W4396769333","https://openalex.org/W2029189079","https://openalex.org/W2099023480","https://openalex.org/W3167641883","https://openalex.org/W2021051150","https://openalex.org/W2092554910","https://openalex.org/W4236269326","https://openalex.org/W3031455792","https://openalex.org/W20881767"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"is":[3,28],"a":[4,8],"dismal":[5],"disease":[6],"with":[7],"median":[9],"survival":[10,20],"of":[11,56,65,83],"less":[12,22],"than":[13,23],"6":[14],"months":[15],"and":[16,33,47,91],"an":[17],"overall":[18],"5-year":[19],"rate":[21],"1%.":[24],"This":[25],"bad":[26],"prognosis":[27],"due":[29],"to":[30,74,78],"early":[31],"lymphatic":[32],"hematogenic":[34],"dissemination.":[35],"Effective":[36],"therapies":[37],"for":[38],"locally":[39],"advanced":[40],"or":[41],"metastatic":[42],"tumors":[43],"are":[44,97],"very":[45],"limited":[46],"curatively":[48],"resected":[49],"patients":[50],"experience":[51],"relapse":[52],"in":[53],"over":[54],"80%":[55],"cases.":[57],"Together,":[58],"these":[59],"findings":[60],"reflect":[61],"the":[62,66],"aggressive":[63],"biology":[64],"disease.":[67],"Here,":[68],"we":[69],"describe":[70],"molecular":[71],"mechanisms":[72],"leading":[73],"unrestrained":[75],"proliferation,":[76],"insensitivity":[77],"growth":[79],"inhibitory":[80],"signals,":[81],"evasion":[82],"apoptosis,":[84],"limitless":[85],"replicative":[86],"potential,":[87],"tissue":[88],"invasion,":[89],"metastasis":[90],"sustained":[92],"angiogenesis.":[93],"Potential":[94],"therapeutic":[95],"targets":[96],"highlighted.":[98]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
